Pharmacology and clinical drug candidates in redox medicine [PDF]
, 2015 SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I +11 more
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Synthesis of cyclopropyl-substituted furans by Brønsted acid promoted cascade reactions [PDF]
, 2015 Chloroacetic acid promotes an efficient and diastereoselective intramolecular cascade reaction of electron-deficient ynenones to deliver products featuring a 2,3,5-trisubstituted furan bearing a fused cyclopropyl substituent at the 5-position ...
Achmatowicz +46 more
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Inhibitory effects of agmatine on monoamine oxidase (MAO) activity: Reconciling the discrepancies [PDF]
, 2018 Agmatine has been functionally characterized as an important hormone and co-neurotransmitter in mammals. Given its ability in binding Imidazoline sites, a regolatory site of monoaminoxydase, it has been suggested to be involved in many neurological ...
Arcuri Cataldo +6 more
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THE EFFECT OF PERINATAL ALTERATION IN SEROTONIN METABOLISM ON THE DEVELOPMENT OF SOMATOSENSORY CORTEX IN RATS [PDF]
, 2015 Serotonin je biološki aktivan amin prisutan u mozgu i perifernim tkivima sisavaca. Izvršava razne funkcije ovisno o odjeljku u kojemu djeluje.
Galić, Hrvoje
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Improving Blood Brain Barrier Permeation of Small Molecules Exhibiting Chemotherapeutic and Neuroprotective Effects [PDF]
, 2008 The blood brain barrier is the body's natural defense system for limiting the brain's exposure to potentially harmful xenobiotics. This barrier exists between the blood of the systemic circulation and the brain and is made up of brain endothelial cells ...
Desino, Kelly Elizabeth
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The Association of Antidepressant Medication and Body Weight Gain [PDF]
, 2013 Objective: To review the literature and discover which antidepressants are responsible for weight gain and then to discuss the areas with lack of adequate knowledge.
Deng, Chao +2 more
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Cytochromes P450: Inhibition of CYP2A Enzymes Involved in Xenobiotic Metabolism and Generation of CYP26 Enzymes Involved in Retinoic Acid Metabolism [PDF]
, 2012 The cytochrome P450 (P450) superfamily of mixed function oxidase enzymes catalyze the metabolism of a variety of endogenous and exogenous biochemicals, including steroids, fatty acids, vitamins, eicosanoids, drugs, pesticides, and toxins.
Stephens, Eva Susanne
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Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity [PDF]
, 2016 Citation: Tsutsumi T, Iwao K, Hayashi H, et al. Potential neuroprotective effects of an LSD1 inhibitor in retinal ganglion cells via p38 MAPK activity. Invest Ophthalmol Vis Sci. 2016;57:6461-6473. DOI:10.1167/ iovs.16-19494 PURPOSE.
Hideki Hayashi +8 more
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SENSAAS (SENsitive Surface As A Shape): utilizing open-source algorithms for 3D point cloud alignment of molecules [PDF]
, 2019 Open-source 3D data processing libraries originally developed for computer vision and pattern recognition are used to align and compare molecular shapes and sub-shapes.
Douguet, Dominique, Payan, Frédéric
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Electrochemical Detection of Human Cytochrome P450 2A6 Inhibition: A Step toward Reducing Dependence on Smoking [PDF]
, 2014 Alex, Ortolani +5 more
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