Results 191 to 200 of about 32,046 (240)
Some of the next articles are maybe not open access.
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1995
A cDNA library was constructed from liver RNA of the Australian diprotodont marsupial Macropus eugenii, the Tammar wallaby. A cloned full-length transthyretin cDNA was sequenced. The derived amino-acid sequence showed 68% overall similarity to that of human transthyretin, with 86% similarity in the thyroxine binding site.
C M, Brack +3 more
openaire +2 more sources
A cDNA library was constructed from liver RNA of the Australian diprotodont marsupial Macropus eugenii, the Tammar wallaby. A cloned full-length transthyretin cDNA was sequenced. The derived amino-acid sequence showed 68% overall similarity to that of human transthyretin, with 86% similarity in the thyroxine binding site.
C M, Brack +3 more
openaire +2 more sources
Transthyretin amyloid cardiomyopathy
Medicina Clínica (English Edition), 2021Transthyretin (TTR) cardiac amyloidosis is a severe, progressive, infiltrative disease caused by the deposition of TTR at cardiac level. It may be due to a genetic alteration in its hereditary form (ATTRv) or as a consequence of an age-related degenerative process (ATTRwt). Thanks to advances in imaging techniques and the possibility of achieving a non-
Pablo, Garcia-Pavia +2 more
openaire +2 more sources
Structural and functional evolution of transthyretin and transthyretin‐like proteins
Proteins: Structure, Function, and Bioinformatics, 2006AbstractTransthyretin (TTR) is a tetrameric protein involved in the distribution of thyroid hormones in vertebrates. The amino acid sequence of TTR is highly conserved across vertebrates. Hypothetical TTR‐like proteins (TLPs) were inferred from the identification of genes in nonvertebrate species. Here, we identified five motifs defining TLPs and three
Sarah C, Hennebry +3 more
openaire +2 more sources
Investigation into thiol conjugation of transthyretin in hereditary transthyretin amyloidosis
European Journal of Clinical Investigation, 1998BackgroundFor all forms of amyloidosis, the amyloid‐generating mechanism is unknown. Familial amyloidotic polyneuropathy type I is caused by a variant transthyretin (TTR Met‐30). As electrospray ionization mass spectrometry (ESI‐MS) discloses both thiol‐conjugated and ‐unconjugated forms of wild‐type and variant TTR, we wanted to investigate the ...
O B, Suhr +7 more
openaire +2 more sources
Hereditary transthyretin amyloidosis associated with a transthyretin variant Thr59Arg
Amyloid, 2017Hereditary transthyretin (TTR) amyloidosis is characterized by ATTR amyloid deposits in various tissue sites and organs, such as peripheral nerves, heart, gastrointestinal tract, kidneys, eyes, and...
Tetsuya, Watanabe +10 more
openaire +2 more sources
Transthyretin-Related and Transthyretin-like Proteins
2009Bioinformatics programs are highly accurate in identifying protein families directly from protein sequences, even when the sequence identity is very low. The transthyretin-related proteins (TRPs) are one example of a protein family that has been identified.
A. Elisabeth Sauer-Eriksson +2 more
openaire +1 more source
Transthyretin and the human placenta
Placenta, 2013Since its discovery, transthyretin (TTR) has been regarded as an important hepatically derived protein carrier of thyroid hormones and retinol in blood. However, in more recent years it has been shown that TTR has other important functions. TTR is abundant in cerebrospinal fluid, where it may be involved in transport of thyroid hormones into the brain.
Landers, K. A. +2 more
openaire +5 more sources
Monoclonal antibodies to transthyretin
Scandinavian Journal of Clinical and Laboratory Investigation, 1986Monoclonal antibodies (mabs) have been raised against human transthyretin (hTTR). The protein was isolated by an affinity chromatography procedure using Sepharose-hRBP and BALB/c mice were immunized. Following fusion with SP 2/0 myeloma cells, 26 single cell clones producing antibodies against hTTR were isolated.
V P, Collins +3 more
openaire +2 more sources
Transthyretin and the Transthyretin Amyloidoses
2007Transthyretin is a normal serum protein that carries the secondary thyroid hormone thyroxine and retinol binding protein when it is loaded with retinol. It is synthesized primarily in the liver but there is also significant production in the choroid plexus and the retina. Both message and protein are found in the kidney but that site does not appear to
openaire +1 more source
Transthyretin Mass Determination for Detection of Transthyretin Familial Amyloid
2009The concentration range of plasma proteins exceeds the dynamic range of any single analytical method. It has been estimated that the concentration range of serum proteins exceeds ten orders of magnitude (1). Because of this, prior immunoselection of even abundant proteins facilitates the relative nonquantitative observations required to show structural
John F, O'Brien, H Robert, Bergen
openaire +2 more sources