Results 111 to 120 of about 96,778 (277)

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source

Supporting long‐term engagement in HIV clinical care: Learning from the COVID‐19 pandemic

HIV Medicine, EarlyView.
Abstract Objectives SHIELD is a London‐based study of engagement in HIV clinical care during and after the COVID‐19 pandemic. We document the characteristics of service users who either re‐engaged or disengaged with HIV care, together with reflections of HIV clinical service‐providers to inform recommendations that address care retention for the long ...
R. Dhairyawan, Sara Paparini, M. Smuk, S. Sidat, R. Mbewe, Silvia Petretti, V. Martin, S. Dakshina, H. Alexander, T. D. Appleby, K. Childs, M. Bracchi, B. Dragovic, G. Haidari, N. Mackie, I. Reeves, A. Umaipalan, L. J. Waters, J. Anderson, C. M. Orkin   +19 more
wiley   +1 more source

Nonlinear multigrid based on local spectral coarsening for heterogeneous diffusion problems

, 2020
This work develops a nonlinear multigrid method for diffusion problems discretized by cell-centered finite volume methods on general unstructured grids.
Castelletto, Nicola, Hamon, François, Lee, Chak Shing, Vassilevski, Panayot S., White, Joshua   +4 more
core  

Blood Immunopathology of Tuberculosis Patients Disrupts Monocyte‐Dependent T‐Cell Activation and Cytokine Expression

Immunology, EarlyView.
TB serum selectively disrupts monocyte‐dependent PHA T cell activation and cytokines associated with proliferation while preserving SEB T cell and Pam3/PHA monocyte cytokine responses. ABSTRACT Pulmonary tuberculosis in humans is characterised by features of immunopathology, which influence both antimycobacterial therapy and the long‐term prognosis. In
Joseph F. Arthur, Hubert S. Ahor, Monika M. Vivekanandan, Difery Minadzi, Augustine Yeboah, Millicent Lamptey, Victoria A. Ofori, Albert D. Kegya, Rejoice Arthur, Linda A. Amoakoa, Ernest Adankwah, Dorcas O. Owusu, Mohammed K. Abass, Fredrick Gyamfi Apraku, Nana K. Ayisi‐Boateng, Seth Adane, Salisu Zakaria, Ertan Mayatepek, Julia Seyfarth, Richard O. Phillips, Marc Jacobsen   +20 more
wiley   +1 more source

Estimation of Genetic Variance and Breeding Values for Infectious Disease Susceptibility From Simulated Longitudinal Data Using Generalized Linear Mixed Models Based on Transmission Dynamics

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Recent theoretical work shows that the potential of genetic selection to reduce the prevalence of infectious diseases is much larger than expected from classical quantitative genetic theory, due to indirect genetic effects that arise in the transmission process. However, to fully benefit from these indirect effects, we need to estimate genetic
A. D. Hulst, R. Pong‐Wong, A. Doeschl‐Wilson, M. C. M. De Jong, P. Bijma   +4 more
wiley   +1 more source

Properties of highly clustered networks

, 2003
We propose and solve exactly a model of a network that has both a tunable degree distribution and a tunable clustering coefficient. Among other things, our results indicate that increased clustering leads to a decrease in the size of the giant component ...
A. Vázquez, A.-L. Barabási, D.J. Watts, D.J. Watts, E. Ravasz, F. Chung, H.W. Hethcote, K. Klemm, L.A.N. Amaral, L.M. Sander, M. E. J. Newman, M. Faloutsos, M. Girvan, M. Molloy, M. Molloy, M.E.J. Newman, M.E.J. Newman, M.E.J. Newman, M.E.J. Newman, P. Grassberger, P. Holme, R. Albert, R. Albert, R. Cohen, R.J. Riddell, Jr., S.H. Strogatz, S.N. Dorogovtsev, S.N. Dorogovtsev, Y. Moreno   +28 more
core   +1 more source

The dilemma of honey bee pest management in European Union: eradication or coexistence?

Insect Science, EarlyView.
Michela Bertola, Franco Mutinelli
wiley   +1 more source

Impact of Emergent Physician Notifications from Mobile Cardiac Outpatient Telemetry on Patient Outcomes (The EP‐COT Trial)

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Mobile ambulatory cardiac telemetry (MCOT) use has increased over time; however, data on the prevalence and the impact of emergent arrhythmia notifications with MCOT remains unclear. We sought to determine the prevalence and clinical impact of emergent arrhythmia events in patients undergoing MCOT monitoring.
David Lin, Sanchit Kumar, Khurram Butt, Jake Klewer, Mahesh Balakrishnan, Alvaro Altamirano, Aaron Vigdor, Andrea Schell, Purvee Parikh, C. J. Grigoriadis, Manish Wadhwa, Mathew D. Hutchinson   +11 more
wiley   +1 more source

Research Direction and Science Evaluation: The Role of Coherence and Alignment

Journal of Economics &Management Strategy, EarlyView.
ABSTRACT The decisions of funding agencies greatly influence the direction of scientific research; however, our understanding of how applicants' research directions affect the selection process remains limited. In this study, we investigate how a project's coherence with a scientist's previous work and its alignment with current scientific trends ...
Charles Ayoubi, Sandra Barbosu, Michele Pezzoni, Fabiana Visentin   +3 more
wiley   +1 more source

Linear Finite-Field Deterministic Networks With Many Sources and One Destination [PDF]

, 2010
We find the capacity region of linear finite-field deterministic networks with many sources and one destination. Nodes in the network are subject to interference and broadcast constraints, specified by the linear finite-field deterministic model.
Butt, M. Majid, Caire, Giuseppe, Müller, Ralf R.   +2 more
core   +1 more source