Results 61 to 70 of about 44,633 (211)

A phenomap of TTR amyloidosis to aid diagnostic screening

ESC Heart Failure, Volume 12, Issue 2, Page 1113-1118, April 2025.
Abstract Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in clinical practice.
Alexios S. Antonopoulos, Theodoros Tsampras, George Lazaros, Konstantinos Tsioufis, Charalambos Vlachopoulos   +4 more
wiley   +1 more source

Spectrum of transthyretin gene mutations and clinical characteristics of Polish patients with cardiac transthyretin amyloidosis

Cardiology Journal, 2022
BACKGROUND: Transthyretin amyloidosis (ATTR) is a rare, life-threatening systemic disorder. We present first findings on the cardiac hereditary ATTR in Poland.
Monika Gawor, Katarzyna Holcman, Maria Franaszczyk, Marta Lipowska, Piotr Michałek, Anna Teresińska, Zofia T. Bilińska, Paweł Rubiś, Magdalena Kostkiewicz, Wojciech Szot, Piotr Podolec, Jacek Grzybowski   +11 more
doaj   +1 more source

Exercise limitations in amyloid cardiomyopathy assessed by cardiopulmonary exercise testing—A multicentre study

ESC Heart Failure, Volume 12, Issue 2, Page 1326-1335, April 2025.
Abstract Aims Amyloid cardiomyopathy is caused by the deposition of light chain (AL) or transthyretin amyloid (ATTR) fibrils, that leads to a restrictive cardiomyopathy, often resulting in heart failure (HF) with preserved or reduced ejection fraction.
Robin Willixhofer, Mauro Contini, Michele Emdin, Damiano Magrì, Alice Bonomi, Elisabetta Salvioni, Fabrizio Celeste, Alberico Del Torto, Claudio Passino, Christophe D.J. Capelle, Chiara Arzilli, Emiliano Fiori, Nicolò Capra, Christina Kronberger, Nikita Ermolaev, Andreas Kammerlander, Beatrice Musumeci, Giuseppe Vergaro, Vincenzo Castiglione, René Rettl, Giacomo Tini, Andrea Baggiano, Iacopo Fabiani, Susanna Sciomer, Roza Badr Eslam, Piergiuseppe Agostoni   +25 more
wiley   +1 more source

Patient characteristics for men and women with transthyretin amyloidosis.

, 2015
Type A, mixture of intact and fragmented transthyretin; Type B, only full length transthyretin. Continuous data are presented as median (range) and categorical data are presented as counts and percentages. Statistically significant differences are marked
Per Westermark (79625), Björn Pilebro (829908), Per Lindqvist (829909), Ole B. Suhr (298443), Sandra Arvidsson (829907)   +4 more
core   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Transthyretin mutation and cardiac amyloidosis

, 2022
a novel transthyretin mutation D39Y in a cardiac amyloidosis patient and its biochemical characterizations.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
张, 宁 (via Mendeley Data), 张, 宁
core   +1 more source

Carpal tunnel transthyretin amyloidosis case report comparing MRI findings with amyloid negative control

Discover Medicine
Amyloidosis is a systemic disorder characterized by extracellular protein deposition, with transthyretin amyloidosis being the most common subtype. Carpal tunnel syndrome is a frequent early manifestation, yet detailed MRI characterization of amyloid ...
Jean Pierre Abdallah, Marcus Saldanha, Margherita Leo, Mathieu Boily, Michael Chetrit   +4 more
doaj   +1 more source

Old disease, new twist

Journal of Hospital Medicine, EarlyView.
Abstract An 81‐year‐old man with a history of high‐grade urothelial carcinoma of the bladder and ureter on treatment with atezolizumab and tiragolumab presented to the emergency department with 5 months of malaise, generalized weakness, and fatigue and 2 weeks of subjective fevers. One month prior to presentation, he received an empiric 9‐day course of
Hadi Roudsari, Gurpreet Dhaliwal, Anand D. Jagannath, Alan H. Baik, Sam Brondfield   +4 more
wiley   +1 more source

Treatment of Acquired Transthyretin Amyloidosis in Domino Liver Transplantation [PDF]

, 2022
BACKGROUND: Domino liver transplantation (DLT) has been commonly used during the last two decades to partly meet the high need for liver transplants.
Konstantinos I. Tsamis, Sarmas, Ioannis, Gillmore, Julian D, Michael Heneghan, Julian D. Gillmore, Spyridon Konitsiotis, Giannopoulos, Sotirios, Mytilinaios, Dimitrios, Ioannis Sarmas, Dimitrios Mytilinaios, Janet A. Gilbertson, Tsamis, Konstantinos I, Gilbertson, Janet A, Heneghan, Michael, Konitsiotis, Spyridon, Sotirios Giannopoulos   +15 more
core   +1 more source

Protein mis-folding and human disease

, 2010
Serum Amyloid P Component (SAP), a putative molecular chaperone, is a homopentamericplasma protein of 25kDa subunits. It binds to the amyloid fibrils ofmisfolded proteins, which cause amyloidosis in humans. SAP not only stabilizesamyloid fibrils but also
Pal, Mohinder
core   +1 more source