Results 101 to 110 of about 7,889,263 (337)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Study on the whole lifecycle energy consumption scenarios of expressway

Science and Technology for Energy Transition
This paper constructs a set of energy consumption scenarios for typical expressway construction, operation and maintenance phases, and analyses the energy demand under each scenario.
Peiqiang Cui, Qi Yu, Jie Liu, Ning Mao, Yizheng Wu   +4 more
doaj   +1 more source

Criteria for assessment of welfare impacts within regional planning of transport [PDF]

Regional transport system plans present the wide framework for local transport planning, and are the means of applying the national high-level objectives regionally.
Katja Maarika Estlander, Saara Pekkarinen   +1 more
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Modelling the Impact of Transport Planning Policy Upon Land Use [PDF]

, 1979
In this paper the results from the validation of an integrated land use and transport model are described. The goodness-of-fit for the forecasts are considered not only for the time horizon, but also in terms of the change over time, which is a much more
Mackett, R.L.
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Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Development and Balance Evaluation for Land Use and Transport Interaction Using Node-Place Model and Data Envelopment Analysis

Journal of Advanced Transportation
To meet the evolving demands of land use and transport interaction (LUTI) assessment within China’s national territory spatial planning (NTSP) system, this paper introduces the level of development (LoD) and the level of matching (LoM) evaluation models,
Xiaoyi Ma, Hongjie He, Mingmin Liu, An Jin   +3 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

The principles of public transport network planning: a review of the emerging literature with select examples [PDF]

This paper highlights for urban planners the key strategies and tactics that can be deployed to improve suburban public transport networks. Introduction The governance and management of public transport systems is an essential component of metropolitan
Jago Dodson, John Stone, Matthew Burke, Paul Mees   +3 more
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Irregular no. 42; Aug. 1971 [PDF]

, 1971
In this issue: 1. The Australian Council of Trade Unions (A.C.T.U.) housing? 2. (a) A tame transport reform; (b) Transport traffic tragedy 3.

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