Results 121 to 130 of about 698,201 (312)

Genetic outcomes from the translocations of the critically endangered woylie

Current Zoology, 2013
Translocations are an important conservation strategy for many species. However simply observing demographic growth of a translocated population is not sufficient to infer species recovery.
Carlo PACIONI, Adrian F.WAYNE, Peter B.S.SPENCER
doaj  

Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function.

, 2016
Rare genetic variants of large effect can help elucidate the pathophysiology of brain disorders. Here we expand the clinical and genetic analyses of a family with a (1;11)(q42;q14.3) translocation multiply affected by major psychiatric illness and test ...
Dauvermann, M.R., Bois, C., Roberts, N., van Beek, E.J., Porteous, D.J., Redpath, H., Romaniuk, L., Li, X., Watson, A., Hall, L., Moorhead, T.W., Ryan, N.M., St Clair, D., Whitcher, B., Duff, B., Blackwood, D.H., Dunlop, J., Thomson, P.A., Morris, S.W., Whalley, H.C.   +19 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Enrichment of 65Zn in two contrasting rice genotypes under varying methods of zinc application

Plant, Soil and Environment, 2014
Zinc (Zn) is an essential micronutrient for growth and development of almost all organisms and its deficiency severely affects the health of plants, animals and humans.
B. Mathpal, P.C. Srivastava, A.K. Shukla, D. Shankhdhar, S.C. Shankhdhar   +4 more
doaj   +1 more source

Translocation of DNA across bacterial membranes [PDF]

, 1994
Dreiseikelmann B. Translocation of DNA across bacterial membranes. Microbiological Reviews.
Dreiseikelmann, Brigitte
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP-ribosylating toxin AB to establish a persistent infection. [PDF]

FEBS Open Bio
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Zabala-Rodriguez MC, Tinker JK, Frisan T, Azarian T, Teter K.   +4 more
europepmc   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Translocation to prevent extinction in face of global change: the case of the sterile relict tree Zelkova sicula (Sicily, Italy)

, 2021
Presentazione dei risultati dell'attività di Species translocation relativi alla specie relitta Zelkova ...
Gristina AS, Pasta S, Buord S, Motisi A, Garfi' G, Catalano C, Kozlowski G, Carra A, Fazan L, Livreri Console S, Perrotta G, Gautier C   +11 more
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source