Results 111 to 120 of about 1,701,551 (356)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Geriatric transplant anaesthesia

, 2015
The elderly comprise a growing fraction of the population with increasing demand for transplant services. Presently, 21% of subjects registered on the organ transplant list are older than 65 and around 18% of all transplants are carried out in the ...
Souki, Fouad G., Lewis, Michael C., Fouad G. Souki, Michael C. Lewis   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Screening of a HUVEC cDNA library with transplant-associated coronary artery disease sera identifies RPL7 as a candidate autoantigen associated with this disease. [PDF]

, 2001
A HUVEC cDNA library was screened with sera from two patients who had developed transplant-associated coronary artery disease (TxCAD) following cardiac transplantation.
Marchant, B., Linke, A.T., Murphy, John J., Linke, A T, Rose, Marlene L., Marchant, B, Rose, M L, Marsh, P, Murphy, J, Marsh, P., Frampton, Geoffrey, Frampton, G   +11 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Genetic immune and inflammatory markers associated with diabetes in solid organ transplant recipients

, 2019
New-onset diabetes mellitus after transplantation (NODAT) is a complication following solid organ transplantation (SOT) and may be related to immune or inflammatory responses.
Mueller, N.J., Soccal, P.M., Mohacsi, Paul, Golshayan, D., Golshayan, Dela, Dela Golshayan, Wójtowicz, A., Kutalik, Z., Crettol, Severine, Eap, Chin B, Crettol, S., Christoph Hess, Dufour, Jean-François Jacques, Steiger, Jürg, Pedro Marques-Vidal, Swiss Transplant Cohort Study, Mike Recher, Hess, Christoph, van Delden, C., Eap, C.B., Quteineh, Lina, Hess, C., Frederik Vandenberghe, Vandenberghe, Frederik, Vollenweider, Peter, Chin B. Eap, Lehmann, Roger, Severine Crettol, Pascual, Manuel, Soccal, Paola M, Dufour, Jean-Francois, Peter Vollenweider, Recher, Mike, Roger Lehmann, Eap, Chin Bin, Manuel, Oriol, Zoltan Kutalik, Agnieszka Wójtowicz, Manuel, O., Pierre-Yves Bochud, Christian van Delden, Recher, M., Nicolas J. Mueller, Manuel Pascual, Isabelle Binet, Kutalik, Zoltan, Vollenweider, P., Mohacsi, P., Oriol Manuel, Marques-Vidal, Pedro, Bochud, P.Y., Dufour, J.F., Marques-Vidal, P., Lina Quteineh, Pascual, Manuel Antonio, Jean-Pierre Venetz, Mueller, Nicolas J, Wójtowicz, Agnieszka, Quteineh, L., Vandenberghe, F., Binet, Isabelle, Jürg Steiger, Paola M. Soccal, Bochud, Pierre-Yves, van Delden, Christian, Binet, I., Venetz, J.P., Lehmann, R., Paul Mohacsi, Pascual, M., Steiger, J., Jean-Francois Dufour, Venetz, Jean-Pierre   +72 more
core   +1 more source

Clinical Grade Regulatory CD4+ T Cells (Tregs): Moving Toward Cellular-Based Immunomodulatory Therapies

Frontiers in Immunology, 2018
Regulatory T cells (Tregs) are CD4+ T cells that are key players of immune tolerance. They are powerful suppressor cells, able to impact the function of numerous immune cells, including key effectors of inflammation such as effector T cells.
Richard Duggleby, Richard Duggleby, Robert David Danby, Robert David Danby, Robert David Danby, J. Alejandro Madrigal, J. Alejandro Madrigal, Aurore Saudemont, Aurore Saudemont   +8 more
doaj   +1 more source

Practical Recommendations for Long-term Management of Modifiable Risks in Kidney and Liver Transplant Recipients: A Guidance Report and Clinical Checklist by the Consensus on Managing Modifiable Risk in Transplantation (COMMIT) Group

Transplantation, 2017
Short-term patient and graft outcomes continue to improve after kidney and liver transplantation, with 1-year survival rates over 80%; however, improving longer-term outcomes remains a challenge.
J. Neuberger, W. Bechstein, D. Kuypers, P. Burra, F. Citterio, S. D. De Geest, C. Duvoux, A. Jardine, N. Kamar, B. Krämer, H. Metselaar, F. Nevens, J. Pirenne, M. Rodríguez-Perálvarez, D. Samuel, S. Schneeberger, D. Serón, P. Trunec̃ka, G. Tisone, T. van Gelder   +19 more
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Donor-derived infections: The Swiss perspective. [PDF]

While Switzerland has not yet established a systematic approach, the small size of the country and the intensive collaboration between the transplant infectious disease teams facilitate a rapid communication once a donor-derived infection is suspected ...
Mueller, Nicolas J, Hirzel, Cédric, Manuel, Oriol, Hirzel, C., Mueller, N.J., Manuel, O.   +5 more
core   +1 more source