Results 11 to 20 of about 18,308 (133)

Risk factors for low‐risk prostate cancer: A retrospective cohort study within the FinRSPC trial

International Journal of Cancer, EarlyView.
What's New? Overdiagnosis of low‐risk prostate cancer remains an important downside of prostate‐specific antigen‐based screening. This retrospective cohort study of 80,144 men with a median follow‐up of 18.0 years shows that risk factors for low‐risk prostate cancer differ significantly from those for high‐risk prostate cancer.
Uzoamaka E. Okwor, Jani Raitanen, Kirsi Talala, Teuvo L. J. Tammela, Kimmo Taari, Paula Kujala, Anssi Auvinen   +6 more
wiley   +1 more source

Physical activity and risks of recurrence and progression among patients with non‐muscle invasive bladder cancer

International Journal of Cancer, EarlyView.
What's New? High physical activity levels have been linked to a lower cancer recurrence risk in patients with solid tumors, but evidence is lacking for non‐muscle invasive bladder cancer. This prospective observational cohort study found no clear associations between prediagnosis or postdiagnosis physical activity levels and the risk of recurrence or ...
Ivy Beeren, Joann Kiebach, Jasper P. Hof, Laurien M. Buffart, Katja K. H. Aben, J. Alfred Witjes, Antoine G. van der Heijden, Lambertus A. L. M. Kiemeney, Alina Vrieling   +8 more
wiley   +1 more source

TMB‐High, MSI‐High Castration‐Resistant Prostate Cancer Treated With Pembrolizumab

IJU Case Reports, EarlyView.
ABSTRACT Introduction The use of pembrolizumab in patients with microsatellite instability‐high (MSI‐high) and tumor mutation burden‐high (TMB‐high) prostate cancer in Japan is not widely reported. Here, we report the case of a patient with MSI‐high and TMB‐high prostate cancer who responded well to pembrolizumab after multiple systemic treatments ...
Satoshi Muraoka, Hisanobu Tosuji, Yuya Iwahashi, Hiroki Kawabata, Ryusuke Deguchi, Takahito Wakamiya, Shimpei Yamashita, Yasuo Kohjimoto, Isao Hara   +8 more
wiley   +1 more source

A Case of Renal Metastasis of Urothelial Carcinoma With Trophoblastic Differentiation Successfully Treated With Robot‐Assisted Partial Nephrectomy

IJU Case Reports, EarlyView.
ABSTRACT Introduction There are no previous reports of solitary renal metastases from urothelial carcinoma with trophoblastic differentiation, a rare bladder cancer subtype that is pathologically hCGβ positive. Case Presentation A 77‐year‐old male with urothelial carcinoma with trophoblastic differentiation underwent robot‐assisted radical cystectomy ...
Seiichiro Honda, Koichi Uemura, Hiroki Ito, Erika Muraoka, Tomoyuki Tatenuma, Yusuke Ito, Kentaro Muraoka, Hisashi Hasumi, Naomi Kawano, Shoji Yamanaka, Kazuhide Makiyama   +10 more
wiley   +1 more source

Systemic Transthyretin Amyloidosis Incidentally Diagnosed With Prostate Biopsy: A Case Report

IJU Case Reports, EarlyView.
ABSTRACT Introduction The diagnosis of systemic transthyretin amyloidosis based on prostate biopsy is very rare, and we report this case with a literature review. Case Presentation A 73‐year‐old male patient was referred to our department due to an increased serum prostate‐specific antigen level at 10.4 ng/mL while receiving benign prostatic ...
Michihide Nakamura, Shinnosuke Kuroda, Takashi Kawahara, Erika Muraoka, Genya Iwamoto, Kota Shimokihara, Takeaki Noguchi, Masanobu Yamazaki, Akihito Hashizume, Daiji Takamoto, Rie Horii, Satoshi Fujii, Miki Tanoshima, Junichi Teranishi, Hiroji Uemura   +14 more
wiley   +1 more source

Interstitial Cystitis/Bladder Pain Syndrome in Men

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims In April 2025, the Wake Forest Institute for Regenerative Medicine hosted a Global Consensus meeting on interstitial cystitis/bladder pain syndrome (IC/BPS) in Winston‐Salem, NC. The goal of this meeting was to establish attainable targets in phenotyping, diagnosis, and biomarkers for IC/BPS.
Madeline Snipes, Wyatt Whitman, Michel Pontari, Jennifer Anger, Michael Samarinas, Rajesh Taneja   +5 more
wiley   +1 more source

Single‐Cell Sequencing Reveals That CD4+ T Cells Eliminate Senescent Prostate Epithelium to Delay Progression of Benign Prostatic Hyperplasia

Aging Cell, EarlyView.
Senescent BPH epithelial cells secrete CXCL13 to recruit CD4+ T cells via CXCR5. Cytotoxic CD4+ T cells eliminate senescent cells through MHC‐II–dependent recognition. Tregs suppress, while B cells show minimal effect. This immune axis modulates senescent cell clearance and may influence BPH progression.
Zheng Li, Xiaofei Wang, Zhifu Liu, Senmao Li, Zhenan Zhang, Chenchen Huang, Yixiao Liu, Xingxing Tang, Jiaen Zhang, Peimin Zhou, Ying Gan, Yu Fan, Yisen Meng, Kaiwei Yang, Shuai Hu, Qian Zhang, Wei Yu   +16 more
wiley   +1 more source

Recommendation on the use of protective eyewear in endourological laser procedures

BJU International, Volume 135, Issue 4, Page 577-581, April 2025.
Objectives This work examines the current evidence available regarding the risks of eye injury in endourology laser environments with the aim of providing a consensus recommendation on the appropriate use of protective eyewear. Methods A working group was set up consisting of urological surgeons and laser protection advisors.
Tom Lister, Stan Batchelor, Mike Regan, Jason Britton, Hari Ratan, Feras Al‐Jaafari, Jake Patterson, British Medical Laser Association and the British Association of Urological Surgeons Endourology Section   +7 more
wiley   +1 more source

A study of oral metformin for the intravesical treatment of non‐muscle‐invasive bladder cancer

BJU International, EarlyView.
Objectives To evaluate the effect of metformin on non‐muscle‐invasive bladder cancer (NMIBC) marker lesions. Patients and methods A phase II, open‐label, multicentre, marker lesion trial using oral metformin in patients with primary or recurrent, multiple, low‐grade Ta‐T1 NMIBC was conducted. After transurethral resection for histological confirmation,
Jons W. van Hattum, Marinka J. Remmelink, Sieb T. Nuijens, Ben Max de Ruiter, Gerrit K.J. Hooijer, Jorg R. Oddens, C. Dilara Savci‐Heijink, Ron Mathot, J. Alfred Witjes, Michael .N. Pollak, Theo M. de Reijke, Remco J. Molenaar, Hanneke W. Wilmink   +12 more
wiley   +1 more source

Contemporary outcomes in non‐muscle‐invasive bladder cancer: a large European multicentre study

BJU International, EarlyView.
Objective To report real‐world rates of non‐muscle‐invasive bladder cancer (NMIBC) recurrence and progression within a European multicentre cohort with detailed information on intravesical instillation courses, as contemporary data on oncological outcomes in NMIBC are limited.
Mattia Longoni, Pietro Scilipoti, Mario De Angelis, Paolo Zaurito, Giovanni Tremolada, Alfonso Santangelo, Giuseppe Simone, Riccardo Mastroianni, Chiara Lonati, Stefania Zamboni, Nazareno Suardi, Gautier Marcq, Aleksandra Szostek, Jorge Caño Velasco, Alfonso Lafuente Puentedura, José Daniel Subiela, Pedro Del Olmo Durán, Aleksander Ślusarczyk, Pierre I. Karakiewicz, Benjamin Pradere, Francesco Soria, Paolo Gontero, Morgan Rouprêt, Francesco Montorsi, Andrea Salonia, Alberto Briganti, Marco Moschini, the European Association of Urology ‐ Young Academic Urologists (EAU‐YAU), Urothelial Carcinoma Working Group   +28 more
wiley   +1 more source