The Journal of Physiology, EarlyView.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
wiley +1 more source
Scientific ReportsThe pathophysiology of variant transthyretin (TTR) amyloidosis (ATTRv) is associated with destabilizing mutations in the TTR tetramer. However, why TTR with a wild-type genetic sequence misfolds and aggregates in wild-type transthyretin amyloidosis ...
Takuya Iino +11 more
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Regulation of Hepatic Transthyretin Messenger RNA Levels during Moderate Protein and Food Restriction in Rats [PDF]
, 1992 Béatrice Le Moullac +2 more
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Transthyretin amiloid fibrillumok nanobiofizikai vizsgálata = Nanobiophysical exploration of transthyretin amyloid fibrils [PDF]
, 2010 Kísérleteinkben AFM segítségével vizsgáltuk transthyretin (TTR) amiloid fibrillumok amiloidogén fibrillum képződési mechanizmusait. Protofibrillumokon végzett egyedi molekula erőspektroszkópiai mérések eredményeit a natív TTR szerkezeti paramétereivel ...
Karsai, Árpád +1 more
core
A new mutant transthyretin (Arg 10) associated with familial amyloid polyneuropathy. [PDF]
, 1992 Tomoyuki Uemichi +3 more
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Drug Discovery and Development in Rare Diseases: Taking a Closer Look at the Tafamidis Story
Drug Design, Development and Therapy, 2021 Arianna Burton,1 Adam Castaño,1 Marianna Bruno,1 Steve Riley,2 Jennifer Schumacher,1 Marla B Sultan,3 Sandi See Tai,4 Daniel P Judge,5 Jignesh K Patel,6 Jeffery W Kelly7 1Medical Affairs, Pfizer Inc, New York, NY, USA; 2Clinical Pharmacology ...
Burton A +9 more
doaj
Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice. [PDF]
, 1990 Chenghui Yan +4 more
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The Interplay of Cross‐Organ Immune Regulation in Inflammation and Cancer
MedComm, Volume 6, Issue 7, July 2025.Organs interact dynamically through immune regulation, influencing systemic immune responses and disease progression. We review molecular and cellular mechanisms of cross‐organ immune regulation in inflammation and cancer, focusing on gut, liver, and brain interactions with other organs.
Jie Dou +6 more
wiley +1 more source
Liver International, Volume 45, Issue 7, July 2025.ABSTRACT Background and Aims Liver fibrosis, a progressive condition driven by chronic liver injury and excessive scar tissue formation, can lead to cirrhosis, a life‐threatening disease. Activation of hepatic stellate cells (HSCs) is central to fibrosis progression, yet current therapies fail to halt or reverse this process.
Xiang‐Jie Zhu +13 more
wiley +1 more source
The piscine plasma retinol-binding protein. Purification, partial amino acid sequence and interaction with mammalian transthyretin of rainbow trout (Oncorhynchus mykiss) retinol-binding protein [PDF]
, 1992 R. Berni +2 more
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