Results 121 to 130 of about 32,046 (240)

New Medications in the Treatment of Hereditary Transthyretin Amyloidosis

, 2018
Hereditary transthyretin amyloidosis is an inherited disorder that results in the gradual progressive deposit of abnormal protein called amyloid in the body’s organs and tissues.
Scot Walker
core   +1 more source

Impact of Baseline Polyneuropathy Severity on Eplontersen Efficacy in the NEURO‐TTRansform Clinical Trial

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims In the NEURO‐TTRansform clinical trial (NCT04136184), eplontersen improved neuropathy impairment and quality of life (QoL) through Week 66 versus the NEURO‐TTR historical placebo in patients with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv‐PN).
Thomas H. Brannagan III, Markus Weiler, Márcia Waddington Cruz, Sami Khella, John L. Berk, Morie Gertz, Ahmad Masri, Mathew S. Maurer, Jonas Wixner, Jonatan Nåtman, T. Jesse Kwoh, Maksym Pola, Laura Obici   +12 more
wiley   +1 more source

Effect of Dietary Vitamin A, Breed, and Kidney Function on the Onset of Urinary Vitamin A Excretion and the Vitamin A Transport Complex in Growing Dogs

Journal of Animal Physiology and Animal Nutrition, Volume 110, Issue 5, Page 813-819, September 2026.
ABSTRACT Vitamin A (retinol and retinyl esters) is present in substantial amounts in the urine of healthy adult dogs, but the mechanisms affecting its excretion are poorly understood. To assess whether the onset of urinary vitamin A excretion is dependent on dietary vitamin A intake, breed, and/or parameters of kidney function, 48 puppies from two ...
Jens Raila, Haydar Özpinar, Florian J. Schweigert   +2 more
wiley   +1 more source

Assessment of transthyretin instability in patients with wild-type transthyretin amyloid cardiomyopathy

The pathophysiology of variant transthyretin (TTR) amyloidosis (ATTRv) is associated with destabilizing mutations in the TTR tetramer. However, why TTR with a wild-type genetic sequence misfolds and aggregates in wild-type transthyretin amyloidosis ...
Shunsuke Watanabe, Tatsuro Ishida, Takuya Iino, Sachiko Yoshikawa, Makoto Nishimori, Amane Harada, Ken-ichi Hirata, Ryuji Toh, Masakazu Shinohara, Junko Asakura, Manabu Nagao, Hidekazu Tanaka   +11 more
core   +1 more source

Medicinal and Crop Protection Chemistry: Breaking Barriers, Building Synergies

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A unified view of medicinal and crop protection chemistry reveals shared scientific progress, common challenges, and new opportunities for cross‐disciplinary collaboration. Bridging expertise across both fields could accelerate innovation and actively encourage more sustainable solutions.
Giulia Cazzaniga, Giusy L. Fratello, Alexander T. Apostle, Roberto Orru, David M. Barber, Silvia Gazzola   +5 more
wiley   +1 more source

Genetic stabilization of transthyretin, cerebrovascular disease, and life expectancy

, 2013
Transthyretin can cause amyloidosis attributable to destabilization of transthyretin tetramers in plasma. We tested the hypothesis that genetic stabilization of transthyretin associates with reduced risk of vascular disease and increased life expectancy.
Tybjærg-Hansen, Anne, Frikke-Schmidt, Ruth, Nordestgaard, Børge G, Hornstrup, Louise S   +3 more
core   +1 more source

Reply to “Sural/Radial Amplitude Ratio in Non‐Length‐Dependent Neuropathy (NLDN): A Call for More Standardized Methodology and Further Evaluation of Distal NLDN”

Muscle &Nerve, Volume 74, Issue 3, Page 761-762, September 2026.
Antoine Pegat, Guillaume Fargeot, Françoise Bouhour   +2 more
wiley   +1 more source

Experience of Hereditary Amyloidosis with Rare Variant in Ecuador: Case Reports

Medical Sciences
More than approximately 120 transthyretin mutations are known. Their clinical presentation is heterogeneous, as the course of disease onset depends on genetic variation and level of penetrance.
Diana Elizabeth Luzuriaga Carpio, Borys Roberto Abrigo Maldonado, Humberto Villacorta   +2 more
doaj   +1 more source

Patient characteristics for men and women with transthyretin amyloidosis.

, 2015
Type A, mixture of intact and fragmented transthyretin; Type B, only full length transthyretin. Continuous data are presented as median (range) and categorical data are presented as counts and percentages. Statistically significant differences are marked
Per Westermark (79625), Björn Pilebro (829908), Per Lindqvist (829909), Ole B. Suhr (298443), Sandra Arvidsson (829907)   +4 more
core   +1 more source

Transthyretin [PDF]

, 2020
openaire   +1 more source