Results 111 to 120 of about 7,889,263 (337)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

The Evolution of Transport Networks [PDF]

open access: yes
Between 1900 and 2000, the length of paved roads in the United States increased from 240 km to 6,400,000 km (Peat 2002, BTS 2002) with virtually 100% of the U.S. population having almost immediate access to paved roadways.
David Levinson
core  

Multi-level tensions in transport policy and planning : bus-rapid transit (BRT) in Indonesia : a dissertation presented in fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) in Planning at Massey University, Palmerston North, New Zealand [PDF]

open access: yes, 2017
International development agencies, supporting climate change sensitive transport policies in Low-Income Asian (LIA) cities, promote Bus Rapid Transit (BRT). However, these policies create tensions at the local level.
Wijaya, Suryani Eka
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Linking Smartphone GPS Data with Transport Planning: A Framework of Data Aggregation and Anonymization for a Journey Planning App [PDF]

open access: yes, 2017
With the proliferation of GPS tracking data provided by smartphone apps, it is desirable to develop a data processing and anonymizing framework to transform raw GPS data into a suitable format for transport planning models. The paper aims to describe the
McArthur, David Philip, Wang, Yang
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Mode use in long-distance travel

open access: yesJournal of Transport and Land Use, 2015
This paper focuses on mode use in long-distance travel. Long-distance travel is responsible for more than 50 percent of climate impact. Nevertheless, it is usually excluded from analyses that examine travel behavior. Whereas studies on daily travel prove
Alexander Reichert, Christian Holz-Rau
doaj   +1 more source

Models and applications of Optimal Transport in Economics, Traffic and Urban Planning

open access: yes, 2009
Some optimization or equilibrium problems involving somehow the concept of optimal transport are presented in these notes, mainly devoted to applications to economic and game theory settings.
Santambrogio, Filippo
core   +1 more source

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