Results 201 to 210 of about 61,872 (307)

Microneedles From Shape‐Preserving Crosslinked Poly(Vinyl Alcohol) Hydrogels: Minimising Interference in Transdermal Proteomics

Advanced Materials Technologies, Volume 10, Issue 23, December 3, 2025.
Hydrogel‐forming microneedle patches are developed using shape‐preserving PVA‐PVP hydrogels, with and without chitosan, for minimally invasive transdermal protein biomarker sampling. The optimised patches enable efficient interstitial fluid uptake and proteomic analysis, while minimising interference.
Achmad Himawan, Robert Graham, Fabiana Volpe‐Zanutto, Huanhuan Li, Anjali K. Pandya, Andi Nur Aisyah, Rina Agustina, Juan L. Paris, Juan Dominguez‐Robles, Lalitkumar K. Vora, Andi D. Permana, Christopher J. Scott, Ryan F. Donnelly   +12 more
wiley   +1 more source

Modeling of Survival and Frequency of Cardiovascular-Related Hospitalization in Patients with Transthyretin Amyloid Cardiomyopathy Treated with Tafamidis [PDF]

, 2021
Camille Vong, Martin Boucher, Steve Riley, Lutz Harnisch   +3 more
openalex   +1 more source

A Case of AL Amyloidosis With Hepatomegaly as the Main Clinical Manifestation

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Light chain (AL) amyloidosis presenting predominantly with hepatomegaly is a rare and frequently misdiagnosed condition. While clinical features are non‐specific, elevated ALP/GGT should raise suspicion. A liver biopsy remains the gold standard for diagnosis.
Shuchen Dong, Renjun Lv, Wei Wang, Guoling Gao, Mingfeng Zhao, Xingbin Ma   +5 more
wiley   +1 more source

Molecular mechanisms of transthyretin-induced cytotoxicity

, 2017
Xu Hou
openalex   +1 more source

Inadequate Attempts to Measure the Microheterogeneity of Transthyretin by Low-Resolution Mass Spectrometry [PDF]

, 2005
Douwe de Boer, Matthias M Erps, Will KWH Wodzig, Marja P. van Dieijen‐Visser   +3 more
openalex   +1 more source

Impact of Carpal Tunnel Syndrome Surgery on Early Diagnosis and Treatment of Transthyretin Cardiac Amyloidosis [PDF]

, 2023
Inesa Kuznecova, Gerda Mierkytė, Dainius Jančiauskas, Donatas Vajauskas, Antanas Jankauskas, Loreta Pilipaitytė, Rytis Rimdeika, Vytautas Tamaliūnas, Eglė Ereminienė   +8 more
openalex   +1 more source

Exploitation of Biocomputational Approaches for siRNA‐Mediated Gene Silencing of HPV: A Novel Therapeutic Strategy for Cervical Cancer

Cancer Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background With recurrent high‐risk human papillomavirus (HPV) infections, especially HPV16 and HPV18, cervical cancer is the fourth most common disease among women. The functional alterations of the E6 and E7 proteins are essential to the oncogenic process of high‐risk HPVs and cervical cancer development.
Md. Habib Ullah Masum, Rehana Parvin, Homaira Pervin Heema, Aklima Akter, Jannatul Ferdous   +4 more
wiley   +1 more source

Extracardiac Accumulation of Technetium-99m-Pyrophosphate in Transthyretin Cardiac Amyloidosis

, 2021
Koji Takahashi, Daisuke Sasaki, Tomoki Sakaue, Daijiro Enomoto, Shigeki Uemura, Takafumi Okura, Shuntaro Ikeda, Daichi Yamamoto, Taizo Kono, Nobuhisa Yamamura   +9 more
openalex   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1405-1421, December 2025.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Antisense oligonucleotides targeting valosin‐containing protein ameliorate muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
Multisystem proteinopathy 1 (MSP1), caused by gain‐of‐function VCP variants, leads to multisystem degeneration. Using VCP patient‐derived hiPSCs, skeletal muscle progenitor cells were generated to evaluate antisense oligonucleotide (ASO) therapy.
Pallabi Pal, Michele Carrer, Lan Weiss, Olga G. Jaime, Cheng Cheng, Alyaa Shmara, Victoria Boock, Danae Bosch, Marwan Youssef, Yasamin Fazeli, Megan Afetian, Tamar R. Grossman, Michael R. Hicks, Paymaan Jafar‐nejad, Virginia Kimonis   +14 more
wiley   +1 more source