Results 61 to 70 of about 2,757,039 (300)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Transportation Cost Assessment by Means of a Monte Carlo Simulation in a Transshipment Model

Promet (Zagreb), 2008
The task of transport management is to organize the transportof goods from a number of sources to a number of destinationswith minimum total costs.
Gordana Dukić, Darko Dukić, Ivana Alerić   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Other title: Kansas Department of Transportation Agency Overview Other title: Agency Overview Other title: Title from Kansas Department of Transportation website: Presentation on Transportation Status in Kansas

, 2010
application/pdf Title supplied by cataloger from file name. "January 20, 2010." Presentation to the Kansas Legislature, House Committee on Transportation, by staff of the Kansas Department of Transportation.
Kansas. Department of Transportation.
core   +1 more source

FORMATION AND WAYS TO OPTIMIZE TRANSPORTATION COSTS OF A MANUFACTURING ENTERPRISE

International Journal of Advanced Studies
The article examines the patterns of changes in transport costs of a company providing transport and logistics services. The transport company "M" was chosen as the object of the study.
Tatyana V. Konovalova, Alexander N. Dombrovsky, Sofiya L. Nadiryan, Sofiya V. Kotsurba   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Application of a discrete approach to designing the transport component of municipal solid waste logistics

Вестник СибАДИ
Introduction. The growth of the urban area has led to the need to transfer landfills for the disposal of solid municipal (household) waste (MSW) to more remote locations on new sites. Representations and approaches to cargo transportation planning are an
E. E. Vitvitsky, E. S. Galaktionova, N. I. Yuryeva   +2 more
doaj   +1 more source

ANALYSIS OF THEORETICAL APPROACHES TO ESTIMATION OF ECONOMIC VALUATION OF TRAVEL TIME VARIABILITY AND THE VALUE OF TRAVEL TIME SAVINGS OF URBAN PASSENGER TRANSPORT

Вестник университета, 2018
The overview of some theoretical approaches to the mechanism of economic valuation of travel time variability and the value of travel time savings of urban passenger transport is provided.
V. Donchenko, R. Filippova
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source