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The Acceleration of Development of Transversal Competences [PDF]
, 2017 The monograph, made available to the Reader, contains, in the first place, a selection of theoretical issues related to the question of acquiring transversal competences by students. Secondly, it presents the results of the team’s work which will be used
core
Assessment of the transversal competences: analysis and resolution of problems and, planning and time management [PDF]
, 2019 [EN] European universities are in the process of experimenting with teaching by applying the new learning model according to the Bologna plan, based on specific and transversal competences.
David Ribó-Pérez +7 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
SOME EXPERIENCES ON DEVELOPING AND EVALUATING TRANSVERSAL COMPETENCES IN HIGHER EDUCATION [PDF]
, 2018 The Bologna process has driven a student-centered learning which has affected the whole learning/teaching process, with teachers and students both participating a process of cooperative learning in order to develop useful competences.
Lucía Seguí +3 more
core +1 more source
, 2023 Organizations look for new and increasingly global and international business models and increase their relationships with other cultures. Companies are therefore looking for executive profiles that prioritize availability, mobility, and adaptability to ...
Wodociag, Sophie +2 more
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Development of the Transversal Competencies in Learning Factories
Procedia Manufacturing, 2020 Abstract Transversal competencies in engineering education enable the engineering graduates to be competitive and adaptive to address the real world industry needs. Learning factories (LF) are suitable tools for enhancing learning experiences where the core competencies and transversal competencies are applied according to different work related ...
null Devika +5 more
openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source