Results 201 to 210 of about 28,989 (238)

Transthyretin and the human placenta

Placenta, 2013
Since its discovery, transthyretin (TTR) has been regarded as an important hepatically derived protein carrier of thyroid hormones and retinol in blood. However, in more recent years it has been shown that TTR has other important functions. TTR is abundant in cerebrospinal fluid, where it may be involved in transport of thyroid hormones into the brain.
Landers, K. A., Mortimer, R. H., Richard, K.   +2 more
openaire   +5 more sources

Transthyretin Mass Determination for Detection of Transthyretin Familial Amyloid

2009
The concentration range of plasma proteins exceeds the dynamic range of any single analytical method. It has been estimated that the concentration range of serum proteins exceeds ten orders of magnitude (1). Because of this, prior immunoselection of even abundant proteins facilitates the relative nonquantitative observations required to show structural
John F, O'Brien, H Robert, Bergen
openaire   +2 more sources

Transthyretin Cardiac Amyloidosis

Current Cardiology Reports, 2017
Transthyretin (TTR)-related cardiac amyloidosis is a progressive infiltrative cardiomyopathy that mimics hypertensive, hypertrophic heart disease and may go undiagnosed. Transthyretin-derived amyloidosis accounts for 18% of all cases of cardiac amyloidosis.
Anit K, Mankad, Keyur B, Shah
openaire   +2 more sources

Acoramidis: A New Transthyretin Stabilizer for Transthyretin Amyloid Cardiomyopathy

Annals of Pharmacotherapy
Objective: The objective of the study was to review acoramidis, a new transthyretin stabilizer, for treatment of transthyretin amyloid cardiomyopathy by means of pharmacology, efficacy, and safety. Data sources: An Embase, PubMed, and ...
Taylor Clark, Rachel Lucas, Azadeh Nasuhidehnavi, Nathan Sauers, Kelly Bach   +4 more
openaire   +2 more sources

Localization of transthyretin-mRNA and of immunoreactive transthyretin in the human fetus

Virchows Archiv A Pathological Anatomy and Histopathology, 1989
Five human fetuses at mid-term (16-20 weeks) and one with a gestational age of 8 weeks were investigated. The cellular localization of transthyretin (TTR)-mRNA in different organs was demonstrated by in situ hybridization with a 35S-labelled, single-stranded RNA probe. Immunoreactive TTR (TTR-IR) was localized with a monoclonal antibody to TTR.
openaire   +2 more sources

Transthyretin and the Transthyretin Amyloidoses

2007
Transthyretin is a normal serum protein that carries the secondary thyroid hormone thyroxine and retinol binding protein when it is loaded with retinol. It is synthesized primarily in the liver but there is also significant production in the choroid plexus and the retina. Both message and protein are found in the kidney but that site does not appear to
openaire   +1 more source

Monoclonal antibodies to transthyretin

Scandinavian Journal of Clinical and Laboratory Investigation, 1986
Monoclonal antibodies (mabs) have been raised against human transthyretin (hTTR). The protein was isolated by an affinity chromatography procedure using Sepharose-hRBP and BALB/c mice were immunized. Following fusion with SP 2/0 myeloma cells, 26 single cell clones producing antibodies against hTTR were isolated.
V P, Collins, B, Jacobsson, T, Pettersson, A, Carlström   +3 more
openaire   +2 more sources

Tafamidis for transthyretin amyloidosis

Drugs of Today, 2012
Tafamidis meglumine (Vyndaqel®, Pfizer) is a novel, first-in-class drug for the treatment of transthyretin familial amyloid polyneuropathy (TTR-FAP), a rare neurodegenerative disorder characterized by progressive sensory, motor and autonomic impairment that is ultimately fatal.
openaire   +2 more sources

Transthyretin amyloid cardiomyopathy

Ugeskrift for Læger
Transthyretin amyloidosis (ATTR-CM) is an infiltrative cardiomyopathy caused by the deposition of amyloid fibrils, leading to heart failure, arrhythmias, and increased mortality. ATTR-CM prevalence is rising. The first disease-modifying drugs have been approved and implemented in Denmark.
Sie Kronborg, Fensman, Ale Hussein Jaber, Mejren, Tor Skibsted, Clemmensen, Steen Hvitfeldt, Poulsen   +3 more
openaire   +2 more sources

Cardiac transthyretin amyloidosis

Heart, 2012
Cardiac amyloidosis of transthyretin fibril protein (ATTR) type is an infiltrative cardiomyopathy characterised by ventricular wall thickening and diastolic heart failure. Increased access to cardiovascular magnetic resonance imaging has led to a marked increase in referrals to our centre of Caucasian patients with wild-type ATTR (senile systemic ...
Jason N, Dungu, Lisa J, Anderson, Carol J, Whelan, Philip N, Hawkins   +3 more
openaire   +2 more sources