Results 31 to 40 of about 361 (118)
mSystems, 2021 Cyanobacteria are promising industrial platforms owing to their ability to produce diverse natural secondary metabolites and nonnative value-added biochemicals from CO2 and light.
Sang-Hyeok Cho +8 more
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Astonishing advances in mouse genetic tools for biomedical research
Swiss Medical Weekly, 2015 The humble house mouse has long been a workhorse model system in biomedical research. The technology for introducing site-specific genome modifications led to Nobel Prizes for its pioneers and opened a new era of mouse genetics.
Walker Scot Jackson, Lech Kaczmarczyk
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Effects of Kasugamycin on the Translatome of Escherichia coli
PLOS ONE, 2017 It is long known that Kasugamycin inhibits translation of canonical transcripts containing a 5'-UTR with a Shine Dalgarno (SD) motif, but not that of leaderless transcripts. To gain a global overview of the influence of Kasugamycin on translation efficiencies, the changes of the translatome of Escherichia coli induced by a 10 minutes Kasugamycin ...
Lange, Christian +7 more
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Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amygdala
eLife, 2019 Local translation can support memory consolidation by supplying new proteins to synapses undergoing plasticity. Translation in adult forebrain dendrites is an established mechanism of synaptic plasticity and is regulated by learning, yet there is no ...
Linnaea E Ostroff +9 more
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Genome Biology, 2023 Background The oocyte-to-embryo transition (OET) converts terminally differentiated gametes into a totipotent embryo and is critically controlled by maternal mRNAs and proteins, while the genome is silent until zygotic genome activation.
Hongmei Zhang +17 more
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G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?
Frontiers in Endocrinology, 2018 G protein-coupled receptors (GPCRs) exert their physiological function by transducing a complex signaling network that coordinates gene expression and dictates the phenotype of highly differentiated cells.
Aurélie Tréfier +23 more
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Translation control can shape TP53-dependent cell fate
Molecular & Cellular Oncology, 2020 The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2 and, particularly, DHX30.
Dario Rizzotto +4 more
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Frontiers in Nutrition, 2021 An excessive high-fat/energy diet is a major cause of obesity and linked complications, such as non-alcoholic fatty liver disease (NAFLD). Betaine has been shown to effectively improve hepatic lipid metabolism.
Tengda Huang +12 more
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Unbiased translation proteomics upon cell stress
Molecular & Cellular Oncology, 2020 The mammalian target of rapamycin and the integrated stress response are central cellular hubs regulating translation upon stress. The precise proteins and pathway specificity of translation targets of these pathways remained largely unclear. We recently
Kevin Klann, Christian Münch
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Regulation of the hippocampal translatome by Apoer2-ICD release
Molecular Neurodegeneration, 2023 Abstract Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal compartment and prevents its normal recycling.
Catherine R. Wasser +6 more
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