Results 121 to 130 of about 135,062 (303)
Sustainability and institutionalization model: the case of the MPIA [PDF]
, 2019 The present text deals in a general way the way in which from the Master in Innovative Processes in Learning (MPIA) that operates as a double degree by the Centro Universitario de Los Altos (CUALTOS) of the University of Guadalajara, in collaboration ...
Carranza Alcántar, Maria del Rocío +3 more
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
THE INVESTIGATIVE SKILLS AS A TRANSVERSE AXIS OF THE TRAINING FOR RESEARCH
Tendencias Pedagógicas, 2015 The present revision has the objective of identifying the theoretical and conceptual foundations that allow the formal study of the training and development of research skills as transverse axis of the training for research in undergraduate. The search of the theoretical sources was carried out starting from such approaches as: study of the subject for
Dianelkys Martínez Rodríguez +1 more
openaire +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Promoting excellence in employability and transversal skills (PEETS)
, 2021 The primary aim of this chapter is to share our journey from a working group of like-minded individuals into a high-performing team. We will focus on the key components of our unique, multi-award winning Promoting Excellence in Employability and Transversal Skills (PEETS) initiative that created inspirational and transformative learning activities. The
Gilmour, Bob +6 more
openaire +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Transversal Skills in the World of Work: Applied Linguistics’ Approach
Baltic Journal of English Language, Literature and Culture, 2017 As a result of the ethno-cultural and economic contacts taking place between different countries, the 21st century has set new guidelines, known as transversal or soft skills, for employability worldwide.
Indra Karapetjana +5 more
doaj