ESC Heart Failure, 2021 A positive nuclear scintigraphy with hydroxy bisphosphonate bone tracer (99mTc‐HPD) is believed to have high sensitivity (>99%) and specificity (91%) for the diagnosis of transthyretin amyloid cardiomyopathy. We report the case of an 85‐year‐old man with
Cristina Chimenti +7 more
doaj +1 more source
Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures [PDF]
, 2016 BACKGROUND: Early diagnosis of familial transthyretin (TTR) amyloid diseases remains challenging because of variable disease penetrance. Currently, patients must have an amyloid positive tissue biopsy to be eligible for disease-modifying therapies ...
Buxbaum, J. +7 more
core +1 more source
PET-CMR in heart failure - synergistic or redundant imaging? [PDF]
, 2017 Imaging in heart failure (HF) provides data for diagnosis, prognosis and disease monitoring. Both MRI and nuclear imaging techniques have been successfully used for this purpose in HF.
Quail, MA, Sinusas, AJ
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Hereditary transthyretin amyloidosis: baseline characteristics of patients in the NEURO-TTR trial [PDF]
, 2018 Background: Hereditary transthyretin (ATTRm) amyloidosis is a rare, progressive and fatal disease with a range of clinical manifestations.Objective: This study comprehensively evaluates disease characteristics in a large, diverse cohort of patients with ...
Ackermann, Elizabeth J. +16 more
core +3 more sources
Frequency of and Prognostic Significance of Cardiac Involvement at Presentation in Hereditary Transthyretin-Derived Amyloidosis and the Value of N-Terminal Pro-B-Type Natriuretic Peptide [PDF]
, 2018 The aim of this study is to assess the prevalence of cardiac involvement in hereditary transthyretin-derived (ATTRm) amyloidosis at the time of diagnosis and to determine the diagnostic and clinical value of N-terminal pro-B-type natriuretic peptide (NT ...
Blokzijl, Hans +7 more
core +2 more sources
Amyloidogenicity assessment of transthyretin gene variants
Annals of Clinical and Translational Neurology, 2022 Objective Hereditary transthyretin‐mediated amyloidosis is a treatable condition caused by amyloidogenic variants in the transthyretin‐gene resulting in severe peripheral neuropathy or cardiomyopathy.
Nicolai B. Grether +11 more
doaj +1 more source
Diagnostic sensitivity of abdominal fat aspiration in cardiac amyloidosis [PDF]
, 2017 Aims: Congo red staining of an endomyocardial biopsy is the diagnostic gold-standard in suspected cardiac amyloidosis (CA), but the procedure is associated with the risk, albeit small, of serious complications, and delay in diagnosis due to the ...
Botcher, N +15 more
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A simple voltage/mass index increases the suspicion of amyloidotic cardiomyopathy: an electrocardiographic and echocardiographic study of 767 patients with increased left ventricular wall thickness due to different causes [PDF]
, 2015 Background-Amyloidotic cardiomyopathy (AC) can mimic true left ventricular hypertrophy (LVH), including hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD).
Quarta, Candida Cristina <1981>
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A Review of Tafamidis for the Treatment of Transthyretin-Related Amyloidosis [PDF]
, 2015 Transthyretin (TTR)-related amyloidosis (ATTR) is a devastating disease which affects a combination of organs including the heart and the peripheral nerves, and which has a fatal outcome if not treated within a average of 10 years.
Benson, Merril D. +1 more
core +1 more source
ESC Heart Failure, 2022 While 99mTc‐pyrophosphate scintigraphy is clearly useful in diagnosing transthyretin amyloid cardiomyopathy (ATTR‐CM), it is necessary to know the pitfalls of this test for proper use. We present a rare case of concurrent ATTR‐CM and amyloid light chain (
Hidenori Moriyama +8 more
doaj +1 more source