Results 71 to 80 of about 44,633 (211)

Negative for AL and ATTR: Could It Still Be Amyloid?

Annals of Internal Medicine: Clinical Cases
Amyloidosis is a systemic disease characterized by the extracellular deposition of misfolded proteins. We present a rare case of familial amyloidosis with multiorgan involvement.
Ahmed B. Elawad, Paul Wilkinson, Ryan Kimball, Ahmed F. Abdulrahim   +3 more
doaj   +1 more source

Excisional goniotomy with Kahook Dual Blade in a patient with glaucoma secondary to Transthyretin Amyloidosis

American Journal of Ophthalmology Case Reports, 2020
Purpose: To report for the first time the successful use of the Kahook Dual Blade excisional goniotomy technique in a patient with Transthyretin Amyloidosis. Patient and methods: The Kahook Dual Blade is a single use ab interno trabeculectomy device that
Natalie Brossard Barbosa, Tomas M. Grippo   +1 more
doaj   +1 more source

A Case of Systemic Amyloidosis Diagnosed After Excision of a Cutaneous Tumour of the Buttocks

JEADV Clinical Practice, EarlyView.
ABSTRACT A 72‐year‐old Japanese man was referred to our hospital with two tumours on the buttocks. Two solitary, 2.5 × 1.5 cm‐sized, dark brown, well‐demarcated elevated plaques were observed, one on each side of the gluteal cleft, and dermoscopic examination showed comedo‐like openings, multiple milia‐like cysts, and a cerebriform pattern with ...
Tomomichi Shimizu, Hinako Chiba, Shinpei Hamasaki, Sho Arai, Tomomi Inomata, Ayako Hirota, Akio Kondo, Fumikazu Yamazaki, Yohei Masugi, Tomotaka Mabuchi   +9 more
wiley   +1 more source

Gateway and journey of patients with cardiac amyloidosis

ESC Heart Failure, 2020
Aims Advances have been made over the last decade in the management of cardiac amyloidosis (CA), but a delayed diagnosis is still common. The aim of this study was to describe the journey to CA diagnosis from initial clinical and to analyse time to ...
Daniel Dang, Pauline Fournier, Eve Cariou, Antoine Huart, David Ribes, Pascal Cintas, Murielle Roussel, Magali Colombat, Yoan Lavie‐Badie, Didier Carrié, Michel Galinier, Olivier Lairez   +11 more
doaj   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Specific therapeutic options for transthyretin amyloidosis

The epidemiology of systemic amyloidosis has recently undergone a spectacular transformation. While light-chain amyloidosis remains a rare disease with a stable incidence, chronic inflammatory disease associated amyloidosis (AA) is diagnosed less ...
Zoltán Pozsonyi
core   +1 more source

Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis

JACC: Basic to Translational Science
Summary: Amyloid transthyretin cardiac amyloidosis is one of the most common infiltrative cardiomyopathies. Contractile, biochemical, and histological assays were performed on myocardium from patients with and without amyloid transthyretin amyloidosis ...
Gregory N. Milburn, BS, Jania Bell, BS, Austin G. Wellette-Hunsucker, MS, Hollings Ruml, Andrew T. Yackzan, MS, Kenneth S. Campbell, PhD   +5 more
doaj   +1 more source

Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis

The FEBS Journal, EarlyView.
In this study, we investigate how flow constrictions and shear stress trigger cardiac antibody light chain (AL) fibril formation and deposition. We mimic the mechanical forces exerted by the heart and the microvasculature network using a mini‐peristaltic pump setup and a grid‐type microchannel network, respectively.
Yuji Goto, Keiichi Yamaguchi, Kichitaro Nakajima, Ikuko Yumen, Ruiming He, Hirokazu Matsuda, Tetsuichi Wazawa, Takeharu Nagai, Nobuhiro Tsukada, Suguru Yamamoto, Johannes Buchner, Hirotsugu Ogi   +11 more
wiley   +1 more source

Systemic Transthyretin Amyloidosis With Concomitant Cardiopulmonary Involvement: A Case Report

Annals of Internal Medicine: Clinical Cases
Systemic amyloidosis is an uncommon disease that includes light chain and transthyretin amyloidosis. In the early years, cardiopulmonary systemic amyloidosis had poor outcomes attributable to delayed diagnosis.
Sumukh Arun Kumar, Kannu Bansal, Chidambaram Ramasamy, Sushmita Prabhu, George M. Abraham   +4 more
doaj   +1 more source

Role of FibroScan in evaluating hepatic involvement in systemic amyloidosis: a single‐centre prospective pilot study

Internal Medicine Journal, EarlyView.
Abstract Background Amyloidosis encompasses a group of diseases characterised by extracellular deposition of misfolded protein fibrils, potentially leading to organ dysfunction. Liver involvement occurs via direct amyloid infiltration, common in immunoglobulin light chain (AL) amyloidosis, or congestive hepatopathy, more typical in transthyretin (ATTR)
M Tang, N Vootukuru, J Tjahyadi, D Clayton Chubb, H Jina, SB Ting, S Bloom, R Sawhney, S Gibbs, O. Niewiadomski   +9 more
wiley   +1 more source