Results 191 to 200 of about 28,989 (238)

Sodium-Glucose Cotransporter-2 Inhibitors Therapy in Transthyretin Amyloid Cardiomyopathy: A Propensity-Matched Cohort Study. [PDF]

Int J Heart Fail
Pinheiro L, de Castro M, Mata E, Lage Garcia B, Pereira T, Cordeiro F, Azevedo O, Lourenço A.   +7 more
europepmc   +1 more source

Long-Term Durability of Acoramidis Efficacy in Transthyretin Amyloid Cardiomyopathy: Open-Label Extension of the ATTRibute-CM Randomized Clinical Trial.

JAMA Cardiol
Soman P, Cuddy SAM, Gillmore JD, Sarswat N, Judge DP, Cappelli F, Stern LK, Wright R, Akinboboye O, Obici L, Bhatt K, Xiong K, Castaño A, Chen C, Falvey H, Pecoraro ML, Tamby JF, Sinha U, Fox JC, Shah K, Grodin JL, Ambardekar AV, Alexander KM, Khouri MG, Cheng RK.   +24 more
europepmc   +1 more source

Comparative Stability and Clearance of [Met30]Transthyretin and [Met119]Transthyretin [PDF]

FEBS Journal, 1997
[Met119]Transthyretin has been described as a non‐amyloidogenic transthyretin variant. In Portugal, it has also been found in compound heterozygotic individual carriers of [Met30]transthyretin, the most prevalent variant associated with familial amyloidotic polyneuropathy.
I L Alves, Marguerite T Hays, Maria João Saraiva   +2 more
exaly   +3 more sources

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Wallaby transthyretin

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1995
A cDNA library was constructed from liver RNA of the Australian diprotodont marsupial Macropus eugenii, the Tammar wallaby. A cloned full-length transthyretin cDNA was sequenced. The derived amino-acid sequence showed 68% overall similarity to that of human transthyretin, with 86% similarity in the thyroxine binding site.
C M, Brack, W, Duan, A J, Hulbert, G, Schreiber   +3 more
openaire   +2 more sources

Transthyretin amyloid cardiomyopathy

Medicina Clínica (English Edition), 2021
Transthyretin (TTR) cardiac amyloidosis is a severe, progressive, infiltrative disease caused by the deposition of TTR at cardiac level. It may be due to a genetic alteration in its hereditary form (ATTRv) or as a consequence of an age-related degenerative process (ATTRwt). Thanks to advances in imaging techniques and the possibility of achieving a non-
Pablo, Garcia-Pavia, Fernando, Domínguez, Esther, Gonzalez-Lopez   +2 more
openaire   +2 more sources

Hereditary transthyretin amyloidosis associated with a transthyretin variant Thr59Arg

Amyloid, 2017
Hereditary transthyretin (TTR) amyloidosis is characterized by ATTR amyloid deposits in various tissue sites and organs, such as peripheral nerves, heart, gastrointestinal tract, kidneys, eyes, and...
Tetsuya, Watanabe, Konen, Obayashi, Yohei, Misumi, Masayoshi, Tasaki, Satoru, Shinriki, Tomotaka, Ando, Takafumi, Akagami, Mitsuharu, Ueda, Taro, Yamashita, Shinichi, Hirotani, Yukio, Ando   +10 more
openaire   +2 more sources

Investigation into thiol conjugation of transthyretin in hereditary transthyretin amyloidosis

European Journal of Clinical Investigation, 1998
BackgroundFor all forms of amyloidosis, the amyloid‐generating mechanism is unknown. Familial amyloidotic polyneuropathy type I is caused by a variant transthyretin (TTR Met‐30). As electrospray ionization mass spectrometry (ESI‐MS) discloses both thiol‐conjugated and ‐unconjugated forms of wild‐type and variant TTR, we wanted to investigate the ...
O B, Suhr, Y, Ando, P I, Ohlsson, A, Olofsson, K, Andersson, E, Lundgren, M, Ando, G, Holmgren   +7 more
openaire   +2 more sources

Structural and functional evolution of transthyretin and transthyretin‐like proteins

Proteins: Structure, Function, and Bioinformatics, 2006
AbstractTransthyretin (TTR) is a tetrameric protein involved in the distribution of thyroid hormones in vertebrates. The amino acid sequence of TTR is highly conserved across vertebrates. Hypothetical TTR‐like proteins (TLPs) were inferred from the identification of genes in nonvertebrate species. Here, we identified five motifs defining TLPs and three
Sarah C, Hennebry, Hannah M, Wright, Vladimir A, Likic, Samantha J, Richardson   +3 more
openaire   +2 more sources

Transthyretin-Related and Transthyretin-like Proteins

2009
Bioinformatics programs are highly accurate in identifying protein families directly from protein sequences, even when the sequence identity is very low. The transthyretin-related proteins (TRPs) are one example of a protein family that has been identified.
A. Elisabeth Sauer-Eriksson, Anna Linusson, Erik Lundberg   +2 more
openaire   +1 more source