Results 41 to 50 of about 962,118 (368)

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]

, 2017
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M., Alzahrani, Khalid J.H., Barrett, Michael P., Creek, Darren J., De Koning, Harry P., Eze, Anthonius A., Looi, Wan Limm, Tagoe, Daniel N.A.   +7 more
core   +2 more sources

Melatonin Improves Laying Performance by Enhancing Intestinal Amino Acids Transport in Hens

Frontiers in Endocrinology, 2018
The high concentration of melatonin (MEL) in the intestinal mucosa suggests that it has a special physiological function in intestine. In hens, previous studies have shown that MEL treatment promoted egg-laying performance.
Lijuan Liu, Siyu Zhang, Jiayang Bao, Xiaowen He, Danni Tong, Cong Chen, Qingxiang Ying, Qing Zhang, Caiqiao Zhang, Jian Li   +9 more
doaj   +1 more source

Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter [PDF]

, 2008
Multiple pathways link expression of PTR2, the transporter of di- and tripeptides in the yeast Saccharomyces cerevisiae, to the availability and quality of nitrogen sources.
Abdel-Sater, Abdel-Sater, Alagramam, Andréasson, Andréasson, Bachmair, Bernard, Boban, Boles, Byrd, Cai, Cai, Ditzel, Du, Fosberg, Frommer, Ghislain, Godard, Graciet, Holsbeeks, Homann, Hou, Hu, Hu, Hu, Inobe, Island, Johnson, Jorgensen, Klasson, Kwon, Kwon, Laney, Lee, Liu, Malavé, Mogk, Nielsen, Rao, Roosen, Sasaki, Schneider, Sikorski, Spielewoy, Suzuki, Tasaki, Tasaki, Tasaki, Turner, Turner, Varshavsky, Varshavsky, Varshavsky, Wiles, Wu, Xia, Xiao, Xie, Zenker   +58 more
core   +3 more sources

Golgi Metal Ion Homeostasis in Human Health and Diseases

Cells, 2022
The Golgi apparatus is a membrane organelle located in the center of the protein processing and trafficking pathway. It consists of sub-compartments with distinct biochemical compositions and functions.
Jie Li, Yanzhuang Wang
doaj   +1 more source

Molecular Characteristics of the Conserved Aspergillus nidulans Transcription Factor Mac1 and Its Functions in Response to Copper Starvation

mSphere, 2019
Copper (Cu) is an essential trace element in all organisms, and Cu acquisition during periods of starvation is important for cell survival and proliferation.
Zhendong Cai, Wenlong Du, Lianhong Liu, Daodong Pan, Ling Lu   +4 more
doaj   +1 more source

Aging-Related Changes in Expression and Function of Glutamate Transporters in Rat Spinal Cord Astrocytes

Neuroglia, 2023
Astrocytes make up the predominant cell population among glial cells in the mammalian brain, and they play a vital role in ensuring its optimal functioning.
Shiksha Sharan, Bhanu Prakash Tewari, Preeti G. Joshi   +2 more
doaj   +1 more source

Multiple Targeting Approaches on Histamine H3 Receptor Antagonists

Frontiers in Neuroscience, 2016
With the very recent market approval of pitolisant (Wakix®), the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been
Mohammad eKhanfar, Anna eAffini, Kiril eLutsenko, Katarina eNikolic, Stefania eButini, Holger eStark   +5 more
doaj   +1 more source

Cadmium Accumulation in Cereal Crops and Tobacco: A Review

Agronomy, 2022
Cadmium (Cd) is a toxic heavy metal with no known biological function in plants and one of the most toxic substances released into the environment. Crops, such as rice, maize, wheat and tobacco are the major sources of Cd for humans. Cd toxicity inhibits
Shineng Mei, Kaina Lin, Darron V. Williams, Yang Liu, Huaxin Dai, Fangbin Cao   +5 more
doaj   +1 more source

Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality [PDF]

, 2010
A Plasmodium falciparum hexose transporter (PfHT) has previously been shown to be a facilitative glucose and fructose transporter. Its expression in Xenopus laevis oocytes and the use of a glucose analogue inhibitor permitted chemical validation of PfHT ...
Doerig, C, Krishna, S, Morin, C, Reininger, L, Slavic, K, Straschil, U, Tewari, R   +6 more
core   +2 more sources

Geographic variation in walking activity in the red flour beetle Tribolium castaneum

Population Ecology, EarlyView.
This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley   +1 more source