Results 71 to 80 of about 66,707 (255)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Transport and Older People: Integrating Transport Planning Tools with User Needs

, 2007
This study was funded through a pump-priming grant from the Strategic Promotion of Ageing Research Capacity (SPARC) programme. The purpose of the project was to bring together transport and public health research in order to demonstrate how the ...
Marsden, G, Jopson, A, Cattan, M, Woodward, J   +3 more
core  

Planning for Transport in the Wake of Stern and Eddington [PDF]

, 2009
Docherty I. and Mackie P. Planning for transport in the wake of Stern and Eddington, Regional Studies. The recent Stern and Eddington Reports for the UK Treasury emphasize the significance of the linkages between transport, land use, the environment, and
Peter Mackie, Iain Docherty, Mackie, Peter, Docherty, Iain   +3 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Multimodal Freight Transport Planning: A Toolbox Supporting Stakeholders’ Collaboration

, 2019
This paper aims to analyse the planning of chemical transports’ shift from road to the more complex multimodal freight transport, and presents a toolbox developed to support the stakeholders in the process.
Cichosz, Marzenna; SGH Warsaw School of Economics, Department of Transport
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Transport planning education in urban planning schools in Australia

, 2013
In the next four decades, seventy per cent of the world's population will become urban, demanding improved mobility and better accessibility. Yet current transport planning practice at both international and domestic level has not been able to keep pace ...
Burke, MI, Mateo-Babiano, I
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Modeling Uncertainties for Automated and Connected Vehicles in Mixed Traffic

Journal of Advanced Transportation
The advent of automated vehicles (AVs) and connected automated vehicles (CAVs) creates significant uncertainties in infrastructure planning due to many unknowns, such as performance variability and user adaptation. As technologies are still emerging with
Yuchao Sun, Liam Cummins, Yan Ji, Thomas Stemler, Nicholas Pritchard   +4 more
doaj   +1 more source