Results 41 to 50 of about 981,318 (341)

Awareness of Genetic Polymorphism in Drug Metabolizing Enzymes and Transporters May Promote Personalized Type 2 Diabetes Management [Response to Letter]

Diabetes, Metabolic Syndrome and Obesity, 2022
David M Williams,1 Jeffrey W Stephens1,2 1Department of Diabetes and Endocrinology, Morriston Hospital, Swansea Bay University Health Board, Swansea, SA6 8NL, UK; 2Diabetes Research Group, Swansea University Medical School, Swansea University, Swansea ...
Williams DM, Stephens JW
doaj  

Proton Motive Force-Dependent Hoechst 33342 Transport by the ABC Transporter LmrA of Lactococcus lactis [PDF]

, 2005
The fluorescent compound Hoechst 33342 is a substrate for many multidrug resistance (MDR) transporters and is widely used to characterize their transport activity.
Abbreviations ABC, Chen M., Doerrler W. T., Ecker G. F., Gajic O., Haugland R. P., Higuchi R., Ketchum C. J., Kuipers O. P., Lalande M. E., Lanzetta P. A., Lewinson O., Linnett P. E., Lubelski J., Lubelski J., Margolles A., Mazurkiewicz P., Orelle C., Paternostre M. T., Poelarends G. J., Putman M., Sakamoto K., Sambrook J., Shapiro A. B., Shapiro A. B., Shapiro A. B., Shapiro A. B., Sharma S., Steinfels E., Urbatsch I. L., van Veen H. W., van Veen H. W., van Veen H. W., Venter H., Viitanen P., Yu J. L.   +35 more
core   +2 more sources

Cell-Mediated and Peptide-Based Delivery Systems: Emerging Frontiers in Targeted Therapeutics

Pharmaceutics
Background/Objectives: Cell-mediated and peptide-assisted delivery systems have emerged as powerful platforms at the intersection of chemistry, nanotechnology, and molecular medicine.
Eszter Erdei, Ruth Deme, Balázs Balogh, István M. Mándity   +3 more
doaj   +1 more source

Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons

eLife, 2023
Understanding the function of glutamate transporters has broad implications for explaining how neurons integrate information and relay it through complex neuronal circuits.
Maurice A Petroccione, Lianna Y D'Brant, Nurat Affinnih, Patrick H Wehrle, Gabrielle C Todd, Shergil Zahid, Haley E Chesbro, Ian L Tschang, Annalisa Scimemi   +8 more
doaj   +1 more source

Identification of transporter genes from the fungal endophyte Neotyphodium lolii : this thesis is presented in partial fulfilment of the requirements for the degree of Master of Science (MSc) in Plant Biology at Massey University, Palmerston North, New Zealand / [PDF]

, 2006
Neotyphodium lolii is an endophytic fungus that lives in the pasture grass, Lolium perenne. They share a mutualistic symbiotic relationship. N. lolii lives out its life cycle within the plant and produces secondary metabolites, including alkaloids ...
Knox, Deborah Sian
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

An international questionnaire highlights and supports the case for including girls in Creatine Transporter Deficiency research

Frontiers in Neuroscience
Over the last 15 years, significant progress has been made for Creatine Transporter Deficiency (CTD) patients, with increased awareness and visibility, better diagnosis, and improved care.
Carole Chehowah, Carole Chehowah, Audrey Mittelman, Vincent des Portes   +3 more
doaj   +1 more source

The solute transport and binding profile of a novel nucleobase cation symporter 2 from the honeybee pathogen Paenibacillus larvae

FEBS Open Bio, 2018
Here, we report that a novel nucleobase cation symporter 2 encoded in the genome of the honeybee bacterial pathogen Paenibacillus larvae reveals high levels of amino acid sequence similarity to the Escherichia coli and Bacillus subtilis uric acid and ...
Amanda J. Stoffer‐Bittner, Candace R. Alexander, Douglas W. Dingman, George S. Mourad, Neil P. Schultes   +4 more
doaj   +1 more source

Nephron‐Specific Disruption of Nitric Oxide Synthase 3 Causes Hypertension and Impaired Salt Excretion

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background In vitro studies suggest that nephron nitric oxide synthase 3 (NOS3) modulates tubule Na+ transport. Methods and Results To assess nephron NOS3 relevance in vivo, knockout (KO) mice with doxycycline‐inducible nephron‐wide deletion of NOS3 were
Yang Gao, Deborah Stuart, Takamune Takahishi, Donald E. Kohan   +3 more
doaj   +1 more source

Roles for the Uptake\u3csub\u3e2\u3c/sub\u3e Transporter OCT3 in Regulation of Dopaminergic Neurotransmission and Behavior [PDF]

, 2019
Transporter-mediated uptake determines the peak concentration, duration, and physical spread of released monoamines. Most studies of monoamine clearance focus on the presynaptic uptake1 transporters SERT, NET and DAT.
Gasser, Paul J.
core   +1 more source