Results 61 to 70 of about 100,531 (319)

Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression.

PLoS ONE, 2021
Alternative splicing of the gene MAPT produces several isoforms of tau protein. Overexpression of these isoforms is characteristic of tauopathies, which are currently untreatable neurodegenerative diseases.
Jennifer Grundman, Brian Spencer, Floyd Sarsoza, Robert A Rissman   +3 more
doaj   +1 more source

TranspoGene and microTranspoGene: transposed elements influence on the transcriptome of seven vertebrates and invertebrates [PDF]

, 2008
Transposed elements (TEs) are mobile genetic sequences. During the evolution of eukaryotes TEs were inserted into active protein-coding genes, affecting gene structure, expression and splicing patterns, and protein sequences.
Asaf Levy, Biemont, Borchert, Callinan, Clark, Consortium, Dagan, Deininger, Deininger, Gasteiger, Giardine, Gil Ast, Griffiths-Jones, Han, Hedges, Houwing, Johnson, Jordan, Jurka, Karolchik, Kent, Kim, Kim, Kuhn, Lander, Lev-Maor, Lippman, Lorenc, Makalowski, Martignetti, McKusick, Morgan, Noa Sela, Pasyukova, Piriyapongsa, Pruitt, Sayah, Sela, Smalheiser, Smalheiser, Sorek, Sorek, Thornburg, Waterston   +43 more
core   +3 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Transposon insertion profiling by sequencing (TIPseq) for mapping LINE-1 insertions in the human genome

Mobile DNA, 2019
Background Transposable elements make up a significant portion of the human genome. Accurately locating these mobile DNAs is vital to understand their role as a source of structural variation and somatic mutation. To this end, laboratories have developed
Jared P. Steranka, Zuojian Tang, Mark Grivainis, Cheng Ran Lisa Huang, Lindsay M. Payer, Fernanda O. R. Rego, Thiago Luiz Araujo Miller, Pedro A. F. Galante, Sitharam Ramaswami, Adriana Heguy, David Fenyö, Jef D. Boeke, Kathleen H. Burns   +12 more
doaj   +1 more source

Transposable element annotation in non‐model species: The benefits of species‐specific repeat libraries using semi‐automated EDTA and DeepTE de novo pipelines [PDF]

, 2021
Ellen A. Bell, Christopher L. Butler, Cláudio Oliveira, Sarah Marburger, Levi Yant, Martin I. Taylor   +5 more
openalex   +1 more source

Integrating transposable elements in the 3D genome [PDF]

, 2019
Chromosome organisation is increasingly recognised as an essential component of genome regulation, cell fate and cell health. Within the realm of transposable elements (TEs) however, the spatial information of how genomes are folded is still only rarely ...
A Bousios, A Bridier-Nahmias, A Buckle, A Ciuffi, A Cournac, A Le Rouzic, AE Hafner, AL Sanborn, AN Boettiger, AP Wolffe, ARW Schroder, B Bonev, B Charlesworth, B Marini, C Vara, C Xue, CA Brackley, CA Brackley, CA Brackley, CA Brackley, CM Caragine, CP Brangwynne, CP Brangwynne, D Jost, D Michieletto, D Michieletto, D Michieletto, D Michieletto, D Pruss, D Pruss, D Schmidt, DG Schatz, DH Sanchez, DJ Winter, E Lieberman-Aiden, E Orlandini, E Serrao, EB Chuong, EP Nora, F Benedetti, F Erdel, G Fudenberg, G Kunarso, GP Wang, H Zayed, HE Lee, Horng D. Ou, I Solovei, IM Flyamer, J Dekker, J Kind, J Nuebler, J Wang, JH Sun, JM Santos-Pereira, Jonathan D Halverson, JR Dixon, JS Lucas, K Roessler, KD Taganov, KG Alavattam, KL Chan, L Hilbert, L Lu, LA Mirny, Lindsay M. Payer, M Benleulmi, M Chiang, M Ciubotaru, M Di Pierro, M Eltsov, M Kvaratskhelia, M Naughtin, M Pasi, MN Choudhary, N Gilbert, N Khanna, P Dong, PJ Flory, PM Pryciak, PS Schnable, R Collepardo-Guevara, R Craigie, R Raviram, R Schrijvers, R Stadhouders, R Stadhouders, R-s Nozawa, S Bianco, S Cheung, S Grob, S Zhou, SSP Rao, SSP Rao, T Cremer, T Nagano, T Sultana, T Wicker, TH Eickbush, V Aidinis, W-K Cho, X Gao, Y Shin, Y Zhang, YAG Fosado, Özgen Deniz   +105 more
core   +5 more sources

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Transposable element subfamily annotation has a reproducibility problem

Mobile DNA, 2021
Background Transposable element (TE) sequences are classified into families based on the reconstructed history of replication, and into subfamilies based on more fine-grained features that are often intended to capture family history.
Kaitlin M. Carey, Gilia Patterson, Travis J. Wheeler   +2 more
doaj   +1 more source

Transposable element sequence fragments incorporated into coding and noncoding transcripts modulate the transcriptome of human pluripotent stem cells [PDF]

, 2021
Isaac A. Babarinde, Gang Ma, Yuhao Li, Boping Deng, Zhiwei Luo, Hao Liu, Mazid Md. Abdul, Carl Ward, Minchun Chen, Xiuling Fu, Liyang Shi, Martha Duttlinger, Jiangping He, Li Sun, Wenjuan Li, Qiang Zhuang, Guoqing Tong, Jon Frampton, Jean‐Baptiste Cazier, Jiekai Chen, Ralf Jauch, Miguel A. Esteban, Andrew P. Hutchins   +22 more
openalex   +1 more source

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich, Tilman Schneider‐Hohendorf, Eric Baetscher, Evan L. Riddle, Marie Deffner, Emily Katsnelson, Janine Ferrant‐Orgettas, Julie Czerkowicz, John Anderson, Susan E. Goelz, Nicholas Schwab   +10 more
wiley   +1 more source