Results 51 to 60 of about 2,757,039 (300)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Transportation Economic Trends 2017 [PDF]
The report has eight chapters: - Chapter 1 introduces the Transportation Services Index, a monthly summary of freight and passenger movement. - Chapter 2 explains what transportation contributes to the American economy.
Brumbaugh, Stephen +3 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Investing in transportation to keep Texas economically competitive [PDF]
This current report, It's About Time: Investing in Transportation to Keep TexasEconomically Competitive, updates the February 2009 report by providingan enhanced analysis of the current state of the Texas transportation system,determining the household ...
Texas. Transportation Commission
core
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
The gravity hypothesis and transportation cost minimization [PDF]
Regional and Urban Economics, 1972 Abstract The Hitchcock-Koopmans transportation is linked to the gravity ‘model’ of regional analysis with the aid of two new analytical results. Eighty transportation problems are generated by Monte Carlo methods and solved by linear programming. The transportation cost minimizing flows are compared with the flows generated by gravity methods in ...
openaire +3 more sources
Finding Transportation Statistics
National Transportation Library (NTL) guide provides website links to resources related to the transportation industry. Includes statistics resources for general, multimodal, economic, highway, transit/rail, aviation and maritime ...
United States. Department of Transportation. National Transportation Library
core +1 more source
Paratransit, Inc.: Special Transportation Service in Sacramento [PDF]
DOT-TSC-1408Paratransit, Inc., a nonprofit corporation created in July, 1978, offers special transportation for handicapped and elderly persons in the Sacramento area.
Flynn, Sydwell +2 more
core +1 more source