Results 61 to 70 of about 1,020,829 (348)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Predation impedes recovery of Sierra Nevada bighorn sheep

California Fish and Wildlife Journal, 2021
Translocation of animals into formerly occupied habitat is a key element of the recovery plan for Sierra Nevada bighorn sheep (Ovis canadensis sierrae), which are state (California) and federally listed as endangered. However, implementing Sierra bighorn
Daniel J. Gammons, Jeffrey L. Davis, David W. German, Kristin Denryter, John D. Wehausen, Thomas R. Stephenson   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Markovian Description of Unbiased Polymer Translocation [PDF]

, 2012
We perform, with the help of cloud computing resources, extensive Langevin simulations which provide compelling evidence in favor of a general markovian framework for unbiased polymer translocation.
Mondaini, Felipe, Moriconi, L.
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Whole‐Genome Analyses Reveal the Distinct Taxonomic Status of the Hainan Population of Endangered Rucervus eldii and Its Conservation Implications

Evolutionary Applications
Eld's deer Rucervus eldii (McClelland, 1842) is an ungulate that lives in tropical lowland forests in several countries of Indochina and Hainan Island of China.
Chenqing Zheng, Qing Chen, Michelle Hang Gi Wong, Nick Marx, Thananh Khotpathoom, Hesheng Wang, Feng Yang, Xiaodong Rao, Bosco Pui Lok Chan, Yang Liu   +9 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Diurnal roosts and minimum home range defined by sleeping sites of a thin-spined porcupine Chaetomys subspinosus (Rodentia: Erethizontidae)

Zoologia (Curitiba), 2010
The thin-spined porcupine Chaetomys subspinosus (Olfers, 1818) is a species endemic to the extremely disturbed and fragmented Brazilian Atlantic forest. Little is known about its natural history. We analyzed the preferences of porcupine diurnal roost and
Marlon Zortéa, Bernardo F. A. de Brito
doaj   +1 more source

Maternal 2:18 chromosomal translocation manifesting as cause for developmental delay in a proband

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2020
Developmental disabilities are a group of related chronic disorders of early onset and said to affect 5% to 10% children. Mental Retardation or intellectual disability has been redefined and replaced with Global developmental delay by WHO as the ...
Purushottam Rao Manvikar, Preeti Awari
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source