Results 51 to 60 of about 4,594,618 (280)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Scientific Reports, 2021 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Beda Büchel +2 more
doaj +1 more source
, 2019 Transport and mobility are integrated everyday activities in people’s lives. Transport research and planning has been characterized by utilitarian, rationalistic and quantitative epistemologies.
Tanja Joelsson +3 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
SensorsExtensive research has been conducted on vehicle queuing and dissipation near signalized intersections. However, existing prediction methods for vehicle departure time primarily rely on assumptions of steady-state homogeneous traffic flow, utilizing ...
Kaiming Lu +4 more
doaj +1 more source
Improving pedestrian access way planning using designing out crime [PDF]
, 2008 Pedestrian Access Ways (PAWs) have presented a significant and unresolved challenge to transport planners in local and State government. The result has been piecemeal local government and State government approaches that have frequently resulted in ...
Love, Terence, Cozens, Paul
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
'Moving to Access' in Transport Planning: Identifying Barriers, Designing Strategies [PDF]
, 2017 Accessibility is a well-established concept in planning research. It measures the ease of reaching destinations or activities, or the potential for interaction (Hansen, 1959). In very general terms, accessibility can be defined as the level of ability to
Ferreira, A., Papa, E.
core