Results 81 to 90 of about 16,120 (219)

Outcomes of Patients With Familial Transthyretin Amyloidosis After Liver Transplantation

, 2017
Background: Familial transthyretin amyloidosis is a disease caused by misfolded transthyretin aggregates that can impair multiple organ systems. Liver transplantation is the first-line treatment for familial transthyretin amyloidosis.
Martha Grogan, Julie Heimbach, Paul Swiecicki, Angela Dispenzieri, Lindsey E. Roeker, Morie Gertz, Brooks Edwards, Steve Zeldenrust, Richard Daly, John Poterucha, Kyle W. Klarich, Dipti Banerjee   +11 more
core   +1 more source

Systemic Amyloidosis with Cardiac Involvement: Features of Course and Diagnostic Difficulties

Архивъ внутренней медицины
The diversity of clinical forms of amyloidosis is related to differences in amyloidogenic precursor proteins. Cardiac involvement is characteristic of AL- and ATTR-amyloidosis, with cardiac involvement developing in the vast majority of patients with AL ...
E. V. Voloshinova, I. Yu. Khorkina, A. M. Dzuban, E. V. Yakovleva   +3 more
doaj   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Specific therapeutic options for transthyretin amyloidosis

The epidemiology of systemic amyloidosis has recently undergone a spectacular transformation. While light-chain amyloidosis remains a rare disease with a stable incidence, chronic inflammatory disease associated amyloidosis (AA) is diagnosed less ...
Zoltán Pozsonyi
core   +1 more source

Concurrent Tongue and Cervical Lymph Node Amyloidosis Without Systemic Disease

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Amyloidosis of the head and neck is often associated with systemic involvement. However, this report describes a rare presentation of localized amyloidosis involving both the tongue and cervical lymph nodes in a patient without systemic disease.
Chelsea O. Onyeji, Alycia M. Boutrand, Lewis Overton   +2 more
wiley   +1 more source

Historic characteristics and mortality of patients in the Swiss Amyloidosis Registry

Swiss Medical Weekly
AIMS OF THE STUDY: Systemic amyloidoses are rare protein-folding diseases with heterogeneous, often nonspecific clinical presentations. To better understand systemic amyloidoses and to apply state-of-the-art diagnostic pathways and treatment, the ...
Sofie Brouwers, Raphael Heimgartner, Natallia Laptseva, Adriano Aguzzi, Niklas F. Ehl, Thomas Fehr, Felicitas Hitz, Hans H. Jung, Joel Kälin, Markus G. Manz, Beat Müllhaupt, Frank Ruschitzka, Harald Seeger, Georg Stussi, Markus Zweier, Andreas J. Flammer, Bernhard Gerber, Rahel Schwotzer   +17 more
doaj   +1 more source

The Effect of Protein Tagging on Aggregation and Phase Separation

Journal of Cellular Biochemistry, Volume 127, Issue 6, June 2026.
ABSTRACT Protein tags are widely used for purification, solubilization, detection, and imaging, yet they can substantially alter protein self‐assembly. This interference is particularly significant for intrinsically disordered proteins and low‐complexity domains, whose aggregation and phase separation are mediated by weak multivalent interactions that ...
Harunobu Saito, Kenji Sugase
wiley   +1 more source

A pilot qualitative study of patient understanding and perceptions of genetic counselors and cascade testing in the context of transthyretin cardiac amyloidosis

Journal of Genetic Counseling, Volume 35, Issue 3, June 2026.
Abstract Genetics‐informed care is becoming increasingly important in the management of cardiomyopathy (CM). Despite current guidelines recommending genetic testing and counselors, these services are vastly underutilized. To our knowledge, this is the first qualitative study to examine patient perspectives (n = 10) on genetic counselors and cascade ...
Quan M. Bui, Taylor Berninger, Ana Morales, Lauren Korty, Larry A. Allen, Eric D. Adler, Marcus A. Urey, Kimberly N. Hong, Borsika Rabin, Cinnamon Bloss   +9 more
wiley   +1 more source

Systemic Amyloidosis – Insights by Cardiovascular Magnetic Resonance

, 2015
Systemic amyloidosis is the exemplar infiltrative, extracellular disease. Although it is a multi-organ disorder, cardiac involvement drives prognosis. Survival is worst in the AL amyloidosis subtype. It can affect any age and any race. There is no direct
Banypersad, SM
core  

Technetium-99m pyrophosphate cardiac SPECT in endomyocardial biopsy negative cardiac amyloidosis

Radiology Case Reports, 2018
Cardiac amyloidosis is an under-appreciated cause of heart failure. Establishing a diagnosis is important because traditional heart failure treatment regimens can worsen left ventricular failure in this disease. Endomyocardial biopsy is the gold standard
Martin Krupa, MD, Rina Nguyen, BS, Jonathan Revels, DO, Lester S. Johnson, MD, PhD, FACR   +3 more
doaj   +1 more source