Widespread Skin Lesions in an Italian Man
JEADV Clinical Practice, EarlyView.
Rebecca Donadoni +7 more
wiley +1 more source
Clinical Utility of Serum Neurofilament Light Chain in Peripheral Neuropathy
Muscle &Nerve, Volume 73, Issue 1, Page 86-92, January 2026.ABSTRACT Introductions/Aims The clinical utility of serum neurofilament light chain (sNfL) in the evaluation and management of peripheral neuropathy (PN) remains poorly defined. This study aimed to evaluate the utility of sNfL for diagnosing PN, assessing disease activity, and monitoring treatment response using a commercially available assay.
Chafic Karam
wiley +1 more source
A Sustainable Visible Light‐Mediated Synthesis of Benzoxazole 2‐Carboxylates/Carboxamides
Chemistry – A European Journal, Volume 31, Issue 68, December 4, 2025.An efficient photochemical protocol for the synthesis of 2‐ester or 2‐amide benzoxazoles was developed, utilizing 1,8‐dihydroxyanthraquinone and CuI as the photocatalytic system under LED 427 nm irradiation. Furthermore, 2‐ester/amide benzoxazoles serve as intermediates for the synthesis of potentially valuable compounds.
Anna‐Dimitra D. Gerogiannopoulou +4 more
wiley +1 more source
CSF Mitochondrial DNA: Biomarker of Body Composition and Energy Metabolism in Parkinson's Disease
Annals of Clinical and Translational Neurology, Volume 12, Issue 12, Page 2410-2421, December 2025.ABSTRACT Objective Cerebrospinal fluid (CSF) cell‐free mitochondrial DNA (cf‐mtDNA) is a potential biomarker for Parkinson's disease (PD), but its clinical relevance remains unclear. We investigated associations between CSF cf‐mtDNA levels, body composition, nutritional status, and metabolic biomarkers in PD. Methods CSF cf‐mtDNA levels, defined as the
Yasuaki Mizutani +11 more
wiley +1 more source
ACR Open Rheumatology, Volume 7, Issue 12, December 2025.Although individually occurring in less than 1 in 2,000 people, cumulatively, more than 7,000 rare diseases affect approximately 6% of the population worldwide. Children and young people are disproportionally challenged in number and severity, which may be explained by the large proportion of genetic conditions among rare diseases (70%–80%). Indeed, an
Christian M. Hedrich
wiley +1 more source
Ligand efficiency indices as a navigation tool in the transthyretin protein chemico-biological space to find new amyloidogenic inhibitors [PDF]
, 2011 D. Blasi +8 more
openalex +1 more source
Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery
Advanced Functional Materials, Volume 35, Issue 49, December 2, 2025.This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer +10 more
wiley +1 more source
Advanced Functional Materials, Volume 35, Issue 51, December 16, 2025.This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras +19 more
wiley +1 more source
Detection of Genetic Variants of Transthyretin by Liquid Chromatography–Dual Electrospray Ionization Fourier-Transform Ion-Cyclotron-Resonance Mass Spectrometry [PDF]
, 2004 Angelito I. Nepomuceno +4 more
openalex +1 more source
Modulation of the Mechanisms Driving Transthyretin Amyloidosis [PDF]
, 2020 Filipa Bezerra +2 more
openalex +1 more source