Results 11 to 20 of about 361 (118)
Legume-rhizobia symbiosis: Translatome analysis [PDF]
Genetics and Molecular BiologyLeguminous plants can establish endosymbiotic relationships with nitrogen-fixing soil rhizobacteria. Bacterial infection and nodule organogenesis are two independent but highly coordinated genetic programs that are active during this interaction.
María Martha Sainz +3 more
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Stress-dependent coordination of transcriptome and translatome in yeast. [PDF]
PLoS Biology, 2009 Cells rapidly alter gene expression in response to environmental stimuli such as nutrients, hormones, and drugs. During the imposed "remodeling" of gene expression, changes in the levels of particular mRNAs do not necessarily correlate with those of the ...
Regula E Halbeisen, André P Gerber
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Insights Into Translatomics in the Nervous System [PDF]
Frontiers in Genetics, 2020 Most neurological disorders are caused by abnormal gene translation. Generally, dysregulation of elements involved in the translational process disrupts homeostasis in neurons and neuroglia. Better understanding of how the gene translation process occurs requires detailed analysis of transcriptomic and proteomic profile data.
Shuxia Zhang +6 more
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Translatomics: The Global View of Translation [PDF]
International Journal of Molecular Sciences, 2019 In all kingdoms of life, proteins are synthesized by ribosomes in a process referred to as translation. The amplitude of translational regulation exceeds the sum of transcription, mRNA degradation and protein degradation. Therefore, it is essential to investigate translation in a global scale.
Jing Zhao +4 more
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The pathogenesis of mesothelioma is driven by a dysregulated translatome [PDF]
Nature Communications, 2021 Abstract Malignant mesothelioma (MpM) is an aggressive, invariably fatal tumour that is causally linked with asbestos exposure. The disease primarily results from loss of tumour suppressor gene function and there are no ‘druggable’ driver oncogenes associated with MpM.
Grosso, Stefano +27 more
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Transcriptome and translatome co-evolution in mammals [PDF]
Nature, 2020 Gene-expression programs define shared and species-specific phenotypes, but their evolution remains largely uncharacterized beyond the transcriptome layer1. Here we report an analysis of the co-evolution of translatomes and transcriptomes using ribosome-profiling and matched RNA-sequencing data for three organs (brain, liver and testis) in five mammals
Zhong-Yi Wang +16 more
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A post-transcriptional regulatory landscape of aging in the female mouse hippocampus
Frontiers in Aging Neuroscience, 2023 Aging is associated with substantial physiological changes and constitutes a major risk factor for neurological disorders including dementia. Alterations in gene expression upon aging have been extensively studied; however, an in-depth characterization ...
Raphaelle Winsky-Sommerer +4 more
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The translatome of neuronal cell bodies, dendrites, and axons [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance Proteins are the key drivers of neuronal synaptic function. The regulation of gene expression is important for the formation and modification of synapses throughout the lifespan. The complexity of dendrites and axons imposes unique challenges for protein supply at remote locations.
Glock, Caspar +7 more
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A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome
Nature Communications, 2021 Here, Kim et al. apply various sequencing techniques (RPF-seq, QTI-seq, mRNA-seq, sRNA-seq) to unravel the high-resolution, longitudinal translatome and transcriptome of SARS-CoV-2.
Doyeon Kim +14 more
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Antioxidants, 2022 Soybean (Glycine max (L.) Merr.) establishes symbiosis with rhizobacteria, developing the symbiotic nodule, where the biological nitrogen fixation (BNF) occurs.
María Martha Sainz +5 more
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