Results 41 to 50 of about 6,068 (107)

Deep Brain Stimulation in the Bed Nucleus of Stria Terminalis and Medial Forebrain Bundle in Two Patients With Treatment‐Resistant Depression and Generalized Anxiety Disorder—A Long‐Term Follow‐Up

Clinical Case Reports, Volume 13, Issue 2, February 2025.
ABSTRACT This case report presents positive outcomes from deep brain stimulation (DBS) targeting the bed nucleus of the stria terminalis (BNST) in two patients with treatment‐resistant depression and generalized anxiety disorder. DBS effects in the medial forebrain bundle (MFB) area were unclear.
Matilda Naesström, Patric Blomstedt, Viktoria Johansson   +2 more
wiley   +1 more source

Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Zahra Heydari, Roberto Gramignoli, Abbas Piryaei, Ensieh Zahmatkesh, Paria Pooyan, Homeyra Seydi, Andreas Nussler, Dagmara Szkolnicka, Hassan Rashidi, Mustapha Najimi, David C. Hay, Massoud Vosough   +11 more
wiley   +1 more source

Identification of potentially causative drugs associated with hypotension: A scoping review

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
Antihypertensives are just the tip of the iceberg of drugs that cause hypotension. This scoping review examines antihypertensive and nonantihypertensive drugs associated with hypotension, analysing 97 studies from 2013 to 2023. It examines the frequency of reporting and corresponding levels of evidence and evaluates the results taking into account ...
Nurunnisa Sari, Ulrich Jaehde, Anna Maria Wermund   +2 more
wiley   +1 more source

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors [PDF]

, 2018
Here we report corin, a synthetic hybrid agent derived from the class I HDAC inhibitor (entinostat) and an LSD1 inhibitor (tranylcypromine analog). Enzymologic analysis reveals that corin potently targets the CoREST complex and shows more sustained ...
A Laugesen, B Al-Lazikani, B Apsel, B Oronsky, BM Bolstad, C Binda, CA Lipinski, CH Arrowsmith, CM Johannessen, D Hayward, D Zingg, F Forneris, G Yan, HP Mohammad, J Bostrom, JC Culhane, JC Culhane, JE Bradner, JM Erikson, K Inui, K Luger, K Piotukh, K Yamanaka, KJ Falkenberg, L Jin, LM Szewczuk, M Yu, MA Dawson, MC Alley, MP Martin, N Portolano, P Prusevich, PH Huang, PJ Watson, PN Dyer, R Breslow, R Brown, R Li, RA Copeland, RA Copeland, RA Irizarry, RH Shoemaker, S Mimasu, SN Vasilatos, T Beckers, T Itoh, YC Duan   +46 more
core   +4 more sources

Side Effects of Psychotropic Medications Experienced by a Community Sample of People Living With Severe and Persistent Mental Illness

Health Expectations, Volume 27, Issue 6, December 2024.
ABSTRACT Background Psychotropic medications are a common treatment modality for people living with severe and persistent mental illness (SPMI). While effective in reducing relapse and hospitalisation, psychotropic medications cause numerous side effects, varying in nature and severity.
Jack C. Collins, Amanda J. Wheeler, Sara S. McMillan, Jie Hu, Sarira El‐Den, Helena Roennfeldt, Claire L. O'Reilly   +6 more
wiley   +1 more source

Synthesis of Carboxamides Tranylcypromine Analogues as LSD1 (KDM1A) Inhibitors for AML [PDF]

, 2020
Lysine-specific demethylase 1 (LSD1/KDM1A) oxidatively removes methyl groups from histone proteins and its aberrant activity has been correlated with cancers including acute myeloid leukemia (AML).
Bailey, S, Benelkebir, H, Borrello, T, Bowles, K, Crabb, S, Douglas, L, Ganesan, P, J. Duriez, P, Packham, G, Rushworth, S, Shafat, M, Tam, CH   +11 more
core  

CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of Plasmodium falciparum invasion. [PDF]

, 2017
During malaria blood-stage infections, Plasmodium parasites interact with the RBC surface to enable invasion followed by intracellular proliferation.
Barker, Robert, Chaand, Mudit, Duraisingh, Manoj T, Egan, Elizabeth, Grüring, Christof, Jones, Patrick L, Kanjee, Usheer, Lin, Kai-Min, Manzo, Jale, Weekes, Michael P, Yu, Tiffany   +10 more
core   +1 more source

A critical review of therapeutic interventions in sickle cell disease: Progress and challenges

Archiv der Pharmazie, Volume 357, Issue 11, November 2024.
Sickle cell disease reflects a complex interplay of genetics, hematology, and clinical symptoms. The intricate pathogenesis of the disease offers a landscape with various targets and treatment options. Anticipated advancements in treatment include combining fetal hemoglobin inducers with other drug classes to improve the efficacy beyond monotherapy ...
Chandu Ala, Renuka Parshuram Joshi, Pragya Gupta, Sangam Giri Goswami, Sivaprakash Ramalingam, Chandra Sekhar Kondapalli Venkata Gowri, Murugesan Sankaranarayanan   +6 more
wiley   +1 more source

Serotonergic modulation of zebrafish behavior: Towards a paradox [PDF]

, 2014
Due to the fish-specific genome duplication event (~320–350mya), some genes which code for serotonin proteins were duplicated in teleosts; this duplication event was preceded by a reorganization of the serotonergic system, with the appearance of the ...
Herculano, Anderson Manoel, Maximino, Caio   +1 more
core   +1 more source

Comparative pharmacology and abuse potential of oral dexamphetamine and lisdexamfetamine—A literature review

Human Psychopharmacology: Clinical and Experimental, Volume 39, Issue 6, November 2024.
Abstract Objective To compare the pharmacology and abuse potential of oral dexamphetamine and lisdexamfetamine (LDX). Methods A search of Medline and Embase was conducted to identify relevant articles for this literature review. Results Dexamphetamine and LDX, a prodrug of dexamphetamine, are indicated for the treatment of attention‐deficit ...
Wolfgang Kämmerer
wiley   +1 more source