Results 81 to 90 of about 7,889,263 (337)

A new class of costs for optimal transport planning

European journal of applied mathematics, 2018
We study a class of optimal transport planning problems where the reference cost involves a non-linear function G(x, p) representing the transport cost between the Dirac measure δx and a target probability p.
J. Alibert, Guy Bouchitté, T. Champion
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Windowed Transportation Planning Model [PDF]

Transportation Research Record: Journal of the Transportation Research Board, 1997
A transportation planning model that integrates regional and local-area forecasting approaches is developed and applied. Although regional models have the scope to model the interaction of demand and congestion, they lack spatial detail. Local-area analysis typically does not consider the feedback between new project loadings and existing levels of ...
Levinson, David M, Huang, Yuanlin
openaire   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Modelling requirements for local transport plans in the UK [PDF]

, 2006
The aim of the paper is to provide a number of recommendations for use of transport and land use planning models in the formulation of local transport plans. It is based on a study of Local Transport Plans (LTPs) in England.
May, A.D., Shepherd, S.P., Timms, P.M.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effects of Individual and Built Environmental Features on Commuting Mode Shifts before and after the COVID-19 Outbreak in Guangzhou, China

Journal of Advanced Transportation, 2023
The novel coronavirus disease (COVID-19) pandemic has had a significant impact on transportation. Understanding how the epidemic in China has affected people’s travel mode choices can help city managers analyze the travel mode of different populations in
Yuyue Gao, Jian Chen, Keke Ji, Keliang Liu, Haizhou Liu, Lankai Wang   +5 more
doaj   +1 more source

The role of city geometry in determining the utility of a small urban light rail/tram system

, 2020
In this work, we show the importance of considering a city's shape, as much as its population density figures, in urban transport planning. We consider in particular cities that are circular (the most common shape) compared to those that are rectangular:
Gettrick, Michael Mc
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Comparing GPS and cell-based mobile phone data to identify activity participation during the COVID-19 pandemic

EPJ Data Science
This study conducts a detailed analysis of population mobility during the COVID-19 pandemic, utilizing a unique approach that contrasts two types of mobile phone data: GPS-based and cell-based.
Sebastian A. Mueller, Sydney Paltra, Jakob Rehmann, Ricardo Ewert, Kai Nagel   +4 more
doaj   +1 more source