Results 121 to 130 of about 51,205 (281)

Induced Circular Dichroism From the Binding of Achiral Bivalent Ligands to Transthyretin

Journal of Molecular Recognition, Volume 39, Issue 3, May 2026.
ABSTRACT Achiral bivalent ligands capable of simultaneous occupation of both hormone binding sites of transthyretin generate a substantial and complex induced near ultraviolet circular dichroism spectrum during protein binding, revealing the dynamics of this process.
Stephen Wood, Yiwei Guan, James Pitts, Raj Gill, Simon Kolstoe, Támas Jávorfi, Rohanah Hussain, Giuliano Siligardi   +7 more
wiley   +1 more source

Real-life experience with inotersen at CEPARM, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro

Arquivos de Neuro-Psiquiatria
Background Hereditary transthyretin amyloidosis (ATTRv) is an inherited, progressive, and fatal disease still largely underdiagnosed. Mutations in the transthyretin (TTR) gene cause the TTR protein to destabilize, misfold, aggregate, and ...
Moises Dias, Luiz Felipe Pinto, Marcus Vinícius Pinto, Renata Gervais, Paula Accioli, Gabriela Amorim, Mariana Guedes, Carlos Perez Gomes, Roberto Coury Pedrosa, Márcia Waddington-Cruz   +9 more
doaj   +1 more source

Familial amyloid polyneuropathy associated with TTRSer50Arg mutation in two Iberian families presenting a novel single base change in the mutant gene [PDF]

, 2007
Amyloid. 2007 Jun;14(2):147-52. Familial amyloid polyneuropathy associated with TTRSer50Arg mutation in two Iberian families presenting a novel single base change in the mutant gene.
COELHO, T, MASJUAN, J., MOREIRA, P., MUNAR‐QUÉS, M., SARAIVA, M.J., VIADER‐FARRÉ, C.   +5 more
core   +1 more source

Palinacousis in amyloidosis: exploring the hallucinatory phenomenon in brain pathology—a case report

Journal of Medical Case Reports
Background Hereditary transthyretin amyloidosis, caused by transthyretin gene mutations, progresses with systemic impact and often presents peripheral neuropathy.
João Martins-Correia, Luísa Sousa
doaj   +1 more source

Piscine (Sparus aurata) transthyretin cDNA cloning and characterization [PDF]

, 1997
Transthyretin (TTR) is one of the three plasma proteins that participate in the transport of thyroid hormones, thyroxine (T4) and triiodothyronine (T3); it is also involved in the carriage of retinol through the mediation of retinol-binding protein.1 ...
Achen M. G., Duan W., Duan W., Richardson S.   +3 more
core   +1 more source

Optimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,
Ye Yuan, Vishnu Sharma, Venkatesh Atul Bhattaram, Xiaolei Pan, Justin Earp, Yun Wang, Jiang Liu, Hao Zhu   +7 more
wiley   +1 more source

A possible role for miRNA silencing in disease phenotype variation in Swedish transthyretin V30M carriers [PDF]

, 2010
Our results are the first to show the presence of a 3'UTR polymorphism on the V30M haplotype in Swedish carriers, which can serve as a miRNA binding site potentially leading to down-regulated expression from the mutated TTR allele.
Jenni Jonasson, Konen Obayashi, Kristina Cederquist, Malin Olsson, Nina Norgren, Ole B Suhr, Violaine Plante-Bordeneuve   +6 more
core   +3 more sources

Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis

Drug Design, Development and Therapy, 2019
Veena Mathew,1 Annabel K Wang1,2 1Department of Neurology, UCI ALS and Neuromuscular Center, University of California, Irvine, Orange, CA, USA; 2Neurology Section, Tibor Rubin VA Medical Center, Long Beach, CA, USA Abstract: Hereditary transthyretin ...
Mathew V, Wang AK
doaj  

The hydrophobic C‐terminal sequence of transthyretin affects its catalytic kinetics towards amidated neuropeptide Y

FEBS Open Bio, 2019
Transthyretin (TTR) is a transporter for thyroid hormone and retinol binding protein that has recently been reported to have proteolytic activity against certain substrates, including amidated neuropeptide Y (NPY).
Sukanya Tangthavewattana, Ladda Leelawatwattana, Porntip Prapunpoj   +2 more
doaj   +1 more source

A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH [PDF]

, 2019
Mitsuharu Ueda, Masamitsu Okada, Mineyuki Mizuguchi, Barbara Kluve‐Beckerman, Kyosuke Kanenawa, Aito Isoguchi, Yohei Misumi, Masayoshi Tasaki, Akihiko Ueda, Akinori Kanai, Ryoko Sasaki, Teruaki Masuda, Yasuteru Inoue, Toshiya Nomura, Satoru Shinriki, Tsuyoshi Shuto, Hirofumi Kai, Taro Yamashita, Hirotaka Matsui, Merrill D. Benson, Yukio Ando   +20 more
openalex   +1 more source