Results 41 to 50 of about 361 (118)

Glial control of the local translatome in AD [PDF]

Alzheimer's & Dementia, 2020
AbstractBackgroundUnder pathological conditions axons respond to Aβ oligomers by increasing localized translation which in turn contributes to neurodegeneration. Additionally, a link between intra‐dendritic translation, and Tau mislocalization and hyperphosphorilation has been found.
María Gamarra, Maite Blanco‐Urrejola, Jimena Baleriola   +2 more
openaire   +1 more source

Bridging the gap between genomic, phenotypic, and modeling data in picophytoplankton–virus interactions

Journal of Phycology, EarlyView.
Abstract We present a comprehensive synthesis of recent developments in methodological approaches to combine experimental and genomic studies of picophytoplankton–virus interactions. This synthesis will not only enhance our understanding of these relationships but also stimulate new hypotheses for the interpretation of metagenomic data and enrich ...
Luisa Listmann, Carina Peters, Anais Labecot, Raphaël Rousseau, Christie Baux, Maria Elisabetta Santelia, Eric Manirakiza, Nigel Grimsley, Sheree Yau, Sébastien Gourbiere, C‐Elisa Schaum, Gwenael Piganeau   +11 more
wiley   +1 more source

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

Nature Communications, 2022
Alzheimer’s disease is associated with changes in astrocytes. Here the authors investigated the astrocyte translatome associated with amyloid-ß and tau pathology.
Zoeb Jiwaji, Sachin S. Tiwari, Rolando X. Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A. Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M. Smith, Peta Greer, Matthew Ball, Peter C. Kind, Paul M. Matthews, Colin Smith, Owen Dando, Tara L. Spires-Jones, Jeffrey A. Johnson, Siddharthan Chandran, Giles E. Hardingham   +30 more
doaj   +1 more source

Peripheral regeneration of Aβ low‐threshold mechanoreceptors is limited despite activation of regenerative transcriptional pathways

The Journal of Physiology, EarlyView.
Abstract figure legend The regeneration of Aβ low‐threshold mechanoreceptors (Aβ‐LTMRs), sensory neurons responsible for discriminative touch, has not previously been explored. Here, we took advantage of the selective expression of Calb1 in Aβ‐LTMRs to generate two genetic mouse models for studying their regenerative response after nerve injury.
Sara Bolívar, Natàlia Martínez‐Mateu, David Ovelleiro, Esther Udina   +3 more
wiley   +1 more source

Translatome Regulation in Neuronal Injury and Axon Regrowth [PDF]

eneuro, 2018
Abstract Transcriptional events leading to outgrowth of neuronal axons have been intensively studied, but the role of translational regulation in this process is not well understood. Here, we use translatome analyses by ribosome pull-down and protein synthesis characterization by metabolic isotopic labeling to study nerve injury and ...
Meir Rozenbaum, Marek Rajman, Ida Rishal, Indrek Koppel, Sandip Koley, Katalin F. Medzihradszky, Juan A. Oses-Prieto, Riki Kawaguchi, Paul S. Amieux, Alma L. Burlingame, Giovanni Coppola, Mike Fainzilber   +11 more
openaire   +5 more sources

Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity

Glia, Volume 74, Issue 12, December 2026.
The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, Volume 13, Issue 61, 3 November 2026.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

Deciphering transcriptome complexity via long‐read sequencing

iMeta, Volume 5, Issue 5, October 2026.
Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu, Jia Li, Chenxi Yin, Keying Li, Tian Wang, Shiwen Gao, Yue Yu, Cheng Chang, Ye Wang, Guoqing Tong, Liang Gong, Wen Hu, Guoliang Chai, Yilai Han, Qian Qin, Suoqin Jin, Xiufen Zou, Bo Li, Tianyuan Zhang, Ana Conesa, Yunhao Wang, Dingjie Wang   +21 more
wiley   +1 more source

Translational Control under Stress: Reshaping the Translatome [PDF]

BioEssays, 2019
Adequate reprogramming of cellular metabolism in response to stresses or suboptimal growth conditions involves a myriad of coordinated changes that serve to promote cell survival. As protein synthesis is an energetically expensive process, its regulation under stress is of critical importance.
Vivek M, Advani, Pavel, Ivanov
openaire   +2 more sources

Integrated Translatome and Proteome: Approach for Accurate Portraying of Widespread Multifunctional Aspects of Trichoderma

Frontiers in Microbiology, 2017
Genome-wide studies of transcripts expression help in systematic monitoring of genes and allow targeting of candidate genes for future research. In contrast to relatively stable genomic data, the expression of genes is dynamic and regulated both at time ...
Vivek Sharma, Richa Salwan, P. N. Sharma, Arvind Gulati   +3 more
doaj   +1 more source