Results 1 to 10 of about 361 (118)

The Translatome of Glioblastoma

open access: yesMolecular Oncology
Glioblastoma (GB), the most common and aggressive brain tumor, demonstrates intrinsic resistance to current therapies, resulting in poor clinical outcomes.
Connie Jimenez   +2 more
exaly   +4 more sources

Dynamic Patterns of the Translatome in a Hybrid Triplet Show Translational Fractionation of the Maize Subgenomes

open access: yesCrop Journal, 2022
Heterosis, the phenomenon in which hybrids outperform their parents, has been utilized in maize (Zea mays L.) for over 100 years. To provide a more complete understanding of heterosis, we collected a comprehensive transcriptome and translatome dataset on
Lin Li, Jia Qian, Zi Luo
exaly   +3 more sources

Translatome and Transcriptome Profiling of Neonatal Mice Hippocampus Exposed to Sevoflurane Anesthesia

open access: yesHeliyon
Exposure to anesthesia in early life may cause severe damage to the brain and lead to cognitive impairment. The underlying mechanisms, which have only been investigated in a limited scale, remains largely elusive.
Hecheng Yang
exaly   +3 more sources

Translatome and Transcriptome Profiling of Hypoxic-Induced Rat Cardiomyocytes

open access: yesMolecular Therapy - Nucleic Acids, 2020
Adult cardiac hypoxia as a crucial pathogenesis factor can induce detrimental effects on cardiac injury and dysfunction. The global transcriptome and translatome reflecting the cellular response to hypoxia have not yet been extensively studied in ...
Lixiong Zeng, Zhihui Zhang
exaly   +3 more sources

Delayed Protein Changes During Seed Germination

open access: yesFrontiers in Plant Science, 2021
Over the past decade, ample transcriptome data have been generated at different stages during seed germination; however, far less is known about protein synthesis during this important physiological process.
Bing Bai   +9 more
doaj   +1 more source

Differential Regulation of the Ribosomal Association of mRNA Transcripts in an Arabidopsis Mutant Defective in Jasmonate-Dependent Wound Response

open access: yesFrontiers in Plant Science, 2021
Jasmonoyl-L-isoleucine (JA-Ile) is a powerful oxylipin responsible for the genome-wide transcriptional reprogramming in plants that results in major physiological shifts from growth to defense.
Athen Kimberlin   +5 more
doaj   +1 more source

A translatome-transcriptome multi-omics gene regulatory network reveals the complicated functional landscape of maize

open access: yesGenome Biology, 2023
Background Maize (Zea mays L.) is one of the most important crops worldwide. Although sophisticated maize gene regulatory networks (GRNs) have been constructed for functional genomics and phenotypic dissection, a multi-omics GRN connecting the ...
Wanchao Zhu   +10 more
doaj   +1 more source

Preferential Ribosome Loading on the Stress-Upregulated mRNA Pool Shapes the Selective Translation under Stress Conditions

open access: yesPlants, 2021
The reprogramming of gene expression is one of the key responses to environmental stimuli, whereas changes in mRNA do not necessarily bring forth corresponding changes of the protein, which seems partially due to the stress-induced selective translation.
Yan Chen, Min Liu, Zhicheng Dong
doaj   +1 more source

Trap-TRAP, a Versatile Tool for Tissue-Specific Translatomics in Zebrafish

open access: yesFrontiers in Cell and Developmental Biology, 2022
Developmental and physiological processes depend on the transcriptional and translational activity of heterogeneous cell populations. A main challenge in gene expression studies is dealing with this intrinsic complexity while keeping sequencing ...
Jorge Corbacho   +4 more
doaj   +1 more source

Lost in Translation: Physiological Roles of Stored mRNAs in Seed Germination

open access: yesPlants, 2020
Seeds characteristics such as germination ability, dormancy, and storability/longevity are important traits in agriculture, and various genes have been identified that are involved in its regulation at the transcriptional and post-transcriptional level ...
Naoto Sano   +2 more
doaj   +1 more source

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