Results 51 to 60 of about 4,258 (187)

Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amygdala

eLife, 2019
Local translation can support memory consolidation by supplying new proteins to synapses undergoing plasticity. Translation in adult forebrain dendrites is an established mechanism of synaptic plasticity and is regulated by learning, yet there is no ...
Linnaea E Ostroff, Emanuela Santini, Robert Sears, Zachary Deane, Rahul N Kanadia, Joseph E LeDoux, Tenzin Lhakhang, Aristotelis Tsirigos, Adriana Heguy, Eric Klann   +9 more
doaj   +1 more source

Stable maternal proteins underlie distinct transcriptome, translatome, and proteome reprogramming during mouse oocyte-to-embryo transition

Genome Biology, 2023
Background The oocyte-to-embryo transition (OET) converts terminally differentiated gametes into a totipotent embryo and is critically controlled by maternal mRNAs and proteins, while the genome is silent until zygotic genome activation.
Hongmei Zhang, Shuyan Ji, Ke Zhang, Yuling Chen, Jia Ming, Feng Kong, Lijuan Wang, Shun Wang, Zhuoning Zou, Zhuqing Xiong, Kai Xu, Zili Lin, Bo Huang, Ling Liu, Qiang Fan, Suoqin Jin, Haiteng Deng, Wei Xie   +17 more
doaj   +1 more source

Integrated Transcriptomic and Translatomic Inquiry of the Role of Betaine on Lipid Metabolic Dysregulation Induced by a High-Fat Diet

Frontiers in Nutrition, 2021
An excessive high-fat/energy diet is a major cause of obesity and linked complications, such as non-alcoholic fatty liver disease (NAFLD). Betaine has been shown to effectively improve hepatic lipid metabolism.
Tengda Huang, Lin Yu, Hongyuan Pan, Zeqiang Ma, Tian Wu, Lifang Zhang, Kang Liu, Qi Qi, Weiwei Miao, Ziyi Song, Haojie Zhang, Lei Zhou, Yixing Li   +12 more
doaj   +1 more source

G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?

Frontiers in Endocrinology, 2018
G protein-coupled receptors (GPCRs) exert their physiological function by transducing a complex signaling network that coordinates gene expression and dictates the phenotype of highly differentiated cells.
Aurélie Tréfier, Aurélie Tréfier, Aurélie Tréfier, Aurélie Tréfier, Lucie P. Pellissier, Lucie P. Pellissier, Lucie P. Pellissier, Lucie P. Pellissier, Astrid Musnier, Astrid Musnier, Astrid Musnier, Astrid Musnier, Eric Reiter, Eric Reiter, Eric Reiter, Eric Reiter, Florian Guillou, Florian Guillou, Florian Guillou, Florian Guillou, Pascale Crépieux, Pascale Crépieux, Pascale Crépieux, Pascale Crépieux   +23 more
doaj   +1 more source

Translation control can shape TP53-dependent cell fate

Molecular & Cellular Oncology, 2020
The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2 and, particularly, DHX30.
Dario Rizzotto, Sara Zaccara, Annalisa Rossi, Erik Dassi, Alberto Inga   +4 more
doaj   +1 more source

A vast evolutionarily transient translatome contributes to phenotype and fitness - Deletion screen data

, 2022
Data associated with the deletion screens presented in 'A vast evolutionarily transient translatome contributes to phenotype and fitness.'
Saurin Parikh (14271167), Nelson Castilho Coelho (9766552), Aaron Wacholder (14278417)   +2 more
core   +1 more source

Unbiased translation proteomics upon cell stress

Molecular & Cellular Oncology, 2020
The mammalian target of rapamycin and the integrated stress response are central cellular hubs regulating translation upon stress. The precise proteins and pathway specificity of translation targets of these pathways remained largely unclear. We recently
Kevin Klann, Christian Münch
doaj   +1 more source

Translatome-Interactome Analysis Sweave Documentation

, 2014
This Sweave document is designed to outline the set-up and running of MARINa on saline- and MPTP-specific translatome. The document is prepared as a Sweave document, and will run the analysis documented in the paper and output the full results.
William Shin (520087)
core   +1 more source

Glial control of the local translatome in AD [PDF]

Alzheimer's & Dementia, 2020
AbstractBackgroundUnder pathological conditions axons respond to Aβ oligomers by increasing localized translation which in turn contributes to neurodegeneration. Additionally, a link between intra‐dendritic translation, and Tau mislocalization and hyperphosphorilation has been found.
María Gamarra, Maite Blanco‐Urrejola, Jimena Baleriola   +2 more
openaire   +1 more source

Regulation of the hippocampal translatome by Apoer2-ICD release

Molecular Neurodegeneration, 2023
Abstract Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal compartment and prevents its normal recycling.
Catherine R. Wasser, Gordon C. Werthmann, Eric M. Hall, Kristina Kuhbandner, Connie H. Wong, Murat S. Durakoglugil, Joachim Herz   +6 more
openaire   +3 more sources