Results 81 to 90 of about 2,835,830 (298)

Activity and Silencing of Transposable Elements in C. elegans

DNA
Since the discovery of transposable elements (TEs) in maize in the 1940s by Barbara McClintock transposable elements have been described as junk, as selfish elements with no benefit to the host, and more recently as major determinants of genome structure
Sylvia E. J. Fischer
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology

Epigenetics & Chromatin
DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable ...
Alexandra Chera, Mircea Stancu-Cretu, Nicolae Radu Zabet, Octavian Bucur   +3 more
doaj   +1 more source

The biology and potential for genetic research of transposable elements in filamentous fungi

Genetics and Molecular Biology, 2005
Recently many transposable elements have been identified and characterized in filamentous fungi, especially in species of agricultural, biotechnological and medical interest.
Léia Cecilia de Lima Fávaro, Welington Luiz de Araújo, João Lúcio de Azevedo, Luzia Doretto Paccola-Meirelles   +3 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

EpiTEome: Simultaneous detection of transposable element insertion sites and their DNA methylation levels

Genome Biology, 2017
The genome-wide investigation of DNA methylation levels has been limited to reference transposable element positions. The methylation analysis of non-reference and mobile transposable elements has only recently been performed, but required both genome ...
Josquin Daron, R. Keith Slotkin
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Genome-wide comparison of cyanobacterial transposable elements, potential genetic diversity indicators

, 2011
Transposable elements are widely distributed in archaea, bacteria and eukarya domains. Considerable discrepancies of transposable elements in eukaryotes have been reported, however, the studies focusing on the diversity of transposable element systems in
vingron@molgen.mpg.de, Vingron, Martin, biolin@ihb.ac.cn, haas@molgen.mpg.de, xp@ihb.ac.cn, Zemojtel, Tomasz, zemojtel@molgen.mpg.de, Haas, Stefan, Xiao, Peng, Li, Renhui, Lin, Shen, Li, RH, Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat Biol, Wuhan 430072, Peoples R China, reli@ihb.ac.cn   +12 more
core  

Bioinformatic analysis of Entamoeba histolytica SINE1 elements. [PDF]

, 2010
BACKGROUND: Invasive amoebiasis, caused by infection with the human parasite Entamoeba histolytica remains a major cause of morbidity and mortality in some less-developed countries. Genetically E.
Derek M Huntley, Ioannis Pandis, John P Ackers, Huntley Derek M, Butcher, Sarah A, Sarah A Butcher, Pandis, Ioannis, Ackers, John P, Pandis Ioannis, Ackers John P, Butcher Sarah A, Huntley, Derek M   +11 more
core   +1 more source

Regulatory transposable elements in the encyclopedia of DNA elements

Nature Communications
Transposable elements (TEs) comprise ~50% of our genome, but knowledge of how TEs affect genome evolution remains incomplete. Leveraging ENCODE4 data, we provide the most comprehensive study to date of TE contributions to the regulatory genome.
Alan Y. Du, Jason D. Chobirko, Xiaoyu Zhuo, Cédric Feschotte, Ting Wang   +4 more
doaj   +1 more source