Results 11 to 20 of about 5,654 (195)

Legume-rhizobia symbiosis: Translatome analysis [PDF]

Genetics and Molecular Biology
Leguminous plants can establish endosymbiotic relationships with nitrogen-fixing soil rhizobacteria. Bacterial infection and nodule organogenesis are two independent but highly coordinated genetic programs that are active during this interaction.
María Martha Sainz, Mariana Sotelo-Silveira, Carla V. Filippi, Sofía Zardo   +3 more
doaj   +3 more sources

RiboMicrobe: An Integrated Translatome Atlas for Microorganism. [PDF]

Adv Sci (Weinh)
RiboMicrobe is a comprehensive database for Ribo‐seq data from prokaryotes, featuring 891 Ribo‐seq, 369 RNA‐seq, and 62 proteome datasets from 38 species. The database not only provides various data visualization results but also includes two sORF prediction models and a suit of bioinformatics tools for comparative analysis, facilitating easy access ...
Zhou Y, Luo J, Lang X, Gan Y, Liu G, Cui Y, Li F, Zhu W, Chen B, Dong Y, Wu Y, Cao Y, Liu Q.   +12 more
europepmc   +3 more sources

The translatome of glioblastoma

Molecular Oncology
Glioblastoma (GB), the most common and aggressive brain tumor, demonstrates intrinsic resistance to current therapies, resulting in poor clinical outcomes.
Fleur M. G. Cornelissen, Zhaoren He, Edward Ciputra, Richard R. deHaas, Ammarina Beumer‐Chuwonpad, David Noske, W. Peter Vandertop, Sander R. Piersma, Connie R. Jiménez, Cornelis Murre, Bart A. Westerman   +10 more
doaj   +3 more sources

Stress-dependent coordination of transcriptome and translatome in yeast. [PDF]

PLoS Biology, 2009
Cells rapidly alter gene expression in response to environmental stimuli such as nutrients, hormones, and drugs. During the imposed "remodeling" of gene expression, changes in the levels of particular mRNAs do not necessarily correlate with those of the ...
Regula E Halbeisen, André P Gerber
doaj   +7 more sources

Maize Anther Development Involves Translated Open Reading Frames From 3' Untranslated Regions. [PDF]

Adv Sci (Weinh)
This study examined the translation activity across ten stages of maize anther development, integrating transcriptome and small‐peptide data. It linked mutations in translated 3' ORFs to anther sterility, exemplified by Zm00001eb417050_3' ORF (known as APV1). In addition, the data indicated that maize anthers could assimilate CO2 through the stomata in
Wang C, Wu Y, Wang S, Liu H, Jiang S, Han Y, Wu L, Zhang T, Zhang M.   +8 more
europepmc   +2 more sources

Translatome and Transcriptome Profiling of Hypoxic-Induced Rat Cardiomyocytes [PDF]

Molecular Therapy: Nucleic Acids, 2020
Adult cardiac hypoxia as a crucial pathogenesis factor can induce detrimental effects on cardiac injury and dysfunction. The global transcriptome and translatome reflecting the cellular response to hypoxia have not yet been extensively studied in ...
Zhijie Shen, Lixiong Zeng, Zhihui Zhang
doaj   +3 more sources

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine-dependent Tumor Subset Under Metabolic Relationships With CAFs. [PDF]

Adv Sci (Weinh)
Researchers identified a pancreatic cancer subset with low global protein synthesis but heightened translation of stress‐response genes like ATF4, rendering cells resistant to chemotherapy and apoptosis. These tumors depend on serine and cysteine from surrounding cancer‐associated fibroblasts (CAFs), which shift to produce serine by curbing collagen ...
Shin S, Liauzun M, Solorzano J, Bras ML, Jean C, Fourneaux B, Dore M, Fevrier L, Belhabib I, Brunel A, Neuzillet C, Larroque M, Joffre C, Rocchi S, Fraunhoffer N, Perraud A, Mathonnet M, Pancaldi V, Linares L, Iovanna J, Dusetti N, Larsson O, Nicolle R, Pyronnet S, Bousquet C, Martineau Y.   +25 more
europepmc   +2 more sources

Multi-Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs. [PDF]

Adv Sci (Weinh)
Integrated multi‐omics across pig breeds and tissues reveals key principles of post‐transcriptional translational regulation and their contribution to trait formation. A gene network framework integrating transcriptomic and translatomic data is developed and applied to elucidate the genetic basis of meat production, offering new insights into mammalian
Wang C, Zhang Y, Chen C, Xu X, Qin S, Qi J, Bao Y, Li H, Chen R, Zheng W, Chen Z, Fang L, Zhao Y, Liu Y.   +13 more
europepmc   +2 more sources

Local translatome sustains synaptic function in impaired Wallerian degeneration [PDF]

EMBO Reports
After injury, severed axons separated from their somas activate programmed axon degeneration, a conserved pathway to initiate their degeneration within a day.
Maria Paglione, Leonardo Restivo, Sarah Zakhia, Arnau Llobet Rosell, Marco Terenzio, Lukas J Neukomm   +5 more
doaj   +3 more sources

Transcriptome and translatome co-evolution in mammals [PDF]

Nature, 2020
Gene-expression programs define shared and species-specific phenotypes, but their evolution remains largely uncharacterized beyond the transcriptome layer1. Here we report an analysis of the co-evolution of translatomes and transcriptomes using ribosome-profiling and matched RNA-sequencing data for three organs (brain, liver and testis) in five mammals
Zhong-Yi Wang, Evgeny Leushkin, Angélica Liechti, Svetlana Ovchinnikova, Katharina Mößinger, Thoomke Brüning, Coralie Rummel, Frank Grützner, Margarida Cardoso-Moreira, Peggy Janich, David Gatfield, Boubou Diagouraga, Bernard de Massy, Mark E. Gill, Antoine H. F. M. Peters, Simon Anders, Henrik Kaessmann   +16 more
openaire   +3 more sources