Results 71 to 80 of about 16,120 (219)

Systemic Transthyretin Amyloidosis Incidentally Diagnosed With Prostate Biopsy: A Case Report

IJU Case Reports
Introduction The diagnosis of systemic transthyretin amyloidosis based on prostate biopsy is very rare, and we report this case with a literature review.
Michihide Nakamura, Shinnosuke Kuroda, Takashi Kawahara, Erika Muraoka, Genya Iwamoto, Kota Shimokihara, Takeaki Noguchi, Masanobu Yamazaki, Akihito Hashizume, Daiji Takamoto, Rie Horii, Satoshi Fujii, Miki Tanoshima, Junichi Teranishi, Hiroji Uemura   +14 more
doaj   +1 more source

Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis

JACC: Basic to Translational Science
Summary: Amyloid transthyretin cardiac amyloidosis is one of the most common infiltrative cardiomyopathies. Contractile, biochemical, and histological assays were performed on myocardium from patients with and without amyloid transthyretin amyloidosis ...
Gregory N. Milburn, BS, Jania Bell, BS, Austin G. Wellette-Hunsucker, MS, Hollings Ruml, Andrew T. Yackzan, MS, Kenneth S. Campbell, PhD   +5 more
doaj   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

The transthyretin cDNA sequence is normal in transthyretin-derived senile systemic amyloidosis

, 1991
A variety of mutations leading to amino acid substitutions have been described in the transthyretin gene in association with different familial amyloidoses and have been implicated to be involved in the pathogenesis of amyloid deposits.
Gustavsson, Å., Betsholtz, C., L. Christmanson, Johansson, B., Sletten, K., Westermark, P., B. Johansson, K. Sletten, Christmanson, L., C. Betsholtz, Å. Gustavsson, P. Westermark   +11 more
core   +1 more source

Systemic Transthyretin Amyloidosis With Concomitant Cardiopulmonary Involvement: A Case Report

Annals of Internal Medicine: Clinical Cases
Systemic amyloidosis is an uncommon disease that includes light chain and transthyretin amyloidosis. In the early years, cardiopulmonary systemic amyloidosis had poor outcomes attributable to delayed diagnosis.
Sumukh Arun Kumar, Kannu Bansal, Chidambaram Ramasamy, Sushmita Prabhu, George M. Abraham   +4 more
doaj   +1 more source

Utilization and Prognosis of Cardiac Device Implantation in AL Versus ATTR Amyloidosis

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Introduction Cardiac amyloidosis can cause congestive heart failure, arrhythmias, and heart blocks, which frequently require cardiac device implantation (CDI). However, the differences between light chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis CDI requirements are unknown. Methods A retrospective analysis was conducted using the
Bilal Hussain, Sanchit Duhan, Khawaja Hassan Akhtar, Amith Reddy Seri, Krittapoom Akrawinthawong, Janardhana Gorthi, Bijeta Keisham, Tarun Dasari   +7 more
wiley   +1 more source

Hereditary and acquired transthyretin-mediated amyloidosis [PDF]

, 2020
We describe three cases, two 70-year-old males with mainly cardiac symptoms and a 34-year-old male with gastro-intestinal and neurologic symptoms. Each patient was shown to have a distinctive type of transthyretin-mediated amyloidosis (ATTR).
Hazenberg, Bouke P C, van der Bie, Maarten H, van Daele, Paul L A, Hazenberg, Bouke P C; id_orcid, Boots, J M M, Klaassen, Sebastiaan H C, Louter, Leonora   +6 more
core   +2 more sources

Testing the utility of the first step of system evaluation theory in creating a system map of care for cardiac amyloidosis early detection: A case study.

PLoS ONE
BackgroundHeart failure is a clinical syndrome resulting from numerous pathological conditions. One cause of heart failure, transthyretin cardiac amyloidosis, presents insidiously with common and seemingly unrelated symptoms.
Sherry L Ball, Alexis Koskan, Jenice Guzman, Sandesh Dev   +3 more
doaj   +1 more source

Age- and Sex-Related Differences in Patients With Wild-Type Transthyretin Amyloidosis

JACC: Advances
Background: Wild-type transthyretin amyloidosis (ATTRwt amyloidosis) is primarily diagnosed in elderly men but diagnoses in younger patients and women have recently increased.
Nerea Mora-Ayestaran, MD, Angela Dispenzieri, MD, Arnt V. Kristen, MD, Mathew S. Maurer, MD, Igor Diemberger, MD, Brian M. Drachman, MD, Martha Grogan, MD, Pritam Gupta, PhD, Oliver Glass, PhD, Leslie Amass, PhD, Pablo Garcia-Pavia, MD, PhD, Michele Emdin, Mazen Hanna, Olga Azevedo, Calogero Lino Cirami, Jose Gonzalez Costello, David Slosky, Henning Moelgaard, Jose Nativi Nicolau, Scott Hummel, Eun-Seok Jeon, Nowell Fine, Srinivas Murali, Edward Miller, Sanjiv Shah, Ronald Witteles, Marcia Waddington-Cruz, Daniel Lenihan, Yoshiki Sekijima, Johan Van Cleemput, Edileide de Barros Correia, Eve Cariou, Dianna Quan, Miriam Freimer, David Steidley, Anna Hüsing-Kabar, Violaine Plante-Bordeneuve, Hans Nienhuis, Jonas Wixner, Jeffrey Ralph, Hector Ventura, Sasa Zivkovic, Diego Delgado, Roberto Fernandéz Torrón, Stephen Gottlieb, William Cotts, Jose Tallaj, Robert Brunkhorst, Michael Polydefkis, Christopher Mueller, Carsten Tschoepe, Juan Gonzalez Moreno, Nitasha Sarswat, Jin Luo, James Tauras, Alberta Warner   +55 more
doaj   +1 more source

Localized Gastrointestinal Light Chain (AL) Amyloidosis Under Surveillance for Five Years: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Amyloidosis, characterized by the deposition of abnormal protein fibrils in organs, is classified as systemic or localized. Amyloid light chain (AL)‐type localized amyloidosis is uncommon, particularly when confined to the gastrointestinal tract.
Shunsuke Kojimahara, Keiichi Tominaga, Akira Yamamiya, Mimari Kanazawa, Takanao Tanaka, Takeshi Sugaya, Nagaaki Katoh, Atsushi Irisawa   +7 more
wiley   +1 more source