Results 51 to 60 of about 66,707 (255)

Application of fuzzy analytical hierarchy process to develop walkability index: a case study of Dwarka sub city, New Delhi, India

Urban, Planning and Transport Research, 2023
Walkability is an important aspect of the built environment, influencing the degree and intensity of walking. Very little research effort has been made in cities of developing countries like India to incorporate the user’s perspective in evolving ...
Sairam Dasari, Sanjay Gupta
doaj   +1 more source

The principles of public transport network planning: a review of the emerging literature with select examples [PDF]

, 2011
This paper highlights for urban planners the key strategies and tactics that can be deployed to improve suburban public transport networks. Introduction The governance and management of public transport systems is an essential component of metropolitan
John Stone, Matthew Burke, Jago Dodson, Paul Mees   +3 more
core  

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Investigating Influence Factors on Traffic Safety Based on a Hybrid Approach: Taking Pedestrians as an Example

Sensors
Road traffic safety is an essential component of public safety and a globally significant issue. Pedestrians, as crucial participants in traffic activities, have always been a primary focus with regard to traffic safety.
Yue Li, Yuanyuan Shi, Huiyuan Xiong, Feng Jian, Xinxin Yu, Shuo Sun, Yunlong Meng   +6 more
doaj   +1 more source

A DEM Optimization Algorithm for Enhancing Efficiency in Highway Design [PDF]

E3S Web of Conferences
To address the engineering challenges of Digital Elevation Model (DEM) data storage redundancy, low elevation query efficiency, and discontinuous elevation between adjacent grids in highway design, this paper proposes a DEM hierarchical tile caching and ...
Xie Youshun, Zhou Yi, Yan Wen, Li Youbai, Li Wei   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Author Correction: Empirical dynamics of railway delay propagation identified during the large-scale Rastatt disruption

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Beda Büchel, Thomas Spanninger, Francesco Corman   +2 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Gaussian Process Regression for Tail Vehicle Departure Time Prediction at Signalized Intersections Using UAV Trajectory Data

Sensors
Extensive research has been conducted on vehicle queuing and dissipation near signalized intersections. However, existing prediction methods for vehicle departure time primarily rely on assumptions of steady-state homogeneous traffic flow, utilizing ...
Kaiming Lu, Zhe Liu, Runsheng Zhang, Qingyang Xia, Ruoxuan Wang   +4 more
doaj   +1 more source