Results 71 to 80 of about 2,757,039 (300)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

open access: yesMolecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan   +8 more
wiley   +1 more source

Other title: Regarding the Department of Transportation's Fiscal Year Two Thousand Eight Budget Other title: Kansas Department of Transportation's FY 2008 Budget Other title: KDOT's FY 2008 Budget Other title: Fiscal Year 2008 Budget Other title: FY 2008 Budget

open access: yes, 2007
application/pdf "February 8, 2007." Presentation to the Kansas Legislature, Senate Ways and Means Subcommittee on Kansas Department of Transportation, by staff of the Kansas Department of Transportation.Presentation showing the project costs of
Kansas. Department of Transportation.
core   +1 more source

Intelligent Optimization Scheduling Strategy for Energy Consumption Reduction for Equipment in Open-Pit Mines Based on Enhanced Genetic Algorithm

open access: yesEnergies
To achieve a rational allocation of real-time operational equipment, such as excavators and dump trucks, in open-pit mines, and thereby enhance truck–shovel coordination, this paper addresses the challenges posed by unreasonable on-site scheduling, which
Fudong Li   +3 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

open access: yesMolecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara   +10 more
wiley   +1 more source

Influence of costs on the optimization of transport routes (case study) - Passenger transportation company from Zagreb

open access: yesEkonomski Vjesnik, 2018
Small and medium-sized road transport companies located in Croatia are faced with strong competition on the transport and logistics market. The problem of cost management in road transport enterprises is one of the most crucial ones for their efficient ...
Marinko Jurčević   +2 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Integral criteria for transportation cost inequalities

open access: yesElectronic Communications in Probability, 2006
In this paper, we provide a characterization of a large class of transportation-cost inequalities in terms of exponential integrability of the cost function under the reference probability measure. Our results completely extend the previous works by Djellout, Guilin and Wu and Bolley and Villani.
openaire   +5 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

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