Results 191 to 200 of about 60,909 (346)
Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components
Small Methods, EarlyView.The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu +6 more
wiley +1 more source
Cell Proliferation, EarlyView.CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far +4 more
wiley +1 more source
Hereditary Transthyretin Amyloidosis in Patients Referred to a Genetic Testing Program
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Diagnosis of hereditary amyloid transthyretin (hATTR) amyloidosis with cardiomyopathy is frequently delayed, in large part because of symptom overlap with other cardiovascular diseases and limited provider knowledge of this disease.
Kunal Bhatt +13 more
doaj +1 more source
New markers of bulk milk quality in relation to mastitis [PDF]
, 2009 All dairy processors depend on a continuous supply of high-quality bulk milk from milk producers to be able to distribute liquid milk and dairy products.
Wickström, Erik
core
A new mutant transthyretin (Arg 10) associated with familial amyloid polyneuropathy. [PDF]
, 1992 Tomoyuki Uemichi +3 more
openalex +1 more source
Autophagy in PE: Dispute, Role and Potential Target
Cell Proliferation, EarlyView.Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu +12 more
wiley +1 more source
Central nervous system involvement in cardiac amyloidosis: Redefining the heart‐brain axis
European Journal of Clinical Investigation, EarlyView.Central nervous system involvement in cardiac amyloidosis. Amyloidosis is a systemic disease that can directly affect the central nervous system. Furthermore, the amyloid cardiomyopathy can indirectly affect the central nervous system by inducing systemic hypoperfusion and increasing the risk of acute ischaemic stroke.
Domenico Mario Giamundo +3 more
wiley +1 more source
Guanidine Hydrochloride-Induced Denaturation and Refolding of Transthyretin Exhibits a Marked Hysteresis: Equilibria with High Kinetic Barriers [PDF]
, 1997 Zhihong Lai +3 more
openalex +1 more source