Results 11 to 20 of about 7,161 (183)

In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation. [PDF]

Aging Cell
Partial chemical reprogramming significantly increases mitochondrial interaction networks, affects mitochondrial morphology, speeds up mitochondrial movement dynamics, increases mitochondrial transmembrane potential, and induces TCA cycle stress. These changes in mitochondrial function contribute to lipid droplet accumulation, acute kidney injury, and ...
Mitchell W, de Magalhães CG, Tyshkovskiy A, Uchida Y, Goeminne LJE, Ichimura T, Ng EL, Moldakozhayev A, Bonventre JV, Gladyshev VN.   +9 more
europepmc   +2 more sources

A Machine-Learning Approach Identifies Rejuvenating Interventions in the Human Brain. [PDF]

Adv Sci (Weinh)
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Santamaria G, Iglesias C, Jung S, Arcos Hodar J, Nogueiras R, Del Sol A.   +5 more
europepmc   +2 more sources

Sensitization of Non-M3 Acute Myeloid Leukemia Blasts to All-Trans Retinoic Acid by the LSD1 Inhibitor Tranylcypromine: TRANSATRA Phase I Study. [PDF]

Eur J Haematol
ABSTRACT The treatment of elderly, nonfit acute myeloid leukemia (AML)/MDS patients with relapsed/refractory (R/R) disease remains challenging. As histone demethylase LSD1 (KDM1A) is a rational therapeutic target in AML, we conducted a phase I trial (“rolling‐six design”) with the LSD1 inhibitor tranylcypromine (TCP, dose levels [DL] 20, 40, 60, 80 mg ...
Kruszewski M, Schmoor C, Berg T, Rehman UU, Schittenhelm M, Götze K, Kündgen A, Pabst C, Ma T, Frey A, Stomper J, Pfeifer D, Metzger E, Jung J, Moschallski K, Thomas J, Bug G, Duyster J, Jung M, Schüle R, Wäsch R, Grishina O, Lübbert M.   +22 more
europepmc   +2 more sources

Evolution of ideas about the risk of tyramine syndrome developing during therapy with irreversible non-selective monoamine oxidase inhibitors (to the 70th anniversary of the first use of this group of antidepressants)

Неврология, нейропсихиатрия, психосоматика, 2022
We describe the history of studying of the problem of tyramine syndrome during the treatment with antidepressants, irreversible non-selective monoamine oxidase inhibitors. Data on clinical observations are presented.
D. S. Danilov, M. Yu. Brovko
doaj   +1 more source

The History of Irreversible Non-Selective MAOI Antidepressants in Russia (for their 70th Anniversary)

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2023
The history of irreversible non-selective MAOI antidepressants in the USSR and Russia is systemized. The history of representatives’ appearance is described. The history of the study of pharmacological effects is highlighted.
D. S. Danilov
doaj   +1 more source

Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
As regioisomers/bioisosteres of 1a, a 4-phenylbenzamide tranylcypromine (TCP) derivative previously disclosed by us, we report here the synthesis and biological evaluation of some (hetero)arylbenzoylamino TCP derivatives 1b-6, in which the 4-phenyl ...
Rossella Fioravanti, Veronica Rodriguez, Jonatan Caroli, Ugo Chianese, Rosaria Benedetti, Elisabetta Di Bello, Beatrice Noce, Clemens Zwergel, Davide Corinti, Dolores Viña, Lucia Altucci, Andrea Mattevi, Sergio Valente, Antonello Mai   +13 more
doaj   +1 more source

Altered states, alkaloids, and catatonia: Monoaminoxidase inhibitors and their role in the history of psychopharmacology

Frontiers in Pharmacology, 2022
Monoamine oxidases are mitochondrial enzymes that catalyze the oxidative deamination of biogenic amines (adrenaline, noradrenaline, serotonin, and dopamine), causing their inactivation and subsequently playing a fundamental role in the homeostasis of ...
Octavian Buda, Sorin Hostiuc, Ovidiu Popa-Velea, Steluta Boroghina   +3 more
doaj   +1 more source

Gene regulation and epigenotype in Friedreich's ataxia [PDF]

, 2008
Friedreich??????s ataxia (FRDA) is known to be provoked by an abnormal GAA-repeat expansion located in the first intron of the FXN gene. As a result of the GAA expansion, patients exhibit low levels of FXN mRNA, leading to FRDA.
Rothe, Nadine, Rothe, Nadine
core   +2 more sources

Discrimination Between Drug Abuse and Medical Therapy : Case report of a tranylcypromine overdose-related fatality

Sultan Qaboos University Medical Journal, 2017
Tranylcypromine is an effective antidepressant from the class of monoamine oxidase inhibitors and is structurally related to amphetamine. However, reports differ regarding the potential metabolism of tranylcypromine to amphetamine and methamphetamine ...
Maryam Akhgari, Farzaneh Jokar, Afshar Etemadi-Aleagha, Ali Ghasemi   +3 more
doaj   +1 more source

National Prescribing Trends and Cost Analysis of Antidepressants, Anxiolytics, and Hypnotics in England, 2010-2023. [PDF]

Hum Psychopharmacol
ABSTRACT Introduction We describe prescribing of anxiolytics/hypnotics/antidepressants at an all‐England level between 2010 and 2023, taking account of the influence of the COVID‐19 pandemic‐period. Methods All Primary Care Prescribing data for England for anxiolytics/hypnotics/antidepressant agents taken as tablets or capsules from 1 January 2010 to ...
Stedman M, Davies M, Levy JW, Ingram J, Taylor D, Heald A.   +5 more
europepmc   +2 more sources