Results 111 to 120 of about 795,414 (305)
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
DEVELOPING A CYCLING SUBSYSTEM AS PART OF A SUSTAINABLE MOBILITY STRATEGY: THE CASE OF GDANSK [PDF]
Scientific Journal of Silesian University of Technology. Series Transport, 2016 Modal share is an important component in developing sustainable transport within a city. In recent years, many cities have set modal share targets for balanced and sustainable transport modes: 30% of public transport and 30% of non-motorized (cycling ...
Romanika OKRASZEWSKA +2 more
doaj
Distortions in infrastructure development in urban transport in India: How to remedy it? [PDF]
, 2012 National Urban Transport Policy, the guiding document for urban transport in India, emphasis movement of people and goods and not vehicles. The paper establishes that investment on walking and cycling facilities, and surface rail projects give maximum ...
Manchala, Ravibabu, Vagvala, Phani Sree
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
STATE REGULATION OF CARGO SECURING FOR ROAD TRANSPORT
International Journal of Advanced Studies, 2015 This article examines the legal documents governing the securing of cargo in road transport, provides an overview of international experience in the safety of road transport of goods by means of securing.
Nikolay Anatolievich Atrokhov +1 more
doaj
Images of the Northen Sea Route in the Russian Official Discourse (2008–2024)
Международная аналитикаThis article uses a qualitative and quantitative content analysis of key strategic planning documents and speeches by top government officials from 2008 to 2024 to explore how the image of the Northern Sea Route (NSR) has evolved in contemporary Russian ...
N. S. Lipunov
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Pre-Congestion Notification Encoding Comparison [PDF]
, 2007 DiffServ mechanisms have been developed to support Quality of Service (QoS). However, the level of assurance that can be provided with DiffServ without substantial over-provisioning is limited.
Chan, K., Karagiannis, G.
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source