Results 81 to 90 of about 44,633 (211)

Testing the utility of the first step of system evaluation theory in creating a system map of care for cardiac amyloidosis early detection: A case study.

PLoS ONE
BackgroundHeart failure is a clinical syndrome resulting from numerous pathological conditions. One cause of heart failure, transthyretin cardiac amyloidosis, presents insidiously with common and seemingly unrelated symptoms.
Sherry L Ball, Alexis Koskan, Jenice Guzman, Sandesh Dev   +3 more
doaj   +1 more source

Pathophysiology and Comprehensive Pharmacological Management of ATTR Cardiac Amyloidosis: Knowledge Gaps, Ongoing Clinical Trials, and Future Research Directions

Pharmaceuticals
The purpose of this review article is to discuss the current treatment modalities and ongoing clinical trials regarding cardiac amyloidosis (CA), specifically transthyretin cardiac amyloidosis (ATTR-CA). Amyloidosis refers to the extracellular deposition
Sareen Bains, Harry Atwal, Ashbir Sidhu, Harpreet Singh, Gurpreet Sodhi   +4 more
doaj   +1 more source

Feasibility, Safety, and Efficacy of Pulsed Field Ablation for Ventricular Arrhythmias: Insights From a Large Health System Registry in the United States

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Pulsed field ablation (PFA) is an emerging non‐thermal ablation modality with proven safety in atrial arrhythmia ablation. However, data on its performance for ventricular arrhythmias (VA) remain limited. Objective To evaluate the feasibility, safety, and efficacy of PFA for complex VA in a multicenter real‐world US registry ...
Narut Prasitlumkum, Juan F. Rodriguez‐Riascos, Hema Vemulapalli, Aakash Somappa, Camilo A. Estrada‐Vargas, Olubadewa A. Fatunde, Carlos A. Rojas, Poojan Prajapati, Keerthika Vijayakumar, Suraj Kapa, Duy Nguyen, Samuel Asirvatham, Malini Madhavan, Christopher McLeod, Hicham Z. El Masry, Abhishek J. Deshmukh, Danesh K. Kella, Ammar M. Killu, Siva K. Mulpuru, Mayank Sardana, Luis R. Scott, Alan M. Sugrue, Komandoor Srivathsan   +22 more
wiley   +1 more source

Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis [PDF]

Circulation, 2016
Background— Cardiac transthyretin (ATTR) amyloidosis is a progressive and fatal cardiomyopathy for which several promising therapies are in development. The diagnosis is frequently delayed or missed because of the limited specificity of echocardiography and the traditional requirement for histological ...
Gillmore, Julian D, Maurer, Mathew S., Falk, Rodney H., Merlini, Giampaolo, Damy, Thibaud, Dispenzieri, Angela, Wechalekar, Ashutosh D., Berk, John L., QUARTA, CANDIDA CRISTINA, Grogan, Martha, Lachmann, Helen J., Bokhari, Sabahat, Castano, Adam, Dorbala, Sharmila, Johnson, Geoff B., Glaudemans, Andor W. J. M., Rezk, Tamer, Fontana, Marianna, Palladini, Giovanni, Milani, Paolo, Guidalotti, Pierluigi L., Flatman, Katarina, Lane, Thirusha, Vonberg, Frederick W., Whelan, Carol J., Moon, James C., Ruberg, Frederick L., Miller, Edward J., Hutt, David F., Hazenberg, Bouke P., RAPEZZI, CLAUDIO, Hawkins, Philip N.   +31 more
openaire   +6 more sources

Age- and Sex-Related Differences in Patients With Wild-Type Transthyretin Amyloidosis

JACC: Advances
Background: Wild-type transthyretin amyloidosis (ATTRwt amyloidosis) is primarily diagnosed in elderly men but diagnoses in younger patients and women have recently increased.
Nerea Mora-Ayestaran, MD, Angela Dispenzieri, MD, Arnt V. Kristen, MD, Mathew S. Maurer, MD, Igor Diemberger, MD, Brian M. Drachman, MD, Martha Grogan, MD, Pritam Gupta, PhD, Oliver Glass, PhD, Leslie Amass, PhD, Pablo Garcia-Pavia, MD, PhD, Michele Emdin, Mazen Hanna, Olga Azevedo, Calogero Lino Cirami, Jose Gonzalez Costello, David Slosky, Henning Moelgaard, Jose Nativi Nicolau, Scott Hummel, Eun-Seok Jeon, Nowell Fine, Srinivas Murali, Edward Miller, Sanjiv Shah, Ronald Witteles, Marcia Waddington-Cruz, Daniel Lenihan, Yoshiki Sekijima, Johan Van Cleemput, Edileide de Barros Correia, Eve Cariou, Dianna Quan, Miriam Freimer, David Steidley, Anna Hüsing-Kabar, Violaine Plante-Bordeneuve, Hans Nienhuis, Jonas Wixner, Jeffrey Ralph, Hector Ventura, Sasa Zivkovic, Diego Delgado, Roberto Fernandéz Torrón, Stephen Gottlieb, William Cotts, Jose Tallaj, Robert Brunkhorst, Michael Polydefkis, Christopher Mueller, Carsten Tschoepe, Juan Gonzalez Moreno, Nitasha Sarswat, Jin Luo, James Tauras, Alberta Warner   +55 more
doaj   +1 more source

Localized Gastrointestinal Light Chain (AL) Amyloidosis Under Surveillance for Five Years: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Amyloidosis, characterized by the deposition of abnormal protein fibrils in organs, is classified as systemic or localized. Amyloid light chain (AL)‐type localized amyloidosis is uncommon, particularly when confined to the gastrointestinal tract.
Shunsuke Kojimahara, Keiichi Tominaga, Akira Yamamiya, Mimari Kanazawa, Takanao Tanaka, Takeshi Sugaya, Nagaaki Katoh, Atsushi Irisawa   +7 more
wiley   +1 more source

Eprodisate for the treatment of renal disease in AA amyloidosis [PDF]

, 2007
Background: Amyloid A (AA) amyloidosis is a complication of chronic inflammatory conditions that develops when proteolytic fragments of serum amyloid A protein (SAA) are deposited in tissues as amyloid fibrils.
Dember, L.M., Hazenberg, B.P.C., Garceau, D., Puéchal, X., Livneh, A., Lesnyak, O., Skinner, Martha, Lesnyak, Olga, Livneh, Avi, Butrimiene, I., Merlini, G., Hauck, Wendy, Obici, L., Dember, Laura M., Gorevic, Peter D., Skinner, M., Butrimiene, Irena, Hawkins, Philip N., Balshaw, Robert, Hazenberg, Bouke P. C.; id_orcid, Lachmann, Helen J., Obici, Laura, Gorevic, P.D., Puechal, Xavier, Hazenberg, Bouke P. C., Hawkins, P.N., Garceau, Denis, Balshaw, R., Lachmann, H.J., Merlini, Giampaolo, Hauck, W.   +30 more
core  

Characteristics of Patients with Late- vs. Early-Onset Val30Met Transthyretin Amyloidosis from the Transthyretin Amyloidosis Outcomes Survey (THAOS)

, 2021
Introduction: Hereditary transthyretin amyloidosis (ATTRv amyloidosis) is a clinically heterogeneous disease caused by mutations in the transthyretin (TTR) gene. The most common mutation, Val30Met, can manifest as an early- or late-onset disease. Methods:
Ando, Yukio, Waddington-Cruz, Márcia, Waddington-Cruz, Márcia,, Amass, Leslie, Waddington Cruz, Marcia, Chapman, Doug, Chapman, Doug,, Wixner, Jonas,, Wixner, Jonas, Kiszko, Jan,, Amass, Leslie,, Kiszko, Jan, THAOS investigators, Ando, Yukio,, Daniel Lenihan, Theodoros Kyriakides, Roberto Fernandéz Torrón, Leslie Amass, Angela Dispenzieri, Annabel Wang, Felix Darstein, Yesim Parman, Brian Drachman, Sasa Zivkovic, Doug Chapman, Marcelo Rugiero, David Adams, Stephen Gottlieb, Pablo Garcia Pavia, null null, Burkhard Gess, Soon Chai Low, Taro Yamashita, Olivier Lairez, Isabel Conceição, Márcia Waddington-Cruz, Marco Luigetti, Juan Gonzalez Moreno, Claudio Rapezzi, Violaine Planté-Bordeneuve, Mathew Maurer, Teresa Coelho, Yoshiki Sekijima, Ivaylo Tarnev, Jonas Wixner, Rayomand Press, Fabio Adrian Barroso, Arnt Kristen, Hans Nienhuis, Yukio Ando, Hartmut Schmidt, Josep Maria Campistol Plana, Giampaolo Merlini, Jose Gonzalez Costello, Francisco Munoz Beamud, Sonoko Misawa, Jan Kiszko, Johan Van Cleemput   +57 more
core   +1 more source

Systemic Amyloidosis with Cardiac Involvement: Features of Course and Diagnostic Difficulties

Архивъ внутренней медицины
The diversity of clinical forms of amyloidosis is related to differences in amyloidogenic precursor proteins. Cardiac involvement is characteristic of AL- and ATTR-amyloidosis, with cardiac involvement developing in the vast majority of patients with AL ...
E. V. Voloshinova, I. Yu. Khorkina, A. M. Dzuban, E. V. Yakovleva   +3 more
doaj   +1 more source

Physical stability of RNA–lipid nanoparticles under agitation, freeze–thaw and accelerated stability testing

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 11, Page 2293-2300, November 2026.
Abstract BACKGROUND The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in RNA delivery where the ability to survive unplanned excursions to higher and lower temperature and vibration is an important attribute.
Franz W Laurett Veras, Leah Wright, Robert J Falconer   +2 more
wiley   +1 more source