Results 61 to 70 of about 7,161 (183)

What's best when a patient doesn't respond to the maximum dose of an antidepressant? [PDF]

, 2010
Consider possible causes of the inadequate response, then weigh treatment options in light of the characteristics of the individual patient and therapy. When managing a patient with nonpsychotic depression and inadequate response to the maximum dose of a
Lo, Vincent, Maggio, Lauren
core  

Electroconvulsive therapy mediates neuroplasticity of white matter microstructure in major depression. [PDF]

, 2014
Whether plasticity of white matter (WM) microstructure relates to therapeutic response in major depressive disorder (MDD) remains uncertain. We examined diffusion tensor imaging (DTI) correlates of WM structural connectivity in patients receiving ...
Clark, K, Espinoza, RT, Joshi, SH, Leaver, AM, Lyden, H, Narr, KL, Pirnia, T, Woods, RP   +7 more
core   +1 more source

Inhibitory effects of agmatine on monoamine oxidase (MAO) activity: Reconciling the discrepancies

The EuroBiotech Journal, 2018
Agmatine has been functionally characterized as an important hormone and co-neurotransmitter in mammals. Given its ability in binding Imidazoline sites, a regolatory site of monoaminoxydase, it has been suggested to be involved in many neurological ...
Mancinelli Loretta, Ragonese Francesco, Cataldi Samuela, Ceccarini Maria Rachele, Iannitti Rossana G., Arcuri Cataldo, Fioretti Bernard   +6 more
doaj   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Assessing Condition‐Specific Adverse Event Profiles of Modafinil for Labelled and Off‐Label Uses: A Systematic Review and Meta‐Analysis

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.
ABSTRACT Modafinil is approved for excessive daytime sleepiness in narcolepsy, obstructive sleep apnoea (OSA), and shift work sleep disorder (SWSD), but its widespread off‐label use raises safety concerns. We evaluated the risk of adverse events (AEs) associated with both labelled and off‐label use of modafinil.
Jaehee Jung, Jaeyoon Youm, Jihyun Kang, Ah‐Young Kim, Jae Kyung Suh, Hye‐Young Kang   +5 more
wiley   +1 more source

Inter and intra-hemispheric structural imaging markers predict depression relapse after electroconvulsive therapy: a multisite study. [PDF]

, 2017
Relapse of depression following treatment is high. Biomarkers predictive of an individual's relapse risk could provide earlier opportunities for prevention.
Abbott, Christopher C, Espinoza, Randall T, Hellemann, Gerhard, Joshi, Shantanu H, Leaver, Amber M, Narr, Katherine L, Sui, Jing, Wade, Benjamin SC, Woods, Roger P   +8 more
core   +3 more sources

Reverse Takotsubo Cardiomyopathy Induced By Tyramine Reaction

Case Reports in Cardiology, Volume 2026, Issue 1, 2026.
Background Reverse takotsubo cardiomyopathy is a variant of takotsubo cardiomyopathy (TC) where the basal and midventricular segments of the left ventricle are akinetic. TC is typically precipitated by emotional stress; however, the exact pathogenesis of the disease remains unclear.
Robert Holley, Emma Gislingham, Danielle Harrop, Assad Movahed   +3 more
wiley   +1 more source

THE EFFECT OF PERINATAL ALTERATION IN SEROTONIN METABOLISM ON THE DEVELOPMENT OF SOMATOSENSORY CORTEX IN RATS [PDF]

, 2015
Serotonin je biološki aktivan amin prisutan u mozgu i perifernim tkivima sisavaca. Izvršava razne funkcije ovisno o odjeljku u kojemu djeluje.
Galić, Hrvoje
core   +1 more source

Suppression of Invasion and Metastasis of Triple-Negative Breast Cancer Lines by Pharmacological or Genetic Inhibition of Slug Activity

Neoplasia: An International Journal for Oncology Research, 2014
Most triple-negative breast cancers (TNBCs) exhibit gene expression patterns associated with epithelial-to-mesenchymal transition (EMT), a feature that correlates with a propensity for metastatic spread.
Giovanna Ferrari-Amorotti, Claudia Chiodoni, Fei Shen, Sara Cattelani, Angela Rachele Soliera, Gloria Manzotti, Giulia Grisendi, Massimo Dominici, Francesco Rivasi, Mario Paolo Colombo, Alessandro Fatatis, Bruno Calabretta   +11 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source