Results 101 to 110 of about 4,786,268 (341)

Impact of hematopoietic chimerism at day +14 on engraftment after unrelated donor umbilical cord blood transplantation for hematologic malignancies

Haematologica, 2009
Background Cord blood transplant is a feasible treatment alternative for adult patients with hematologic malignancies lacking a suitable HLA-matched donor.
Federico Moscardó, Jaime Sanz, Leonor Senent, Susana Cantero, Javier de la Rubia, Pau Montesinos, Dolores Planelles, Ignacio Lorenzo, Jose Cervera, Javier Palau, Miguel A. Sanz, Guillermo F. Sanz   +11 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Multiple Myeloma : an update on disease biology and therapy [PDF]

, 2004
Multiple myeloma is a malignancy of immunoglobulin producing plasma cells. Clinical features include bone pain due to lytic bone lesions or pathological fractures, anemia, symptomatic hypercalcemia, renal insufficiency, recurrent infections and ...
Cook, Rachel J., Dingli, David
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Steps in immunosuppression for renal transplantation [PDF]

, 1983
The authors provide a historical survey of the immunosuppressive agents that have been used to prevent allograft rejection.
Hakala, TR, Rosenthal, JT, Starzl, TE
core  

Immunomagnetic t-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody [PDF]

, 1989
Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (0×19) bound to monosized,
A. Pascualone, A.L. Hoffman, B.F. Banner, Barclay A, Berenson R J, Beschorner W E, Bril H, D.G. Sheahan, D.V. Cramer, Dallman M J, Elkins W L, Farnsworth A, Filipovich A H, Kvalheim G, L. Makowka, Lubaroff D M, Martin P J, Monchik G J, Oaks M K, P. Rettinger, Prentice H G, Reisner Y, Rodt H, Slavin R E, T.E. Starzl, Thtschka P J, Tsoi M-S, Van Bekkum D W, Vartdal F, Waldman H, X. Cai   +30 more
core   +1 more source

Effect of Hematopoietic Stem Cell Transplantation Regimen on Tacrolimus Pharmacokinetics

Current Therapeutic Research
: Objectives: Treatment with tacrolimus requires strict control of the whole-blood concentration in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).
Haruno Oku, BS, Saki Yoshida, BS, Takumi Hotta, BS, Hirohito Muroi, BS, Keizo Fukushima, PhD, Kei Irie, PhD, Tatsuya Hirano, BS, Yoshimitsu Shimomura, MD, Takayuki Ishikawa, MD, PhD, Hiroaki Ikesue, PhD, Nobuyuki Muroi, PhD, Tohru Hashida, PhD, Nobuyuki Sugioka, PhD   +12 more
doaj   +1 more source

Engraftment kinetics and graft failure after single umbilical cord blood transplantation using a myeloablative conditioning regimen

Haematologica, 2014
Umbilical cord blood transplant recipients are exposed to an increased risk of graft failure, a complication leading to a higher rate of transplant-related mortality. The decision and timing to offer a second transplant after graft failure is challenging.
A. Ruggeri, M. Labopin, M. Sormani, G. Sanz, J. Sanz, F. Volt, G. Michel, F. Locatelli, C. D. de Heredia, T. O'Brien, W. Arcese, A. Iori, S. Querol, G. Kogler, L. Lecchi, F. Pouthier, F. Garnier, C. Navarrete, E. Baudoux, J. Fernandes, C. Kenzey, M. Eapen, E. Gluckman, V. Rocha, R. Saccardi   +24 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Protective effect of astaxanthin on myocardial injury induced by autologous liver transplantation in rats in conjunction with the Nrf2/HO-1 pathway

Scientific Reports
This study investigated astaxanthin’s cardioprotective effects in rat autologous orthotopic liver transplantation. Male Wistar rats received astaxanthin (500 mg/kg) for two weeks before transplantation, with controls including sham, transplant-only, and ...
Shujun Lu, Yajing Zhang, Yiqi Weng
doaj   +1 more source