Results 51 to 60 of about 1,172,761 (182)

Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication.

PLoS Pathogens, 2021
Emerging coronaviruses (CoVs) pose a severe threat to human and animal health worldwide. To identify host factors required for CoV infection, we used α-CoV transmissible gastroenteritis virus (TGEV) as a model for genome-scale CRISPR knockout (KO ...
Limeng Sun, Changzhi Zhao, Zhen Fu, Yanan Fu, Zhelin Su, Yangyang Li, Yuan Zhou, Yubei Tan, Jingjin Li, Yixin Xiang, Xiongwei Nie, Jinfu Zhang, Fei Liu, Shuhong Zhao, Shengsong Xie, Guiqing Peng   +15 more
doaj   +1 more source

Protein-protein interaction (PPI) network of the selected DEGs visualized with Cytoscape (TMEM41B-KO-MOCK vs. TMEM41B-KO-TGEV).

, 2021
Differentially expressed genes in the "interferon signaling" pathway were marked with yellow. KO, knockout; TGEV, Transmissible gastroenteritis virus infected cells; Mock, uninfected cells. (TIF)
Limeng Sun (9321756), Jinfu Zhang (709197), Jingjin Li (4172617), Xiongwei Nie (9321744), Guiqing Peng (90055), Zhelin Su (11797970), Changzhi Zhao (1647001), Yanan Fu (4422967), Yuan Zhou (179597), Shengsong Xie (582082), Yubei Tan (11797973), Shuhong Zhao (48168), Yangyang Li (554659), Zhen Fu (669777), Yixin Xiang (11797976), Fei Liu (21082)   +15 more
core   +1 more source

Protein-protein interaction (PPI) network of the selected DEGs visualized with Cytoscape (WT-MOCK vs. WT-TGEV).

, 2021
Differentially expressed genes in the "interferon signaling" pathway were marked with yellow. WT, wild-type; TGEV, Transmissible gastroenteritis virus infected cells; Mock, uninfected cells. (TIF)
Limeng Sun (9321756), Jinfu Zhang (709197), Jingjin Li (4172617), Xiongwei Nie (9321744), Guiqing Peng (90055), Zhelin Su (11797970), Changzhi Zhao (1647001), Yanan Fu (4422967), Yuan Zhou (179597), Shengsong Xie (582082), Yubei Tan (11797973), Shuhong Zhao (48168), Yangyang Li (554659), Zhen Fu (669777), Yixin Xiang (11797976), Fei Liu (21082)   +15 more
core   +1 more source

L-Leucine Promotes STAT1 and ISGs Expression in TGEV-Infected IPEC-J2 Cells via mTOR Activation

Frontiers in Immunology, 2021
L-leucine (Leu), as one of the effective amino acids to activate the mTOR signaling pathway, can alleviate transmissible gastroenteritis virus (TGEV) infection.
Jian Du, Daiwen Chen, Bing Yu, Jun He, Jie Yu, Xiangbing Mao, Yuheng Luo, Ping Zheng, Junqiu Luo   +8 more
doaj   +1 more source

A competitive inhibition ELISA for the differentiation of serum antibodies from pigs infected with transmissible gastroenteritis virus (TGEV) or with the TGEV-related porcine respiratory coronavirus

Veterinary Microbiology, 1989
A competitive inhibition ELISA was developed to detect non-neutralizing antibodies to the peplomer protein of transmissible gastroenteritis virus (TGEV) in porcine sera using a monoclonal antibody as an indicator. It was demonstrated that field strains of the TGEV-related porcine respiratory coronavirus (PRCV) did not induce this antibody, whereas the ...
Callebaut, P., Pensaert, M.B., Hooyberghs, J.   +2 more
openaire   +2 more sources

Development of a Multiplex Quantitative PCR for Detecting Porcine Epidemic Diarrhea Virus, Transmissible Gastroenteritis Virus, and Porcine Deltacoronavirus Simultaneously in China

Veterinary Sciences, 2023
Porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) belong to the category of swine enteric coronavirus that cause acute diarrhea in piglets, which has resulted in massive losses to the
Jianpeng Chen, Rongchao Liu, Huaicheng Liu, Jing Chen, Xiaohan Li, Jianfeng Zhang, Bin Zhou   +6 more
doaj   +1 more source

microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro. [PDF]

Mol Cell Proteomics, 2018
Transmissible gastroenteritis virus (TGEV), a member of the coronaviridae family, could cause fatal diarrhea of piglets and result in numerous economic losses. Previous studies demonstrated that TGEV infection could lead to mitochondrial damage and upregulate miR-4331 level.
Zhao X, Bai X, Guan L, Li J, Song X, Ma X, Guo J, Zhang Z, Du Q, Huang Y, Tong D.   +10 more
europepmc   +3 more sources

Recombinant canine coronaviruses related to transmissible gastroenteritis virus of swine are circulating in dogs

, 2008
Four canine coronavirus type II (CCoV-II) strains were identified in the guts and internal organs of pups which had died of acute gastroenteritis. The CCoV-II strains were strictly related to porcine transmissible gastroenteritis virus (TGEV) in the N ...
BUONAVOGLIA, Canio, N. Decaro, MARTELLA, Vito, M. Camero, Lorusso, Alessio, G. Elia, Campolo, M, Cordioli, P, MARI, VIVIANA, L. Enjuanes, V. Mari, Enjuanes, L, A. Lorusso, Campolo, Marco, Enjuanes Sánchez, Luis, C. Buonavoglia, DECARO, Nicola, M. Campolo, P. Cordioli, ELIA, Gabriella, Lorusso, A, Cordioli, Paolo, CAMERO, Michele, V. Martella   +23 more
core   +1 more source

Evaluation on the efficacy and immunogenicity of recombinant DNA plasmids expressing spike genes from porcine transmissible gastroenteritis virus and porcine epidemic diarrhea virus. [PDF]

PLoS ONE, 2013
Porcine transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PDEV) can cause severe diarrhea in pigs. Development of effective vaccines against TGEV and PEDV is one of important prevention measures. The spike (S) protein is the
Fandan Meng, Yudong Ren, Siqingaowa Suo, Xuejiao Sun, Xunliang Li, Pengchong Li, Wei Yang, Guangxing Li, Lu Li, Christel Schwegmann-Wessels, Georg Herrler, Xiaofeng Ren   +11 more
doaj   +1 more source

MiniSdd7‐Derived Cytosine Base Editor Promotes Efficient Multiplex Gene Knockout in Porcine Primary Fibroblasts

Animal Research and One Health, EarlyView.
The miniSdd7‐BE4max‐SpG system enables highly efficient multiplex C‐to‐T base editing of APN, CD163, and MSTN in porcine fibroblasts, providing a robust platform for future development of multiplex gene‐edited livestock. ABSTRACT Efficient multiplex genome editing is essential for improving complex traits in livestock that are governed by multiple ...
Shaoshuai Wang, Yu Wang, Dengfeng Bi, Jianguo Zhao, Yanfang Wang   +4 more
wiley   +1 more source