Results 21 to 30 of about 4,928 (175)
Sultan Qaboos University Medical Journal, 2017 Tranylcypromine is an effective antidepressant from the class of monoamine oxidase inhibitors and is structurally related to amphetamine. However, reports differ regarding the potential metabolism of tranylcypromine to amphetamine and methamphetamine ...
Maryam Akhgari +3 more
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Frontiers in Molecular Neuroscience, 2021 ObjectivesTbx1 mutant mice are a widely used model of 22q11.2 deletion syndrome (22q11.2DS) because they manifest a broad spectrum of physical and behavioral abnormalities that is similar to that found in 22q11.2DS patients.
Ilaria Favicchia +6 more
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Increased expression and catalytic activity of prostacyclin synthase after simvastatin application to human umbilical vein endothelial cells [PDF]
Archives of Biological Sciences, 2020 In addition to lowering blood cholesterol levels, statins are known to exert antiplatelet effects. One of the key factors contributing to the antiplatelet effects of statins includes the upregulation of prostacyclin (PGI2) level.
Cho Sun-Ah, Lee Su-Jun
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Frontiers in Neurology, 2017 Recent breakthroughs in human pluripotent stem cell-derived cerebral organoids provide a valuable platform for investigating the human brain after different drugs treatments and for understanding the complex genetic background to human pathology.
Jing Huang +16 more
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Antidepressants in social anxiety disorder [PDF]
Arquivos de Neuro-Psiquiatria, 2001 Social anxiety disorder (SAD) is a marked and persistent fear of doing almost everything in front of people due to concerns about being judge by others.
Antonio E. Nardi
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Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.A bench‐stable boryl thianthrenium dication is synthesized via thianthrenation of vinyl MIDA boronate. This novel dication enables metal‐free, chemo‐, and diastereoselective late‐stage aziridination with diverse nitrogen nucleophiles. The strategic significance is further showcased by one‐pot electrochemical and asymmetric protocols and versatile ...
Veerabhadra R. Vulupala +7 more
wiley +2 more sources
Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19). Since its emergence, the COVID-19 pandemic has not only distressed medical services but also caused economic upheavals, marking urgent ...
Wei-Chung Chiou +6 more
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Hepatic Oncology, 2019 Aim: Histone-modifiable lysine-specific demethylase-1 (LSD1/KDM1A) is an oncoprotein upregulated in cancers, including hepatoma. We previously reported that the hepatoma-preventive geranylgeranoic acid (GGA) inhibits KDM1A at the same IC50 as that of the
Suemi Yabuta, Yoshihiro Shidoji
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LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials
Frontiers in Pharmacology, 2023 Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely H3K4me1/2 and H3K9me1/2, using FAD as the cofactor.
Beatrice Noce +4 more
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Acta Obstetricia et Gynecologica Scandinavica, 1997 Background. The effect of hydrogen peroxide (H2O2) on vascular tone in the human umbilical artery was investigated to determine the mechanism of vasospasm in preeclampsia. Methods.
Yuji Okatani +2 more
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