Results 31 to 40 of about 5,654 (195)
The translatome of Glioblastoma multiforme
, 2022 Abstract Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumor, containing intrinsic resistance to current therapies leading to poor clinical outcomes. Therefore, understanding the underlying mechanisms of GBM is an urgent medical need. Although radiotherapy contributes significantly to patient survival, GBMs recur
F. M.G. Cornelissen +9 more
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The Plant Translatome Surveyed by Ribosome Profiling [PDF]
Plant and Cell Physiology, 2019 Abstract Although transcriptome changes have long been recognized as a mechanism to induce tentative substitution of expressed genes in diverse biological processes in plants, the regulation of translation—the final step of the central dogma of molecular biology—emerged as an alternative and prominent layer in defining the output of ...
Tomoya Fujita +2 more
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A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome
Nature Communications, 2021 Here, Kim et al. apply various sequencing techniques (RPF-seq, QTI-seq, mRNA-seq, sRNA-seq) to unravel the high-resolution, longitudinal translatome and transcriptome of SARS-CoV-2.
Doyeon Kim +14 more
doaj +1 more source
Antioxidants, 2022 Soybean (Glycine max (L.) Merr.) establishes symbiosis with rhizobacteria, developing the symbiotic nodule, where the biological nitrogen fixation (BNF) occurs.
María Martha Sainz +5 more
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Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements [PDF]
Analytical Chemistry, 2020 Pulsed Stable Isotope Labeling in Cell culture (SILAC) approaches allow measurement of protein dynamics, including protein translation and degradation. However, its use for quantifying acute changes has been limited due to low labeled peptide stoichiometry.
Kevin Klann, Christian Münch
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Pharmaceutics, 2022 The present study aimed to better understand the possibility of utilizing all-trans retinoic acids (ATRA) in acute myeloid leukemia (AML). We found that ATRA significantly suppressed global translation and protein synthesis in AML cells.
Ke Wang +8 more
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Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2, and cytoskeletal remodeling in Schwann cells [PDF]
, 2018 Schwann cells are key players in neuro-regeneration: They sense "alarm" signals released by degenerating nerve terminals and differentiate toward a proregenerative phenotype, with phagocytosis of nerve debris and nerve guidance.
Duregotti, E +10 more
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BMC Genomics, 2012 Background The classical view on eukaryotic gene expression proposes the scheme of a forward flow for which fluctuations in mRNA levels upon a stimulus contribute to determine variations in mRNA availability for translation. Here we address this issue by
Tebaldi Toma +6 more
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Translational changes induced by acute sleep deprivation uncovered by TRAP-Seq
Molecular Brain, 2020 Sleep deprivation is a global health problem adversely affecting health as well as causing decrements in learning and performance. Sleep deprivation induces significant changes in gene transcription in many brain regions, with the hippocampus ...
Lisa C. Lyons +4 more
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Translatome Regulation in Neuronal Injury and Axon Regrowth [PDF]
eneuro, 2018 Abstract Transcriptional events leading to outgrowth of neuronal axons have been intensively studied, but the role of translational regulation in this process is not well understood. Here, we use translatome analyses by ribosome pull-down and protein synthesis characterization by metabolic isotopic labeling to study nerve injury and ...
Meir Rozenbaum +11 more
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