Results 61 to 70 of about 66,707 (255)

Dynamic Multi-Period Maritime Accident Susceptibility Assessment Based on AIS Data and Random Forest Model

Journal of Marine Science and Engineering, 2023
Maritime accidents, such as ship collisions and oil spills, directly affect maritime transportation, pollute the water environment, and indirectly threaten life and property safety.
Weihua Zhu, Shoudong Wang, Shengli Liu, Libo Yang, Xinrui Zheng, Bohao Li, Lixiao Zhang   +6 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

How to Apply Gender Equality Goals in Transport and Infrastructure Planning

, 2019
Working systematically on gender mainstreaming in transport infrastructure entails implementing a gender perspective in all stages of decision-making, planning and execution.
Charlotta Faith-Ell, Lena Levin, Levin, Lena,, Faith-Ell, Charlotta,   +3 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Comparing GPS and cell-based mobile phone data to identify activity participation during the COVID-19 pandemic

EPJ Data Science
This study conducts a detailed analysis of population mobility during the COVID-19 pandemic, utilizing a unique approach that contrasts two types of mobile phone data: GPS-based and cell-based.
Sebastian A. Mueller, Sydney Paltra, Jakob Rehmann, Ricardo Ewert, Kai Nagel   +4 more
doaj   +1 more source

Local-Regional Perspective in Mega Transport Infrastructure Planning

, 2015
This book is based on the research conducted in the context of Poly5, a European project promoted under the Alpine Space programme 2011–2014. The project attempts to critically deal with current approaches to the planning of European Corridors ...
FABBRO, Sandro, Sandro Fabbro
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Public transport planning adaption under the COVID-19 pandemic crisis: literature review of research needs and directions [PDF]

, 2020
The COVID-19 pandemic crisis has greatly impacted public transport ridership and service provision across the world. As many countries start to navigate their return to normality, new public transport planning requirements are devised.
Cats, O., Gkiotsalitis, Konstantinos (author), Cats, Oded, Cats, O. (author), Gkiotsalitis, Konstantinos   +4 more
core   +1 more source