Results 61 to 70 of about 4,928 (175)

Desulfurizative Fluorination of N‐CF3 Thioformamides for the Efficient Synthesis of N(CF3)(CF2H) Amines with Enhanced Stability

Angewandte Chemie, Volume 137, Issue 26, June 24, 2025.
We present the first general synthetic strategy for accessing N(CF3)(CF2H) amines, which display a 2000‐fold increase in stability over N‐CF3 amines. The compounds are synthesized through a desulfurization–fluorination of N‐CF3 thioformamides. Abstract With poor metabolic stability being a major cause of failure in drug development, there is a pressing
Gina Wycich, Jaime Ponce‐de‐León, Linhao Liu, Franziska Schoenebeck   +3 more
wiley   +1 more source

Lysine-Specific Demethylase 1 Inhibitors: A Comprehensive Review Utilizing Computer-Aided Drug Design Technologies

Molecules
Lysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising therapeutic target for treating various cancers (such as breast cancer, liver cancer, etc.) and other diseases (blood diseases, cardiovascular diseases, etc.), owing to its observed ...
Di Han, Jiarui Lu, Baoyi Fan, Wenfeng Lu, Yiwei Xue, Meiting Wang, Taigang Liu, Shaoli Cui, Qinghe Gao, Yingchao Duan, Yongtao Xu   +10 more
doaj   +1 more source

Combined Tranylcypromine and Trifluoperazine Therapy in General Medicine [PDF]

, 1962
Ross A. Lewis
openalex   +1 more source

Dynamics of Cell Fate Decisions during Chemically Induced Multi‐Lineage Trans‐Differentiation at Single‐Cell Level

Advanced Science
Cell trans‐differentiation offers a powerful means to manipulate cell identities. By exposing cells to a combination of small molecules (SMs), cell trans‐differentiation can be induced in a simple and cost‐effective manner. However, a comprehensive atlas
Weigao E, Lijiang Fei, Jingjing Wang, Xinru Wang, Renying Wang, Xueyi Wang, Peijing Zhang, Jianhui Chen, Junqing Wu, Mengmeng Jiang, Daosheng Huang, Danmei Jia, Guoji Guo, Xiaoping Han   +13 more
doaj   +1 more source

Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective

, 2020
Xing‐Jie Dai, Ying Liu, Xiao-Peng Xiong, Lei-Peng Xue, Yi‐Chao Zheng, Hong‐Min Liu   +5 more
openalex   +1 more source

Comparative Examination of Moclobemide, Tranylcypromine, Phenelzine and Isocarboxazid for Monoamine Oxidase–A Inhibition [PDF]

, 2019
Zahra S. Alidoosti, Mahmoud Mirzaei
openalex   +1 more source

MAO inhibitors for treatment-resistant depression: Bringing an updated perspective on pioneering drugs

Pharmacological Research
In the 1950s, monoamine oxidase inhibitors transformed the pharmacological treatment of mental disorders as the first class of antidepressant drugs.
Larissa Junkes, Laiana A. Quagliato, Jose C. Appolinario, Richard I. Shader, Antonio E. Nardi   +4 more
doaj   +1 more source

Safe use of propofol in a patient receiving tranylcypromine [PDF]

, 1991
Ronald Hyde, A.J. Mortimer
openalex   +1 more source

Identification and Evaluation of Olive Phenolics in the Context of Amine Oxidase Enzyme Inhibition and Depression: In Silico Modelling and In Vitro Validation

Molecules
The Mediterranean diet well known for its beneficial health effects, including mood enhancement, is characterised by the relatively high consumption of extra virgin olive oil (EVOO), which is rich in bioactive phenolic compounds.
Tom C. Karagiannis, Katherine Ververis, Julia J. Liang, Eleni Pitsillou, Siyao Liu, Sarah M. Bresnehan, Vivian Xu, Stevano J. Wijoyo, Xiaofei Duan, Ken Ng, Andrew Hung, Erik Goebel, Assam El-Osta   +12 more
doaj   +1 more source

Tranylcypromine, a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis [PDF]

, 2016
Sun Qunyan, Ding Ding, Xishi Liu, Sun‐Wei Guo   +3 more
openalex   +1 more source