Results 61 to 70 of about 4,258 (187)

RiboMicrobe: An Integrated Translatome Atlas for Microorganism. [PDF]

Adv Sci (Weinh)
Abstract Ribosome profiling (Ribo‐seq) represents a significant advance in translatomics research. This technique enables the precise measurement of global and in vivo translation dynamics, the quantification of translation, and the identification of active translated small open reading frames (sORFs).
Zhou Y, Luo J, Lang X, Gan Y, Liu G, Cui Y, Li F, Zhu W, Chen B, Dong Y, Wu Y, Cao Y, Liu Q.   +12 more
europepmc   +4 more sources

Bridging the gap between genomic, phenotypic, and modeling data in picophytoplankton–virus interactions

Journal of Phycology, EarlyView.
Abstract We present a comprehensive synthesis of recent developments in methodological approaches to combine experimental and genomic studies of picophytoplankton–virus interactions. This synthesis will not only enhance our understanding of these relationships but also stimulate new hypotheses for the interpretation of metagenomic data and enrich ...
Luisa Listmann, Carina Peters, Anais Labecot, Raphaël Rousseau, Christie Baux, Maria Elisabetta Santelia, Eric Manirakiza, Nigel Grimsley, Sheree Yau, Sébastien Gourbiere, C‐Elisa Schaum, Gwenael Piganeau   +11 more
wiley   +1 more source

Translatome Regulation in Neuronal Injury and Axon Regrowth [PDF]

eneuro, 2018
Abstract Transcriptional events leading to outgrowth of neuronal axons have been intensively studied, but the role of translational regulation in this process is not well understood. Here, we use translatome analyses by ribosome pull-down and protein synthesis characterization by metabolic isotopic labeling to study nerve injury and ...
Meir Rozenbaum, Marek Rajman, Ida Rishal, Indrek Koppel, Sandip Koley, Katalin F. Medzihradszky, Juan A. Oses-Prieto, Riki Kawaguchi, Paul S. Amieux, Alma L. Burlingame, Giovanni Coppola, Mike Fainzilber   +11 more
openaire   +5 more sources

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

Nature Communications, 2022
Alzheimer’s disease is associated with changes in astrocytes. Here the authors investigated the astrocyte translatome associated with amyloid-ß and tau pathology.
Zoeb Jiwaji, Sachin S. Tiwari, Rolando X. Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A. Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M. Smith, Peta Greer, Matthew Ball, Peter C. Kind, Paul M. Matthews, Colin Smith, Owen Dando, Tara L. Spires-Jones, Jeffrey A. Johnson, Siddharthan Chandran, Giles E. Hardingham   +30 more
doaj   +1 more source

Peripheral regeneration of Aβ low‐threshold mechanoreceptors is limited despite activation of regenerative transcriptional pathways

The Journal of Physiology, EarlyView.
Abstract figure legend The regeneration of Aβ low‐threshold mechanoreceptors (Aβ‐LTMRs), sensory neurons responsible for discriminative touch, has not previously been explored. Here, we took advantage of the selective expression of Calb1 in Aβ‐LTMRs to generate two genetic mouse models for studying their regenerative response after nerve injury.
Sara Bolívar, Natàlia Martínez‐Mateu, David Ovelleiro, Esther Udina   +3 more
wiley   +1 more source

IGF2 mRNA binding protein 3 (IMP3) mediated regulation of transcriptome and translatome in glioma cells

, 2017
RNA binding proteins mediate global regulation at the level of transcriptome and translatome of a cell. We studied the global level expression changes regulated by IMP3 in transcriptome and translatome by performing microarray using total cellular RNA ...
Somasundaram, Kumaravel, Riyaz Ahmad Shah, Shruti Bhargava, Bhargava, Shruti, Shah, Riyaz Ahmad, Vikas Patil, Kumaravel Somasundaram, Patil, Vikas   +7 more
core   +1 more source

Translational Control under Stress: Reshaping the Translatome [PDF]

BioEssays, 2019
Adequate reprogramming of cellular metabolism in response to stresses or suboptimal growth conditions involves a myriad of coordinated changes that serve to promote cell survival. As protein synthesis is an energetically expensive process, its regulation under stress is of critical importance.
Vivek M, Advani, Pavel, Ivanov
openaire   +2 more sources

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, Volume 13, Issue 49, 3 September 2026.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source

Additional translatome evidence for the predicted functional AS events.

, 2012
The total numbers of reads supporting each of the alternatives are given for the translatome data as determined using MISO. “X” is used to denote that an AS event could not be confirmed in this analysis.
Aalt D. J. van Dijk (18076), Jacqueline Busscher-Lange (186442), Edouard I. Severing (186432), Roeland C. H. J. van Ham (116982), Giuseppa Morabito (186438), Richard G. H. Immink (186449)   +5 more
core   +1 more source

Distinct perturbation of the translatome by the antidiabetic drug metformin [PDF]

Proceedings of the National Academy of Sciences, 2012
Metformin has been reported to lower cancer incidence among type II diabetics. Metformin exhibits antiproliferative and antineoplastic effects associated with inhibition of mammalian target of rapamycin complex 1 (mTORC1), but the mechanisms are poorly understood.
Larsson, Ola, Morita, Masahiro, Topisirovic, Ivan, Alain, Tommy, Blouin, Marie-Jose, Pollak, Michael, Sonenberg, Nahum   +6 more
openaire   +3 more sources