Results 21 to 30 of about 4,258 (187)
Affinity purification of ribosomes to access the translatome.
Methods, 2020 We describe ribosome affinity purification (RAP), a method that allows rapid purification of ribosomes and associated messages from the yeast Saccharomyces cerevisiae.
Gerber, AP +2 more
core +6 more sources
Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. [PDF]
PLoS Genetics, 2012 Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism, whereas the status of protein metabolism is not well studied.
Suneng Fu +6 more
doaj +3 more sources
Isolating and Characterizing the Translatome From Human Alzheimer's Disease (AD) Brains
BJPsych OpenAims Local protein synthesis at the synapse is a key determinant of learning and memory and is predicted to be severely disrupted in Alzheimer's disease (AD).
Muhammad Ali Bangash, Julie Qiaojin Lin
doaj +2 more sources
BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells. [PDF]
Adv Sci (Weinh)BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Li X +8 more
europepmc +2 more sources
Insights Into Translatomics in the Nervous System [PDF]
Frontiers in Genetics, 2020 Most neurological disorders are caused by abnormal gene translation. Generally, dysregulation of elements involved in the translational process disrupts homeostasis in neurons and neuroglia. Better understanding of how the gene translation process occurs requires detailed analysis of transcriptomic and proteomic profile data.
Shuxia Zhang +6 more
openaire +3 more sources
Adaptive Translatome Reprogramming in Response to Anaerobiosis [PDF]
, 2022 Protein expression evolves under greater evolutionary constraint than mRNA levels, and translation efficiency represents a primary determinant of protein levels during stimuli adaptation. This raises the question: what are the translatome remodelers that
Balukoff, Nathan
core +4 more sources
The pathogenesis of mesothelioma is driven by a dysregulated translatome [PDF]
Nature Communications, 2021 AbstractMalignant mesothelioma (MpM) is an aggressive, invariably fatal tumour that is causally linked with asbestos exposure. The disease primarily results from loss of tumour suppressor gene function and there are no ‘druggable’ driver oncogenes associated with MpM. To identify opportunities for management of this disease we have carried out polysome
Grosso, Stefano +27 more
openaire +5 more sources
Translatomics: The Global View of Translation [PDF]
International Journal of Molecular Sciences, 2019 In all kingdoms of life, proteins are synthesized by ribosomes in a process referred to as translation. The amplitude of translational regulation exceeds the sum of transcription, mRNA degradation and protein degradation. Therefore, it is essential to investigate translation in a global scale.
Jing Zhao +4 more
openaire +2 more sources
Plants, 2021 The reprogramming of gene expression is one of the key responses to environmental stimuli, whereas changes in mRNA do not necessarily bring forth corresponding changes of the protein, which seems partially due to the stress-induced selective translation.
Yan Chen, Min Liu, Zhicheng Dong
doaj +1 more source
Trap-TRAP, a Versatile Tool for Tissue-Specific Translatomics in Zebrafish
Frontiers in Cell and Developmental Biology, 2022 Developmental and physiological processes depend on the transcriptional and translational activity of heterogeneous cell populations. A main challenge in gene expression studies is dealing with this intrinsic complexity while keeping sequencing ...
Jorge Corbacho +4 more
doaj +1 more source