Results 21 to 30 of about 361 (118)
Tissue- and stage-specific landscape of the mouse translatome [PDF]
Nucleic Acids Research, 2021 Abstract The current understanding of how overall principles of translational control govern the embryo-to-adult transition in mammals is still far from comprehensive. Herein we profiled the translatomes and transcriptomes of six tissues from the mice at embryonic and adult stages and presented the first report of tissue- and stage ...
Hongwei Wang +10 more
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Pharmaceutics, 2022 The present study aimed to better understand the possibility of utilizing all-trans retinoic acids (ATRA) in acute myeloid leukemia (AML). We found that ATRA significantly suppressed global translation and protein synthesis in AML cells.
Ke Wang +8 more
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BMC Genomics, 2012 Background The classical view on eukaryotic gene expression proposes the scheme of a forward flow for which fluctuations in mRNA levels upon a stimulus contribute to determine variations in mRNA availability for translation. Here we address this issue by
Tebaldi Toma +6 more
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Translational changes induced by acute sleep deprivation uncovered by TRAP-Seq
Molecular Brain, 2020 Sleep deprivation is a global health problem adversely affecting health as well as causing decrements in learning and performance. Sleep deprivation induces significant changes in gene transcription in many brain regions, with the hippocampus ...
Lisa C. Lyons +4 more
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The Plant Translatome Surveyed by Ribosome Profiling [PDF]
Plant and Cell Physiology, 2019 Abstract Although transcriptome changes have long been recognized as a mechanism to induce tentative substitution of expressed genes in diverse biological processes in plants, the regulation of translation—the final step of the central dogma of molecular biology—emerged as an alternative and prominent layer in defining the output of ...
Tomoya Fujita +2 more
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The translatome of Glioblastoma multiforme
, 2022 Abstract Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumor, containing intrinsic resistance to current therapies leading to poor clinical outcomes. Therefore, understanding the underlying mechanisms of GBM is an urgent medical need. Although radiotherapy contributes significantly to patient survival, GBMs recur
F. M.G. Cornelissen +9 more
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Selection of Cashmere Fineness Functional Genes by Translatomics [PDF]
Frontiers in Genetics, 2022 Cashmere fineness is an important index to evaluate cashmere quality. Liaoning Cashmere Goat (LCG) has a large cashmere production and long cashmere fiber, but its fineness is not ideal. Therefore, it is important to find genes involved in cashmere fineness that can be used in future endeavors aiming to improve this phenotype.
Yu Zhang +11 more
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Molecular Mechanisms of Persistence in Protozoan Parasites
Microorganisms, 2023 Protozoan parasites are known for their remarkable capacity to persist within the bodies of vertebrate hosts, which frequently results in prolonged infections and the recurrence of diseases.
Asfiha Tarannum +3 more
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Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation
eLife, 2020 Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but little is known about their characteristic gene expression profiles.
Ankit Jambusaria +8 more
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Inhibition of protein translation under matrix-deprivation stress in breast cancer cells
Frontiers in Medicine, 2023 Matrix-deprivation stress leads to cell-death by anoikis, whereas overcoming anoikis is critical for cancer metastasis. Work from our lab and others has identified a crucial role for the cellular energy sensor AMPK in anoikis-resistance, highlighting a ...
Shweta Warrier +3 more
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