Results 51 to 60 of about 889,883 (299)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A Preliminary Study on the Principle of Linear Effect Scaling Laws for Laser Atmospheric Transmission

Photonics
Numerical simulations were performed to rapidly predict and evaluate laser beam expansion caused by linear atmospheric transmission effects, such as turbulence and jitter, thereby enhancing the accuracy of the scaling law.
Xin Ye, Chengyu Fan, Wenyue Zhu, Pengfei Zhang, Xianmei Qian, Jinghui Zhang, Tao Jiang   +6 more
doaj   +1 more source

Network reinforcement requirements for Scotland and the rest of the UK (RUK) - and possible solutions for this [PDF]

, 2012
A novel multi-objective transmission expansion planning (MOTEP) tool has been developed to analyse, on a comprehensive geographical scale, the reinforcements required to a base case electrical transmission network following application of a chosen future
Ault, Graham, Barnacle, Malcolm
core  

Multiyear Transmission Expansion Planning Using Ordinal Optimization [PDF]

IEEE Transactions on Power Systems, 2007
The increasing complexity of the transmission expansion planning problem in the restructured industry makes simulation the only viable means to evaluate and compare the performances of different plans. Ordinal optimization is an approach suitable for solving the simulation-based multiyear transmission expansion planning problem.
Xie, M, Zhong, J, Wu, FF
openaire   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Joint Expansion Planning of Energy Storage and Transmission Considering Power System Flexibility

Zhongguo dianli, 2021
In order to accommodate high-penetration wind & PV power sources with strong fluctuation and randomness, the access of renewables and planning of transmission grids not only need to consider the balance of electricity, but also the balance of flexibility
Jiaming LI, Wenqi LI, Zongxiang LU, Ying QIAO, Dongxue GAO, Shaolin LIU   +5 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Multi-Year Stochastic Transmission Network Expansion Planning Considering Line Uprating

IEEE Access, 2021
Transmission network expansion planning (TNEP) has become increasingly challenging due to the worldwide transformation of power systems, with the fast deployment of renewable energies as one of the key drivers. Given current socio-environmental concerns,
Ricardo Alvarez, Claudia Rahmann, Nicolas Cifuentes, Rodrigo Palma-Behnke   +3 more
doaj   +1 more source

Broadband enhanced transmission through the stacked metallic multi-layers perforated with coaxial annular apertures

, 2011
This paper theoretically and experimentally presents a first report on broadband enhanced transmission through stacked metallic multi-layers perforated with coaxial annular apertures (CAAs).
Bahk, Baida, Barnes, Chan, de Abajo, Ebbesen, Fan, Fan, Gay, Ghaemi, Hongqiang Li, Lalanne, Liu, Marcet, Martin-Moreno, Miyamaru, Ortuno, Ruan, Sheng, Tang, van der Molen, Wei, Wei, Wei, Wei, Wen, Xiao, Xing Yu, Yang Cao, Ye, Yuancheng Fan, Zeyong Wei, Zhou   +32 more
core   +1 more source