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Transthyretin Mass Determination for Detection of Transthyretin Familial Amyloid
2009The concentration range of plasma proteins exceeds the dynamic range of any single analytical method. It has been estimated that the concentration range of serum proteins exceeds ten orders of magnitude (1). Because of this, prior immunoselection of even abundant proteins facilitates the relative nonquantitative observations required to show structural
John F, O'Brien, H Robert, Bergen
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Transthyretin and the Transthyretin Amyloidoses
2007Transthyretin is a normal serum protein that carries the secondary thyroid hormone thyroxine and retinol binding protein when it is loaded with retinol. It is synthesized primarily in the liver but there is also significant production in the choroid plexus and the retina. Both message and protein are found in the kidney but that site does not appear to
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Computational Studies on Transthyretin
Current Medicinal Chemistry, 2012Among the 23 different fibril proteins described in human amyloidosis, transthyretin is associated with the most common hereditary form of the disease and its knowledge is corroborated through about 150 crystal structures in addition to thousands of small ligands tested as fibril formation inhibitors. In spite of the large amount of available data, the
ORTORE, GABRIELLA MARIA PIA +1 more
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Clusterin regulates transthyretin amyloidosis
Biochemical and Biophysical Research Communications, 2009Transthyretin (TTR) is a human disease-associated amyloidogenic protein that has been implicated in senile systemic amyloidosis (SSA) and familial amyloidotic polyneuropathy (FAP). FAP typically results in severe and early-onset disease, and the only therapy established so far is liver transplantation; thus, developing new strategies for treating FAP ...
Ko-Woon, Lee +9 more
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Transthyretin familial amyloid polyneuropathy
2013TTR FAP is characterized by phenotypic and genotypic heterogeneity. The severity of polyneuropathy along with autonomic dysfunction and heart involvement makes it a life-threatening disease. This protein is mainly produced by the liver. Molecular genetic testing is essential in the diagnostic strategy.
V, Planté-Bordeneuve, P, Kerschen
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Transthyretin amyloid cardiomyopathy
The American Journal of the Medical Sciences, 2023Giuseppe, Famularo, Guido, Ventroni
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Hereditary transthyretin-related amyloidosis
Acta Neurologica Scandinavica, 2018Hereditary transthyretin(TTR)-related amyloidosis (ATTRm amyloidosis) is an endemic/non-endemic, autosomal-dominant, early- and late-onset, rare, progressive disorder, predominantly manifesting as length-dependent, small fiber dominant, axonal polyneuropathy and frequently associated with cardiac disorders and other multisystem diseases.
Josef Finsterer +5 more
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Monoclonal antibodies to transthyretin
Scandinavian Journal of Clinical and Laboratory Investigation, 1986Monoclonal antibodies (mabs) have been raised against human transthyretin (hTTR). The protein was isolated by an affinity chromatography procedure using Sepharose-hRBP and BALB/c mice were immunized. Following fusion with SP 2/0 myeloma cells, 26 single cell clones producing antibodies against hTTR were isolated.
V P, Collins +3 more
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Transthyretin familial amyloid polyneuropathy
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2018Transthyretin family amyloid polyneuropathy (TTR-FAP) is a progressive, ultimately fatal disease. It manifests itself primarily with sensory, motor and autonomic polyneuropathy and/or cardiomyopathy and is caused by extracellular deposition of insoluble amyloid fibrils in the endoneurium.
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