Results 71 to 80 of about 516,723 (293)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Amino Acid Transporters in Plant Cells: A Brief Review

open access: yesPlants, 2020
Amino acids are not only a nitrogen source that can be directly absorbed by plants, but also the major transport form of organic nitrogen in plants. A large number of amino acid transporters have been identified in different plant species.
Guangzhe Yang   +3 more
doaj   +1 more source

Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota [PDF]

open access: yes, 2014
Dietary intake of L-carnitine can promote cardiovascular diseases in humans through microbial production of trimethylamine (TMA) and its subsequent oxidation to trimethylamine N-oxide (TMAO) by hepatic flavin-containing monooxygenases.
Bugg, Tim   +6 more
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Effect of energy sources and levels on caecal microbial population, jejunal morphology, gene expression of jejunal transporters (sglt1, fabp) and performance of broilers under heat stress [PDF]

open access: yesKafkas Universitesi Veteriner Fakültesi Dergisi, 2017
The present study was conducted to evaluate the effects of energy sources and levels on microbial population, jejunal morphology, gene expression of glucose transporter (SGLT1), fatty acid binding protein (FABP) and performance in broilers under heat ...
GHAHREMANI A   +4 more
doaj   +1 more source

Growth and Overall Health of Patients with SLC13A5 Citrate Transporter Disorder

open access: yesMetabolites, 2021
We were interested in elucidating the non-neurologic health of patients with autosomal recessive SLC13A5 Citrate Transporter (NaCT) Disorder. Multiple variants have been reported that cause a loss of transporter activity, resulting in significant ...
Tanya L. Brown   +2 more
doaj   +1 more source

NRT2.5 a putative sodium dependent high affinity nitrate trasnporter of zostera marina l. [PDF]

open access: yes, 2018
Seagrasses are the only group of vascular plants that recolonized the marine environment, possibly the most severe habitat shift ever accomplished by flowering plants.
Botella-Mesa, Miguel Angel   +3 more
core  

A Cl- cotransporter selective for NH4+ over K+ in glial cells of bee retina [PDF]

open access: yes, 2000
There appears to be a flux of ammonium (NH4+/NH3) from neurons to glial cells in most nervous tissues. In bee retinal glial cells, NH4+/NH3 uptake is at least partly by chloride-dependant transport of the ionic form NH4+.
Abramowitz   +56 more
core   +4 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Effects of Sodium and Amino Acid Substrate Availability upon the Expression and Stability of the SNAT2 (SLC38A2) Amino Acid Transporter

open access: yesFrontiers in Pharmacology, 2018
The SNAT2 (SLC38A2) System A amino acid transporter mediates Na+-coupled cellular uptake of small neutral α-amino acids (AAs) and is extensively regulated in response to humoral and nutritional cues.
Thorsten M. Hoffmann   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy