Results 31 to 40 of about 5,985 (254)

Is Scientific Knowledge Useful for Policy Analysis? A Peculiar Theorem Says: No

Journal of Causal Inference, 2014
Conventional wisdom dictates that the more we know about a problem domain the easier it is to predict the effects of policies in that domain. Strangely, this wisdom is not sanctioned by formal analysis, when the notions of “knowledge” and “policy” are ...
Pearl Judea
doaj   +1 more source

Cross-site transportability of an explainable artificial intelligence model for acute kidney injury prediction

Nature Communications, 2020
Artificial intelligence (AI) has demonstrated promise in predicting acutekidney injury (AKI), however, clinical adoption of these models requires interpretability and transportability across sites.
Xing Song, Alan S. L. Yu, John A. Kellum, Lemuel R. Waitman, Michael E. Matheny, Steven Q. Simpson, Yong Hu, Mei Liu   +7 more
doaj   +1 more source

Transportability of Conclusions From Confined Field Trials: A Case Study Using the Virus Resistant Transgenic Bean Developed in Brazil

Frontiers in Bioengineering and Biotechnology, 2020
The conceptual framework for Data Transportability, builds on the premise that well-designed studies conducted for the environmental and food/feed risk assessment of transgenic crops may be transportable across geographies.
Facundo Vesprini, Facundo Vesprini, Andrés Ignacio Maggi, Andrés Ignacio Maggi, Magdalena López Olaciregui, Magdalena López Olaciregui, Natalia Andrea Módena, Natalia Andrea Módena   +7 more
doaj   +1 more source

International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality

npj Digital Medicine, 2022
Given the growing number of prediction algorithms developed to predict COVID-19 mortality, we evaluated the transportability of a mortality prediction algorithm using a multi-national network of healthcare systems.
Griffin M. Weber, Chuan Hong, Zongqi Xia, Nathan P. Palmer, Paul Avillach, Sehi L’Yi, Mark S. Keller, Shawn N. Murphy, Alba Gutiérrez-Sacristán, Clara-Lea Bonzel, Arnaud Serret-Larmande, Antoine Neuraz, Gilbert S. Omenn, Shyam Visweswaran, Jeffrey G. Klann, Andrew M. South, Ne Hooi Will Loh, Mario Cannataro, Brett K. Beaulieu-Jones, Riccardo Bellazzi, Giuseppe Agapito, Mario Alessiani, Bruce J. Aronow, Douglas S. Bell, Vincent Benoit, Florence T. Bourgeois, Luca Chiovato, Kelly Cho, Arianna Dagliati, Scott L. DuVall, Noelia García Barrio, David A. Hanauer, Yuk-Lam Ho, John H. Holmes, Richard W. Issitt, Molei Liu, Yuan Luo, Kristine E. Lynch, Sarah E. Maidlow, Alberto Malovini, Kenneth D. Mandl, Chengsheng Mao, Michael E. Matheny, Jason H. Moore, Jeffrey S. Morris, Michele Morris, Danielle L. Mowery, Kee Yuan Ngiam, Lav P. Patel, Miguel Pedrera-Jimenez, Rachel B. Ramoni, Emily R. Schriver, Petra Schubert, Pablo Serrano Balazote, Anastasia Spiridou, Amelia L. M. Tan, Byorn W. L. Tan, Valentina Tibollo, Carlo Torti, Enrico M. Trecarichi, Xuan Wang, The Consortium for Clinical Characterization of COVID-19 by EHR (4CE), Isaac S. Kohane, Tianxi Cai, Gabriel A. Brat   +64 more
doaj   +1 more source

Transport and transporters in the endoplasmic reticulum

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
Enzyme activities localized in the luminal compartment of the endoplasmic reticulum are integrated into the cellular metabolism by transmembrane fluxes of their substrates, products and/or cofactors. Most compounds involved are bulky, polar or even charged; hence, they cannot be expected to diffuse through lipid bilayers.
CSALA, M., MARCOLONGO, P., LIZAK, B., SENESI, S., MARGITTAI, E., FULCERI, R., MAGYAR, J. E., BENEDETTI, A., BANHEGYI, G.   +8 more
openaire   +5 more sources

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Feasibility of sliding base isolation for rubble stone masonry buildings in the Himalayan Mountain range

Frontiers in Built Environment
This paper studied the feasibility of a sliding base isolation layer to be used in rubble stone masonry buildings in rural areas in the Himalayan Mountain range to provide robust protection to important building like schools against strong earthquakes ...
Yusuke Suzuki, Mayako Tada, Ryuta Enokida, Jiro Takagi, Yoshikazu Araki, Sanjay Pareek, Sanghun Lee, Kohju Ikago, Jia Guo, Kshitij C. Shrestha, Iori Fukuda, Takeshi Masui   +11 more
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

Generalizing Experimental Findings

Journal of Causal Inference, 2015
This note examines one of the most crucial questions in causal inference: “How generalizable are randomized clinical trials?” The question has received a formal treatment recently, using a non-parametric setting, and has led to a simple and general ...
Pearl Judea
doaj   +1 more source