Results 51 to 60 of about 4,928 (175)

CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition

OncoImmunology, 2022
NK group 2, member D (NKG2D) is one of the most critical activating receptors expressed by natural killer (NK) cells. There is growing evidence that acute myeloid leukemia (AML) cells may evade NK cell-mediated cell lysis by expressing low or no ligands ...
Meng Liu, Mengbao Du, Jian Yu, Zijun Qian, Yang Gao, Wenjue Pan, Xiujie Zhao, Mowang Wang, Huimin Li, Jiaqi Zheng, Qianshuo Huang, Li-Mengmeng Wang, Haowen Xiao   +12 more
doaj   +1 more source

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay

Molecules, 2011
The extract from Mitragyna speciosa has been widely used as an opium substitute, mainly due to its morphine-like pharmacological effects. This study investigated the effects of M. speciosa alkaloid extract (MSE) on human recombinant cytochrome P450 (CYP)
Raja Elina Raja Aziddin, Zahurin Mohamed, Umarani Subramaniam, Murali Ramachandra, Zamri Chik, Wai Mun Kong   +5 more
doaj   +1 more source

LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells

Stem Cell Research & Therapy, 2020
Background Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem cells into IPCs in vitro, the ...
Fei He, Ning Li, Hai-Bo Huang, Jing-Bo Wang, Xiao-Fei Yang, Hua-Dong Wang, Wei Huang, Fu-Rong Li   +7 more
doaj   +1 more source

Defining Treatment‐Resistant Bipolar Depression: Recommendations From the ISBD Task Force

Bipolar Disorders, Volume 27, Issue 6, Page 411-423, September 2025.
ABSTRACT Objective Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment‐resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to standard therapies. However, a universally accepted definition of TRBD is lacking.
Eduard Vieta, Roger S. McIntyre, Trisha Suppes, Tamsyn E. Van Rheenen, Balwinder Singh, Kamilla Woznica Miskowiak, Allan H. Young, Lakshmi N. Yatham, Kyooseob Ha, Michael Berk, Holly A. Swartz, Chantal Henry, Maja Pantovic Stefanovic, Gerard Anmella Diaz, Aysegul Ozerdem, Wiesław J. Cubała, Diego Hidalgo‐Mazzei, Mauricio Tohen, Isabella Pacchiarotti, Paula Villela Nunes, Carlos Lopez‐Jaramillo, Ana Gonzalez‐Pinto, Paolo Brambilla, Robert Post, Jair C. Soares, Michael Bauer, Ana C. Andreazza, Xavier Justes Fradera, Montserrat Cosials‐Lopez, Giovanna Fico   +29 more
wiley   +1 more source

Hepatic monoamine oxidase B is involved in endogenous geranylgeranoic acid synthesis in mammalian liver cells[S]

Journal of Lipid Research, 2020
Geranylgeranoic acid (GGA) originally was identified in some animals and has been developed as an agent for preventing second primary hepatoma. We previously have also identified GGA as an acyclic diterpenoid in some medicinal herbs.
Yuki Tabata, Yoshihiro Shidoji
doaj   +1 more source

RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications

MedComm, Volume 6, Issue 8, August 2025.
RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang, Zonglin Li, Weilong Lin, Ruihui Xie, Hai Huang   +4 more
wiley   +1 more source

The Efficacy of Pharmacological Interventions in the Treatment of Major Depressive Disorder and Bipolar Depression With Mixed Features: A Systematic Review

Bipolar Disorders, Volume 27, Issue 5, Page 347-357, August 2025.
ABSTRACT Background There is a need to provide up‐to‐date, clinically translatable data as it relates to the treatment of a major depressive episode (MDE) with mixed features. Methods PubMed and OVID were searched from inception to July 22, 2024. Randomized controlled trials (RCTs) investigating the efficacy of pharmacological agents for adults with ...
Naomi Xiao, Liyang Yin, Serene Lee, Kayla M. Teopiz, Sabrina Wong, Gia Han Le, Sebastian Badulescu, Heidi Ka. Ying. Lo, Maj Vinberg, Bing Cao, Iria Grande, Joshua D. Rosenblat, Roger S. McIntyre   +12 more
wiley   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, Volume 15, Issue 7, Page 1041-1053, July 2025.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Forced intracellular degradation of xenoantigens as a modality for cell-based cancer immunotherapy

iScience
Summary: Given recent leverage of mesenchymal stromal cells (MSCs) as a potent vaccination platform, we investigated whether forced degradation of an expressed experimental antigen fused to small degron sequences could prime potent antitumoral responses.
Jean Pierre Bikorimana, Roudy Farah, Jamilah Abusarah, Gabrielle Arona Mandl, Mohamed Ali Erregragui, Marina Pereira Gonçalves, Sebastien Talbot, Perla Matar, Malak Lahrichi, Nehme El-Hachem, Moutih Rafei   +10 more
doaj   +1 more source