Results 81 to 90 of about 21,545 (230)

Systemic Transthyretin Amyloidosis With Concomitant Cardiopulmonary Involvement: A Case Report

Annals of Internal Medicine: Clinical Cases
Systemic amyloidosis is an uncommon disease that includes light chain and transthyretin amyloidosis. In the early years, cardiopulmonary systemic amyloidosis had poor outcomes attributable to delayed diagnosis.
Sumukh Arun Kumar, Kannu Bansal, Chidambaram Ramasamy, Sushmita Prabhu, George M. Abraham   +4 more
doaj   +1 more source

Renal apolipoprotein A-I amyloidosis: a rare and usually ignored cause of hereditary tubulointerstitial nephritis [PDF]

, 2005
12openopenGregorini G; Izzi C; Obici L; Tardanico R; Röcken C; Viola BF; Capistrano M; Donadei S; Biasi L; Scalvini T; Merlini G; Scolari F.Gregorini, G; Izzi, C; Obici, L; Tardanico, R; Röcken, C; Viola, Bf; Capistrano, M; Donadei, S; Biasi, L; Scalvini,
BIASI, LUIGI, CAPISTRANO M., DONADEI S., GREGORINI G., IZZI C., MERLINI, GIAMPAOLO, OBICI L., ROCKEN C., SCALVINI T., SCOLARI F., TARDANICO R., VIOLA B. F.   +11 more
core   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Hereditary transthyretin amyloidosis (ATTRv)

Current Problems in Cardiology
Hereditary transthyretin (TTR) amyloidosis (ATTRv amyloidosis) is a devastating disease characterized by broad range of clinical manifestations, including predominantly neurological, predominantly cardiac, and mixed phenotypes. This wide phenotypic variability hindered timely disease diagnosis and risk stratification in the past, especially in ...
Filippos Triposkiadis, Alexandros Briasoulis, Randall C. Starling, Dimitrios E. Magouliotis, Christos Kourek, George E Zakynthinos, Efstathios K. Iliodromitis, Ioannis Paraskevaidis, Andrew Xanthopoulos   +8 more
openaire   +3 more sources

Age- and Sex-Related Differences in Patients With Wild-Type Transthyretin Amyloidosis

JACC: Advances
Background: Wild-type transthyretin amyloidosis (ATTRwt amyloidosis) is primarily diagnosed in elderly men but diagnoses in younger patients and women have recently increased.
Nerea Mora-Ayestaran, MD, Angela Dispenzieri, MD, Arnt V. Kristen, MD, Mathew S. Maurer, MD, Igor Diemberger, MD, Brian M. Drachman, MD, Martha Grogan, MD, Pritam Gupta, PhD, Oliver Glass, PhD, Leslie Amass, PhD, Pablo Garcia-Pavia, MD, PhD, Michele Emdin, Mazen Hanna, Olga Azevedo, Calogero Lino Cirami, Jose Gonzalez Costello, David Slosky, Henning Moelgaard, Jose Nativi Nicolau, Scott Hummel, Eun-Seok Jeon, Nowell Fine, Srinivas Murali, Edward Miller, Sanjiv Shah, Ronald Witteles, Marcia Waddington-Cruz, Daniel Lenihan, Yoshiki Sekijima, Johan Van Cleemput, Edileide de Barros Correia, Eve Cariou, Dianna Quan, Miriam Freimer, David Steidley, Anna Hüsing-Kabar, Violaine Plante-Bordeneuve, Hans Nienhuis, Jonas Wixner, Jeffrey Ralph, Hector Ventura, Sasa Zivkovic, Diego Delgado, Roberto Fernandéz Torrón, Stephen Gottlieb, William Cotts, Jose Tallaj, Robert Brunkhorst, Michael Polydefkis, Christopher Mueller, Carsten Tschoepe, Juan Gonzalez Moreno, Nitasha Sarswat, Jin Luo, James Tauras, Alberta Warner   +55 more
doaj   +1 more source

Extracardiac 18F-florbetapir imaging in patients with systemic amyloidosis: more than hearts and minds [PDF]

, 2018
PURPOSE: 18F-Florbetapir has been reported to show cardiac uptake in patients with systemic light-chain amyloidosis (AL). This study systematically assessed uptake of 18F-florbetapir in patients with proven systemic amyloidosis at sites outside the heart.
Burniston, M, Hawkins, PN, Manwani, R, McCool, D, Page, J, Ross, JC, Skillen, A, Wagner, T, Wechalekar, AD   +8 more
core   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Systemic Amyloidosis with Cardiac Involvement: Features of Course and Diagnostic Difficulties

Архивъ внутренней медицины
The diversity of clinical forms of amyloidosis is related to differences in amyloidogenic precursor proteins. Cardiac involvement is characteristic of AL- and ATTR-amyloidosis, with cardiac involvement developing in the vast majority of patients with AL ...
E. V. Voloshinova, I. Yu. Khorkina, A. M. Dzuban, E. V. Yakovleva   +3 more
doaj   +1 more source

Extracellular volume quantification by dynamic equilibrium cardiac computed tomography in cardiac amyloidosis. [PDF]

, 2015
Cardiac involvement determines outcome in patients with systemic amyloidosis. There is major unmet need for quantification of cardiac amyloid burden, which is currently only met in part through semi-quantitative bone scintigraphy or Cardiovascular ...
Bandula, S, Fontana, M, Gilbertson, JA, Gillmore, JD, Hawkins, PN, Herrey, AS, Moon, JC, Punwani, S, Taylor, SA, Treibel, TA, White, SK   +10 more
core   +1 more source

Photo‐Catalyzed Labeling of Amyloid Deposits in Human Tissue to Proteotype Amyloidosis Diseases

Aggregate, Volume 7, Issue 3, March 2026.
Amyloid‐ID, a ThT‐like photocatalytic probe, enables proteotyping of amyloid deposits by ROS‐mediated protein labeling. Applied to patient biopsies, amyloid‐ID identifies potential fibrinogen‐derived amyloid in laryngeal amyloidosis, revealing a mechanically sensitive fibrillation mechanism linked to vocal cord friction.
Huan Feng, Fangliang Guo, Yan Wang, Meng You, Qiuxuan Xia, Wang Wan, Di Shen, Kaini Shen, Xin Zhang, Wei Li, Yu Liu   +10 more
wiley   +1 more source