Results 201 to 210 of about 2,250,508 (337)

CD103+ T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis

open access: yesAdvanced Science, EarlyView.
This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu   +7 more
wiley   +1 more source

A Two‐Component Pseudo‐Icosahedral Protein Nanocompartment with Variable Shell Composition and Irregular Tiling

open access: yesAdvanced Science, EarlyView.
The structure and assembly principles of a two‐component encapsulin nanocompartment shell are reported. The two‐component protein compartment self‐assembles from two distinct HK97‐fold shell proteins into a pseudo‐icosahedral protein shell with variable composition and irregular tiling.
Cassandra A. Dutcher   +2 more
wiley   +1 more source

Transposable element activity captures human pluripotent cell states. [PDF]

open access: yesEMBO Rep
Levin-Ferreyra F   +6 more
europepmc   +1 more source

Unraveling Tissue‐Specific Fatty Acid Biosynthesis and Inter‐Tissue Crosstalk in Mice through Stable‐Isotope Tracing Metabolomics

open access: yesAdvanced Science, EarlyView.
Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter‐tissue communications of fatty acids between the liver and other tissues is developed. Moreover, the approach is extended to aging condition and a system‐wide decline of fatty acid synthesis in peripheral ...
Beizi Xing   +4 more
wiley   +1 more source

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

open access: yesAdvanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang   +11 more
wiley   +1 more source

Evolutionary Dynamics of Transposable Element Activity and Regulation in the Apennine Yellow-Bellied Toad (Bombina pachypus). [PDF]

open access: yesGenome Biol Evol
Ancona L   +7 more
europepmc   +1 more source

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