Results 11 to 20 of about 4,928 (175)

Sensitization of Non-M3 Acute Myeloid Leukemia Blasts to All-Trans Retinoic Acid by the LSD1 Inhibitor Tranylcypromine: TRANSATRA Phase I Study. [PDF]

Eur J Haematol
ABSTRACT The treatment of elderly, nonfit acute myeloid leukemia (AML)/MDS patients with relapsed/refractory (R/R) disease remains challenging. As histone demethylase LSD1 (KDM1A) is a rational therapeutic target in AML, we conducted a phase I trial (“rolling‐six design”) with the LSD1 inhibitor tranylcypromine (TCP, dose levels [DL] 20, 40, 60, 80 mg ...
Kruszewski M, Schmoor C, Berg T, Rehman UU, Schittenhelm M, Götze K, Kündgen A, Pabst C, Ma T, Frey A, Stomper J, Pfeifer D, Metzger E, Jung J, Moschallski K, Thomas J, Bug G, Duyster J, Jung M, Schüle R, Wäsch R, Grishina O, Lübbert M.   +22 more
europepmc   +4 more sources

Unravelling the target landscape of tranylcypromines for new drug discovery

Acta Pharmaceutica Sinica B
Molecular editing around privileged scaffolds, also known as periphery editing, is a commonly used strategy in contemporary drug discovery and development.
Yihui Song, Junbiao Chang, Bin Yu
doaj   +2 more sources

NLRP3 inflammasome and hearing loss: from mechanisms to therapies [PDF]

Journal of Neuroinflammation
The NLRP3 inflammasome, a key component of the innate immune system, has emerged as a central mediator of inflammation-driven sensorineural hearing loss (SNHL).
Silvia Murillo-Cuesta, Elena Seoane, Blanca Cervantes, Jose Manuel Zubeldia, Isabel Varela-Nieto   +4 more
doaj   +2 more sources

A Machine-Learning Approach Identifies Rejuvenating Interventions in the Human Brain. [PDF]

Adv Sci (Weinh)
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Santamaria G, Iglesias C, Jung S, Arcos Hodar J, Nogueiras R, Del Sol A.   +5 more
europepmc   +2 more sources

Tranylcypromine and Convulsions [PDF]

BMJ, 1963
H. H. Pilling
openaire   +4 more sources

LSD1 Inhibition Enhances the Immunogenicity of Mesenchymal Stromal Cells by Eliciting a dsRNA Stress Response

Cells, 2022
Mesenchymal stromal cells (MSCs) are commonly known for their immune-suppressive abilities. However, our group provided evidence that it is possible to convert MSCs into potent antigen presenting cells (APCs) using either genetic engineering or ...
Fatemeh Mardani, Wael Saad, Nehme El-Hachem, Jean-Pierre Bikorimana, Mazen Kurdi, Riam Shammaa, Sebastien Talbot, Moutih Rafei   +7 more
doaj   +1 more source

National Prescribing Trends and Cost Analysis of Antidepressants, Anxiolytics, and Hypnotics in England, 2010-2023. [PDF]

Hum Psychopharmacol
ABSTRACT Introduction We describe prescribing of anxiolytics/hypnotics/antidepressants at an all‐England level between 2010 and 2023, taking account of the influence of the COVID‐19 pandemic‐period. Methods All Primary Care Prescribing data for England for anxiolytics/hypnotics/antidepressant agents taken as tablets or capsules from 1 January 2010 to ...
Stedman M, Davies M, Levy JW, Ingram J, Taylor D, Heald A.   +5 more
europepmc   +2 more sources

Evolution of ideas about the risk of tyramine syndrome developing during therapy with irreversible non-selective monoamine oxidase inhibitors (to the 70th anniversary of the first use of this group of antidepressants)

Неврология, нейропсихиатрия, психосоматика, 2022
We describe the history of studying of the problem of tyramine syndrome during the treatment with antidepressants, irreversible non-selective monoamine oxidase inhibitors. Data on clinical observations are presented.
D. S. Danilov, M. Yu. Brovko
doaj   +1 more source

The History of Irreversible Non-Selective MAOI Antidepressants in Russia (for their 70th Anniversary)

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2023
The history of irreversible non-selective MAOI antidepressants in the USSR and Russia is systemized. The history of representatives’ appearance is described. The history of the study of pharmacological effects is highlighted.
D. S. Danilov
doaj   +1 more source

Altered states, alkaloids, and catatonia: Monoaminoxidase inhibitors and their role in the history of psychopharmacology

Frontiers in Pharmacology, 2022
Monoamine oxidases are mitochondrial enzymes that catalyze the oxidative deamination of biogenic amines (adrenaline, noradrenaline, serotonin, and dopamine), causing their inactivation and subsequently playing a fundamental role in the homeostasis of ...
Octavian Buda, Sorin Hostiuc, Ovidiu Popa-Velea, Steluta Boroghina   +3 more
doaj   +1 more source