Results 51 to 60 of about 7,161 (183)

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy [PDF]

, 2016
Drawing of Object No ...
Ludovica Morera, Michael Lübbert, Manfred Jung   +2 more
core   +1 more source

A Tutorial on Optimal Dynamic Treatment Regimes

Statistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT A dynamic treatment regime (DTR) is a sequence of treatment decision rules tailored to an individual's evolving status over time. In precision medicine, much focus has been placed on finding an optimal DTR which, if followed by everyone in the population, would yield the best outcome on average; and extensive investigations have been conducted
Chunyu Wang, Brian D. M. Tom
wiley   +1 more source

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors [PDF]

, 2018
Here we report corin, a synthetic hybrid agent derived from the class I HDAC inhibitor (entinostat) and an LSD1 inhibitor (tranylcypromine analog). Enzymologic analysis reveals that corin potently targets the CoREST complex and shows more sustained ...
A Laugesen, B Al-Lazikani, B Apsel, B Oronsky, BM Bolstad, C Binda, CA Lipinski, CH Arrowsmith, CM Johannessen, D Hayward, D Zingg, F Forneris, G Yan, HP Mohammad, J Bostrom, JC Culhane, JC Culhane, JE Bradner, JM Erikson, K Inui, K Luger, K Piotukh, K Yamanaka, KJ Falkenberg, L Jin, LM Szewczuk, M Yu, MA Dawson, MC Alley, MP Martin, N Portolano, P Prusevich, PH Huang, PJ Watson, PN Dyer, R Breslow, R Brown, R Li, RA Copeland, RA Copeland, RA Irizarry, RH Shoemaker, S Mimasu, SN Vasilatos, T Beckers, T Itoh, YC Duan   +46 more
core   +4 more sources

Effects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Grafts

Brazilian Journal of Cardiovascular Surgery
Objective: In this study, we aimed to examine the effects of amitriptyline, fluoxetine, tranylcypromine and venlafaxine on saphenous vein grafts in coronary artery bypass graft surgeries.
Melek Akinci, Cetin Hakan Karadag, Serhat Huseyin, Cagatay Oltulu, Suat Canbaz, Ozgur Gunduz, Ruhan Deniz Topuz   +6 more
doaj   +1 more source

Concomitant medication use and clinical outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder. [PDF]

, 2019
BackgroundRepetitive Transcranial Magnetic Stimulation (rTMS) is commonly administered to Major Depressive Disorder (MDD) patients taking psychotropic medications, yet the effects on treatment outcomes remain unknown.
Chawla, Shweta A, Cook, Ian A, Hunter, Aimee M, Krantz, David E, Leuchter, Andrew F, Levitt, Jennifer G, Minzenberg, Michael J, Rotstein, Natalie M   +7 more
core   +1 more source

Beyond the Brain: Perinatal Exposure of Rats to Serotonin Enhancers Induces Long-Term Changes in the Jejunum and Liver

Biomedicines
Serotonin (5-hydroxytryptamine, 5HT) homeostasis is essential for many physiological processes in the central nervous system and peripheral tissues.
Romana Gračan, Sofia Ana Blažević, Matea Brižić, Dubravka Hranilovic   +3 more
doaj   +1 more source

Etiology and Management of Sexual Dysfunction [PDF]

, 2009
Sexual dysfunction is the impairment or disruption of any of the three phases of normal sexual functioning, including loss of libido, impairment of physiological arousal and loss, delay or alteration of orgasm.
Bevinahalli Nanjegowda, Raveesh, Muthugaduru Shivarudrappa, Narendra Kumar, Mysore Nagaraj, Anil Kumar, Pai, Nagesh Brahmavar, Rajagopal, Rajendra, Siddika, Nayeema   +5 more
core   +2 more sources

CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of Plasmodium falciparum invasion. [PDF]

, 2017
During malaria blood-stage infections, Plasmodium parasites interact with the RBC surface to enable invasion followed by intracellular proliferation.
Barker, Robert, Chaand, Mudit, Duraisingh, Manoj T, Egan, Elizabeth, Grüring, Christof, Jones, Patrick L, Kanjee, Usheer, Lin, Kai-Min, Manzo, Jale, Weekes, Michael P, Yu, Tiffany   +10 more
core   +1 more source

Combination therapy for bipolar disorder : What to combine and which cautions to take ?

European Psychiatry, 2023
Introduction Bipolar disorder is one of the leading causes of disability among young adults. Given the heterogeneity of the disorder and the complexity of its etiopathogenesis, combination therapy is often considered as part of the treatment regimen ...
M. Gardabbou, M. Maalej, R. Feki, I. Gassara, N. Smaoui, L. Zouari, J. Ben Thabet, S. Omri, N. Charfi, M. Maalej   +9 more
doaj   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source